DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and lbk

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_611091.2 Gene:lbk / 36788 FlyBaseID:FBgn0034083 Length:1252 Species:Drosophila melanogaster


Alignment Length:1289 Identity:273/1289 - (21%)
Similarity:454/1289 - (35%) Gaps:367/1289 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   258 STSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALS 322
            |.|...:..:.||||:..|:....|:          .|||         ..::.|....|.|||.
  Fly   204 SASHPPAGVQGSSSSSGISIQSGSLE----------TNGF---------VADDGGQYEHAQKALE 249

  Fly   323 GL---------------KNLQILN-------LSSNKIVALPTELFAEQAKIIQEVYLQNNSISVL 365
            ..               |:.:.||       |...::..||:        .:|.::|.||.::..
  Fly   250 AAAAAAKASNKYNIDCPKDCKCLNVLFDCDKLHLERVPVLPS--------YVQTLHLANNKLNDT 306

  Fly   366 NPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILN 430
            ......||..|..:.|..|.:..  |.|  |:||..|..|.|::|.:|.:..|..:.|..|:.|:
  Fly   307 TVLEIRNLLNLTKVSLKRNLLEV--IPK--FIGLSGLKHLVLANNHITSISSESLAALPLLRTLD 367

  Fly   431 LRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNC 495
            |..|:|..|..::|...|||..|:||.|::..::.::...|..|:.|.|.||.|..:....|:|.
  Fly   368 LSRNKLHTIELNSFPKSNNLVHLILSFNEITNVNEHSFATLNNLTDLELSNNRLSTLPIRVFKNL 432

  Fly   496 SALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITM 560
            :.|:.|.||.|||:......|.:..::.:.|..|.|..::|..|..:..:..:.|..|.:.:::.
  Fly   433 NQLKKLALNFNQLEINWSTFRGLESMKNLQLKSNKIRALQDGVFYVMHKIETIDLAMNQISSLSR 497

  Fly   561 HTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSN-MPSLLWLNISDN 624
            ....:|..|:.|||:.|.|:.:|...:|.|.|::.:.|..|.:|:......: :..|..||::.|
  Fly   498 QGLFNLTKLRHLNLSFNAISRIEVDTWEFTQSLEVLDLSNNAINEFKPQHLDCLHRLKTLNLAHN 562

  Fly   625 RLE-----SFDYGHVPSTLQWLDLHKNRLS------SLSNRF-GLDSELKLQTLDVSFNQLQRIG 677
            ||:     :||   ....|:.|:|.:||||      |.:..| ||   .||:.||:..|.|::|.
  Fly   563 RLQYLQENTFD---CVKNLEELNLRRNRLSWIIEDQSAAAPFKGL---RKLRRLDLHGNNLKQIS 621

  Fly   678 PSSIP--NSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPE 740
            ..::.  |::|:|.|..|.:.::..:.|.|...|.:          |..|||.            
  Fly   622 TKAMSGLNNLEILNLGSNALASIQVNAFEHMLRLNK----------LVFKSLN------------ 664

  Fly   741 FYIGGNPFTCDCNIDWL---------QKINHITSRQYPRIMDLETIYCKLLNNRERAYI----PL 792
                   |.|||::.|.         |:..|........::|.   :.|.|::.|...:    |.
  Fly   665 -------FICDCDLVWFQQWLKNRFPQQAEHAVCGYPEHLLDR---HLKSLSSSELVCVDSPKPR 719

  Fly   793 IEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCF----------HDQTWSTNIVECSG 847
            :|.||...|.....:.          ..:|..:.||..:..          ||............
  Fly   720 VEQEPDDMLAVNAANI----------TLECIASSPTAASLAAADELKIKWRHDNQHVQERPAVHD 774

  Fly   848 AAYSEMPRRVPMDTSELYIDGNNFVELAGHSF--LGRKNLAVLYANNSNVAHIYNTTFSGLKRLL 910
            .|.:|...|..:.|::..|.|  ::.|...::  .||....        |::.:.||::...::.
  Fly   775 GASTETQIRHDLSTNQTSIYG--YLRLTNVTYESAGRYQCV--------VSNAFGTTYAQKFKIS 829

  Fly   911 I------LHLEDNHIISLEGNEFHNL------ENLRELYLQSNKIASIANGSFQML--RKLEVLR 961
            |      |.:..|  ::|:..|...|      :...|:.||     ......|...  |:|:|:|
  Fly   830 IGIHPTFLQVPSN--LTLDAGEMARLVCSASGDPTPEIALQ-----KFGGSEFPAATERRLQVIR 887

  Fly   962 LDGNRLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSC------ 1020
                          ..|.:|:                         ::.|..|:...:|      
  Fly   888 --------------EENAFLI-------------------------TNAKPSDSGIYTCTALSAA 913

  Fly  1021 --IYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGLFCYRHEL 1083
              |..|||.|:.:|......|       :|...:.|       .||............|...|..
  Fly   914 GEIKVNATLVVNDKPQPSIPL-------VHQEVVVG-------RTCVLQCLSETANADFELEHPH 964

  Fly  1084 KIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQ----ILAQTLENDIGYRLC 1144
            :.|......:    :.||...|       .|.|:        |.|.    ::.....||.|:..|
  Fly   965 REWFKENKPI----HISPTAPD-------GDRYY--------FSNNKELLVILNAQSNDAGHFRC 1010

  Fly  1145 LHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGD 1209
                             |..::::.|.|                :|.| .:||.....|.:|.|.
  Fly  1011 -----------------EITDNSRTFTL----------------QSEL-VVVKENLNWVVLLVGI 1041

  Fly  1210 LPQRDIDMDMRHYLRTSTCIEWDDKKFWQKLRLALPLPNGRGNNNKRVVS----GCLSGRTPSVN 1270
            :....|      .:....||.|...:: ||.:|.:.|...|.:...|..|    ||         
  Fly  1042 ITVTVI------CVVVDCCIIWCTLRY-QKKKLRMSLAAERHSTQLRPRSLADLGC--------- 1090

  Fly  1271 MYATSHEYQAGNGGVI-----PPPSARYADCG-SNNYATINECAAAGGGRGYKPIPTSASAAAAA 1329
                  .|...|...:     ||...|..:.| :.:|....:..|.......|...|.:.||.  
  Fly  1091 ------SYDEANHRRLTVMSTPPSEQRCLEQGLTLSYLRQTDLEAQQDHLSSKDSGTGSDAAV-- 1147

  Fly  1330 CKFNTMNQLSKKQQRDLSVAGMAKTLEHQHHHNHQANRRSQHEYA--VPSYLPSAAPAYDSVDYA 1392
                      |:...|..||    ...|:||.:.:.....:..|.  .|.|:..   .|: |:||
  Fly  1148 ----------KRTLDDFEVA----MPSHKHHTDDEEEEEVEEVYEENEPPYIKH---TYE-VNYA 1194

  Fly  1393 KQQ-----IRNNANCECVNLGTA-------------KRAAGKNPASGLPSSFSS 1428
            :.:     ..||.|.:...:|.|             |.:||   |||  |::||
  Fly  1195 EPEQHLFLQNNNHNYDGGGIGVAGGVNKMVPNALLRKCSAG---ASG--SNYSS 1243

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380 7/19 (37%)
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 50/211 (24%)
leucine-rich repeat 279..302 CDD:275380 4/22 (18%)
LRR_8 301..386 CDD:290566 20/106 (19%)
leucine-rich repeat 303..326 CDD:275380 5/37 (14%)
leucine-rich repeat 327..350 CDD:275380 5/29 (17%)
LRR 350..729 CDD:227223 111/393 (28%)
leucine-rich repeat 352..375 CDD:275380 6/22 (27%)
leucine-rich repeat 376..401 CDD:275380 8/24 (33%)
LRR_RI <401..626 CDD:238064 63/225 (28%)
leucine-rich repeat 402..425 CDD:275380 7/22 (32%)
leucine-rich repeat 426..449 CDD:275380 7/22 (32%)
leucine-rich repeat 450..473 CDD:275380 6/22 (27%)
leucine-rich repeat 474..497 CDD:275380 8/22 (36%)
leucine-rich repeat 498..518 CDD:275380 8/19 (42%)
leucine-rich repeat 521..544 CDD:275380 5/22 (23%)
leucine-rich repeat 545..566 CDD:275380 2/20 (10%)
leucine-rich repeat 569..592 CDD:275380 9/22 (41%)
leucine-rich repeat 593..615 CDD:275380 3/22 (14%)
leucine-rich repeat 616..637 CDD:275380 8/25 (32%)
leucine-rich repeat 638..662 CDD:275380 11/30 (37%)
leucine-rich repeat 663..684 CDD:275380 6/22 (27%)
leucine-rich repeat 685..708 CDD:275380 6/22 (27%)
leucine-rich repeat 709..728 CDD:275380 4/18 (22%)
LRR_8 883..943 CDD:290566 12/71 (17%)
leucine-rich repeat 885..908 CDD:275380 3/22 (14%)
leucine-rich repeat 909..932 CDD:275380 6/34 (18%)
LRR_8 932..990 CDD:290566 10/59 (17%)
leucine-rich repeat 933..956 CDD:275380 4/24 (17%)
TIR 1114..1247 CDD:214587 25/136 (18%)
lbkNP_611091.2 LRR_RI <275..446 CDD:238064 53/182 (29%)
leucine-rich repeat 293..316 CDD:275380 6/22 (27%)
LRR_8 316..373 CDD:290566 19/60 (32%)
leucine-rich repeat 317..338 CDD:275380 8/24 (33%)
leucine-rich repeat 339..362 CDD:275380 7/22 (32%)
leucine-rich repeat 363..386 CDD:275380 7/22 (32%)
LRR_8 386..445 CDD:290566 20/58 (34%)
leucine-rich repeat 387..410 CDD:275380 6/22 (27%)
leucine-rich repeat 411..434 CDD:275380 8/22 (36%)
leucine-rich repeat 435..457 CDD:275380 8/21 (38%)
LRR_8 457..516 CDD:290566 13/58 (22%)
leucine-rich repeat 458..481 CDD:275380 5/22 (23%)
leucine-rich repeat 482..505 CDD:275380 3/22 (14%)
LRR_RI <498..669 CDD:238064 54/205 (26%)
LRR_8 504..564 CDD:290566 17/59 (29%)
leucine-rich repeat 506..529 CDD:275380 9/22 (41%)
leucine-rich repeat 530..553 CDD:275380 3/22 (14%)
leucine-rich repeat 554..577 CDD:275380 8/25 (32%)
LRR_8 576..641 CDD:290566 23/67 (34%)
leucine-rich repeat 578..604 CDD:275380 9/25 (36%)
leucine-rich repeat 607..630 CDD:275380 6/22 (27%)
leucine-rich repeat 631..652 CDD:275380 5/20 (25%)
LRRCT 665..712 CDD:214507 11/49 (22%)
IG 734..823 CDD:214652 17/108 (16%)
Ig 735..823 CDD:143165 17/107 (16%)
I-set 834..924 CDD:254352 22/135 (16%)
Ig 851..924 CDD:299845 18/116 (16%)
IG 936..1027 CDD:214652 23/150 (15%)
Ig 961..1020 CDD:143165 14/94 (15%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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