DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-6 and CG7509

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_647931.1	Gene:	CG7509 / 38579	FlyBaseID:	FBgn0035575	Length:	615	Species:	Drosophila melanogaster

Alignment Length:	569	Identity:	143/569 - (25%)
Similarity:	246/569 - (43%)	Gaps:	136/569 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 CTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVS 285
            |:|:...:|.:....|..:|.:         .|| |:|.:..:...||.::             .
  Fly    54 CSLNACESLGIVSQLLMLINSM---------PNG-TQSAANDKKPPKSKAN-------------G 95

  Fly   286 HNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNL-----SSNKIVALPTELF 345
            |||.                 .||...|:     |:|.|.|..::..     |..:.|..|....
  Fly    96 HNDG-----------------DVNGGEIN-----AMSHLANFDLVKRVRQIESRLRSVEQPVWHL 138

  Fly   346 AEQAKIIQEVYLQNNSISVLNPQLFS------NLDQLQA----------LDLSMNQITSTWIDKN 394
            |..::|  |.....:.:...||...|      ||..:..          :|||.| |.|| :.|:
  Fly   139 ATGSQI--EWNHCTSGVCRCNPDTKSFTCWNTNLKSVPVTQVIPMNMVNIDLSRN-ILST-LHKD 199

  Fly   395 TFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNK 459
            ||.||..|..|::|||.|..|..::|.||.:|.:|.:::||||:|...||..:.||:.|.||.|:
  Fly   200 TFRGLTVLKELDISHNVLDFLPFDLFQDLDSLLVLRIQNNQLEDIDHRTFWKLRNLNILDLSKNE 264

  Fly   460 LKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPL-ALRNMRHLRT 523
            :..|..........|:::::.:|.:....|:..|:...|::|:::.|::..:.. ::|.:..|:|
  Fly   265 IGMLPESIFYHAQRLTVINMCDNQIQNFPPNLLRDQLMLEELDMSRNKISELSSGSIRYLTKLKT 329

  Fly   524 VDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFE 588
            :|.|.|.|..::|..|.||.:|..|.|..|.:.:::...|.:|.||..|:|..|||:.::..||.
  Fly   330 LDFGWNQIAKIDDDFFAGLRSLRTLSLHNNRISSLSGTIFNNLANLVTLDLTTNRISHIDGNAFV 394

  Fly   589 MTSSIQAVRLDGNELNDINGLF------SNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNR 647
                         |||::|.||      |::|:.|:||:              |.|..|.|..|.
  Fly   395 -------------ELNNLNELFLGQNSMSSIPADLFLNV--------------SALTRLTLFSNN 432

  Fly   648 LSSL-SNRF-GLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLT 710
            |::| ::.| ||                         |::::|.||:|::...|...|...:.|.
  Fly   433 LTTLEADDFQGL-------------------------NNLKILLLNNNILKNFDARAFEPLSQLE 472

  Fly   711 RVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQK 759
            ::.:.:|::..|...:|..|     :.|....:..||:.|||...:|.:
  Fly   473 KLRIDSNKLMFLPHGALHGL-----KNLVAVKLDKNPWHCDCRALYLAR 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566	3/14 (21%)
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	11/56 (20%)
		leucine-rich repeat	229..249	CDD:275380	3/19 (16%)
		LRR_RI	278..468	CDD:238064	59/210 (28%)
		leucine-rich repeat	279..302	CDD:275380	3/22 (14%)
		LRR_8	301..386	CDD:290566	22/105 (21%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	4/27 (15%)
		LRR	350..729	CDD:227223	110/403 (27%)
		leucine-rich repeat	352..375	CDD:275380	6/28 (21%)
		leucine-rich repeat	376..401	CDD:275380	12/34 (35%)
		LRR_RI	<401..626	CDD:238064	70/231 (30%)
		leucine-rich repeat	402..425	CDD:275380	10/22 (45%)
		leucine-rich repeat	426..449	CDD:275380	9/22 (41%)
		leucine-rich repeat	450..473	CDD:275380	6/22 (27%)
		leucine-rich repeat	474..497	CDD:275380	4/22 (18%)
		leucine-rich repeat	498..518	CDD:275380	4/20 (20%)
		leucine-rich repeat	521..544	CDD:275380	10/22 (45%)
		leucine-rich repeat	545..566	CDD:275380	5/20 (25%)
		leucine-rich repeat	569..592	CDD:275380	8/22 (36%)
		leucine-rich repeat	593..615	CDD:275380	7/27 (26%)
		leucine-rich repeat	616..637	CDD:275380	3/20 (15%)
		leucine-rich repeat	638..662	CDD:275380	9/25 (36%)
		leucine-rich repeat	663..684	CDD:275380	0/20 (0%)
		leucine-rich repeat	685..708	CDD:275380	6/22 (27%)
		leucine-rich repeat	709..728	CDD:275380	3/18 (17%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
CG7509	NP_647931.1	LRR_8	182..241	CDD:290566	25/60 (42%)
		leucine-rich repeat	187..206	CDD:275380	12/20 (60%)
		LRR_RI	<201..386	CDD:238064	59/184 (32%)
		leucine-rich repeat	207..230	CDD:275380	10/22 (45%)
		leucine-rich repeat	231..254	CDD:275380	9/22 (41%)
		LRR_8	253..313	CDD:290566	14/59 (24%)
		leucine-rich repeat	255..278	CDD:275380	6/22 (27%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		LRR_8	303..361	CDD:290566	18/57 (32%)
		leucine-rich repeat	303..326	CDD:275380	4/22 (18%)
		leucine-rich repeat	327..350	CDD:275380	10/22 (45%)
		LRR_8	349..407	CDD:290566	21/70 (30%)
		LRR_4	350..390	CDD:289563	13/39 (33%)
		leucine-rich repeat	351..374	CDD:275380	6/22 (27%)
		leucine-rich repeat	375..398	CDD:275380	10/35 (29%)
		LRR_8	398..>443	CDD:290566	16/58 (28%)
		leucine-rich repeat	399..422	CDD:275380	8/36 (22%)
		leucine-rich repeat	423..443	CDD:275380	7/19 (37%)
		leucine-rich repeat	471..494	CDD:275380	5/27 (19%)
		LRRCT	503..554	CDD:214507	6/14 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40411
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.910