DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and Tlr3

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_942086.2 Gene:Tlr3 / 364594 RGDID:735171 Length:905 Species:Rattus norvegicus


Alignment Length:1034 Identity:238/1034 - (23%)
Similarity:401/1034 - (38%) Gaps:241/1034 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   278 DLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPT 342
            ::..|:::||....||...|....:|.:|....|.||.:..:....|..|::|||..|::..:..
  Rat    53 NITVLNLTHNQLRGLPPANFTRYSQLALLDAGFNSISKLEPELCQILPLLKVLNLQHNELSQISD 117

  Fly   343 ELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNL 407
            :.||.... :.|::|.:|||..:....|.|...|..||||.|.::||.:  .|.|.|..|..|.|
  Rat   118 QTFAFCTN-LTELHLMSNSIRKIKSNPFKNQKSLIKLDLSRNGLSSTKL--GTGVQLENLQELLL 179

  Fly   408 SHNKLTKLEPEIFSDL--YTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNG 470
            :.||:..|..|....|  .:||.|:|..|.|:..:...|..:..|..|||::.:|.      || 
  Rat   180 AKNKIFALRSEELDFLGNSSLQKLDLSSNPLKEFSPGCFHAIGKLFVLLLNNAQLN------LN- 237

  Fly   471 LYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRN-------MRHLRTVDLGE 528
            |.......|.|              :::|:|:|..|||    ||..|       ..:|.::||..
  Rat   238 LTEKLCWELSN--------------TSIQNLSLANNQL----LATSNSTFSGLKQTNLTSLDLSY 284

  Fly   529 NMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSI 593
            |.:..:.:.||..|.:|..|.|..|.::::|.|:||.|.||:.|:|.|         ||    :.
  Rat   285 NSLRYVGNDAFSWLPHLKYLSLEYNNIQSLTPHSFRGLSNLRYLSLKR---------AF----TK 336

  Fly   594 QAVRLDGN-ELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRF-G 656
            |:|.|..: .::|.:  |..:..|..||:.||.:....                     ||.| |
  Rat   337 QSVALASHPNIDDFS--FQWLKCLEHLNMDDNTIPGIK---------------------SNTFTG 378

  Fly   657 LDSELKLQTLDVSFNQLQRIGPS---SIPNSIELLFLN--DNLITTVDPDTFMHKTNLTRVDLYA 716
            |.| ||..:|..:|..||.:...   |:.:| .||.||  .|.|:.:...||.....|..:||..
  Rat   379 LVS-LKYLSLSKTFTGLQTLTNETFVSLTHS-PLLTLNLTKNHISKIASGTFSWLGQLRILDLGL 441

  Fly   717 NQITTLDIKSLRILPVWEHRALP---EFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETIY 778
            |:|.       :.|...|.|.|.   |.|:..|.:        ||    :||:.:..:..|:.:.
  Rat   442 NEIE-------QELTGQEWRGLGNIFEIYLSYNKY--------LQ----LTSKSFTLVPSLQRLM 487

  Fly   779 CKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIV 843
            .:      |..:..::..|..|...|                        |.|.           
  Rat   488 LR------RVALKSVDISPSPFRPLY------------------------NLTI----------- 511

  Fly   844 ECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYN-------- 900
                                |.:..||...|......|.:||.:|...::|:|.::.        
  Rat   512 --------------------LDLSNNNIANLNEDLLEGLENLEILDFQHNNLARLWKHANPGGPV 556

  Fly   901 TTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGN 965
            ....||..|.||:||.|.:..:....|.||..|:.:.|..|.:.::....|.....|..|.|..|
  Rat   557 NFLKGLSHLHILNLESNGLDEIPVKVFKNLFELKSINLGLNNLNTLLPSIFDDQTSLRSLNLQKN 621

  Fly   966 RLMHFEVWQLS-ANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVL 1029
            .:...|..... |...|..:.::.|.:.|.|..:|.|..:|.|:...|.:.|             
  Rat   622 LITSVEKSVFGPAFHNLNSLDMSFNPFDCTCESIAWFVTWLNQTHTNIPELS------------- 673

  Fly  1030 REKNGTKCTLRDGVAHYM-HTNEIEGLLPLLL--VATCAFVAFFGLIF-------------GLFC 1078
                          .||: :|.:....||:.|  .::|...|.|.|:|             .|..
  Rat   674 --------------THYLCNTPQRYHGLPVKLFDTSSCKDSAPFQLLFIINTSTLLTFILAVLLI 724

  Fly  1079 YRHELKI---WAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLENDIG 1140
            :....:|   |..|.:.::.|     :.:|...::....||..::.:|..:|.:..:...|.|..
  Rat   725 HFEGWRISFYWNVSVHRILGF-----KEIDAQGEQFEYTAYIIHAQKDRDWVWEHFSPMEEQDQS 784

  Fly  1141 YRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNE-WSRFEYKSALHELVKRR-KRVV 1203
            .:.||..||........:|::.:.:.:::.:.|::.:.|.:. ..||:...|:.:.:::. ..::
  Rat   785 LKFCLEERDFEAGVLGLEAIVNSIKRSRKIIFVITHHLLKDPLCRRFKVHHAVQQAIEQNLDSII 849

  Fly  1204 FILYGDLPQRDID--MDMRHYLRTSTCI-EWDDKK-----FWQKLRLALPLPNGRGNNN 1254
            .|...::|...::  :.:|..:..|.|| .|..:|     |..||::||      |:.|
  Rat   850 LIFLQNIPDYKLNHALCLRRGMFKSHCILNWPIQKERINAFHHKLQVAL------GSRN 902

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380 238/1034 (23%)
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 57/191 (30%)
leucine-rich repeat 279..302 CDD:275380 6/22 (27%)
LRR_8 301..386 CDD:290566 26/84 (31%)
leucine-rich repeat 303..326 CDD:275380 6/22 (27%)
leucine-rich repeat 327..350 CDD:275380 7/22 (32%)
LRR 350..729 CDD:227223 112/394 (28%)
leucine-rich repeat 352..375 CDD:275380 7/22 (32%)
leucine-rich repeat 376..401 CDD:275380 11/24 (46%)
LRR_RI <401..626 CDD:238064 67/234 (29%)
leucine-rich repeat 402..425 CDD:275380 8/24 (33%)
leucine-rich repeat 426..449 CDD:275380 7/22 (32%)
leucine-rich repeat 450..473 CDD:275380 8/22 (36%)
leucine-rich repeat 474..497 CDD:275380 2/22 (9%)
leucine-rich repeat 498..518 CDD:275380 9/26 (35%)
leucine-rich repeat 521..544 CDD:275380 7/22 (32%)
leucine-rich repeat 545..566 CDD:275380 8/20 (40%)
leucine-rich repeat 569..592 CDD:275380 6/22 (27%)
leucine-rich repeat 593..615 CDD:275380 5/22 (23%)
leucine-rich repeat 616..637 CDD:275380 5/20 (25%)
leucine-rich repeat 638..662 CDD:275380 6/24 (25%)
leucine-rich repeat 663..684 CDD:275380 5/23 (22%)
leucine-rich repeat 685..708 CDD:275380 8/24 (33%)
leucine-rich repeat 709..728 CDD:275380 5/18 (28%)
LRR_8 883..943 CDD:290566 19/67 (28%)
leucine-rich repeat 885..908 CDD:275380 6/30 (20%)
leucine-rich repeat 909..932 CDD:275380 9/22 (41%)
LRR_8 932..990 CDD:290566 11/58 (19%)
leucine-rich repeat 933..956 CDD:275380 4/22 (18%)
TIR 1114..1247 CDD:214587 29/142 (20%)
Tlr3NP_942086.2 leucine-rich repeat 37..53 CDD:275380 238/1034 (23%)
leucine-rich repeat 54..77 CDD:275380 6/22 (27%)
PLN00113 66..>646 CDD:215061 178/725 (25%)
leucine-rich repeat 78..101 CDD:275380 6/22 (27%)
leucine-rich repeat 102..125 CDD:275380 7/22 (32%)
leucine-rich repeat 126..149 CDD:275380 7/22 (32%)
leucine-rich repeat 150..199 CDD:275380 19/50 (38%)
leucine-rich repeat 200..250 CDD:275380 17/70 (24%)
leucine-rich repeat 251..276 CDD:275380 9/28 (32%)
leucine-rich repeat 277..300 CDD:275380 7/22 (32%)
leucine-rich repeat 301..322 CDD:275380 8/20 (40%)
leucine-rich repeat 325..381 CDD:275380 21/91 (23%)
leucine-rich repeat 382..407 CDD:275380 7/24 (29%)
leucine-rich repeat 410..433 CDD:275380 8/22 (36%)
leucine-rich repeat 434..458 CDD:275380 9/30 (30%)
leucine-rich repeat 459..482 CDD:275380 7/34 (21%)
leucine-rich repeat 483..508 CDD:275380 5/54 (9%)
leucine-rich repeat 509..532 CDD:275380 6/53 (11%)
leucine-rich repeat 533..564 CDD:275380 6/30 (20%)
leucine-rich repeat 565..586 CDD:275380 7/20 (35%)
leucine-rich repeat 589..612 CDD:275380 4/22 (18%)
leucine-rich repeat 613..631 CDD:275380 5/17 (29%)
LRRCT 646..698 CDD:214507 15/78 (19%)
Tlr3_TMD 699..731 CDD:407816 5/31 (16%)
TIR 756..901 CDD:214587 30/150 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.780

Return to query results.
Submit another query.