DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and Lgi4

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_955793.1 Gene:Lgi4 / 361549 RGDID:735035 Length:537 Species:Rattus norvegicus


Alignment Length:489 Identity:110/489 - (22%)
Similarity:178/489 - (36%) Gaps:122/489 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   826 CPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYA 890
            ||..|:|..:.|.      |.|:  .|:|.........|.:.......|...|||...:|.:|..
  Rat    27 CPPRCSCSKESTL------CEGS--PELPESFSTTLLSLSLVRMGVSRLKAGSFLKMPSLHLLLF 83

  Fly   891 NNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLR 955
            .::..:.|....|.||..|..|.:|||.|.|:..|....|.:|..|.|.:|.:.::....||.|.
  Rat    84 TSNTFSVIEGDAFIGLSYLQYLFIEDNKIGSISKNALRGLRSLTHLSLANNHLEALPRFLFQGLE 148

  Fly   956 KLEVLRLDGNRLMHFE-----VWQLSANPYLVEISLADNQWSCE-CGYLARFR-NYLGQSSEKII 1013
            .|..:.|.||   .|:     :|.|...| :|..|:...  :|. ...||:.: |:|.....| .
  Rat   149 TLTHVDLRGN---PFQCDCRVLWLLQWMP-MVNASVGTG--ACAGPSALAQIQLNHLDPKKFK-C 206

  Fly  1014 DASRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLPLLL-------------VATCA 1065
            .|:.:|.:.....|.|..::.:    ..|..|.:......|...:|:             ::..:
  Rat   207 KATELSWLQTVGESALSVESFS----YQGEPHMVLAQPFAGRCLILVWDYSLQRFRSEEELSAPS 267

  Fly  1066 FVAFFGLIFG--LFCYRHEL----KIWAHSTNCLMNFCYKSPRF----VDQLDKE---RPNDAYF 1117
            .|:...|:.|  ||.....|    ::|:.|          ||..    |..|..:   |||||..
  Rat   268 VVSCKPLVLGPRLFILAARLWGGSQLWSRS----------SPDLRLTPVQVLAPQRLLRPNDAEL 322

  Fly  1118 AYSLQDEHFV----NQILAQTL--ENDIGY--RLCLH--YRDVNINAYITDA---LIEAAESAKQ 1169
            .:......||    ::..:.||  .:..|:  |..||  :||.:..|...|.   |:.|:.|.:.
  Rat   323 LWLDGQPCFVVADASKAGSTTLLCRDGPGFYPRQSLHAWHRDTDAEALELDGRPHLLLASASQRP 387

  Fly  1170 FVLVLSKNFLYNEW--SRFEYKSALHELVKRRKRVVFILYGDLPQR-------------DIDMDM 1219
            .:.         .|  .|||.::                  |:|:.             |:.:.:
  Rat   388 VLF---------HWFGGRFERRT------------------DIPEAEDVYATKHFQAGGDVFLCL 425

  Fly  1220 RHYLRTSTCIEWDDKKFWQKLRLALPLPNGRGNN 1253
            ..|:..|..:.||...|    ||...||: ||::
  Rat   426 TRYIGDSMVMRWDGSMF----RLLQQLPS-RGSH 454

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064
leucine-rich repeat 279..302 CDD:275380
LRR_8 301..386 CDD:290566
leucine-rich repeat 303..326 CDD:275380
leucine-rich repeat 327..350 CDD:275380
LRR 350..729 CDD:227223
leucine-rich repeat 352..375 CDD:275380
leucine-rich repeat 376..401 CDD:275380
LRR_RI <401..626 CDD:238064
leucine-rich repeat 402..425 CDD:275380
leucine-rich repeat 426..449 CDD:275380
leucine-rich repeat 450..473 CDD:275380
leucine-rich repeat 474..497 CDD:275380
leucine-rich repeat 498..518 CDD:275380
leucine-rich repeat 521..544 CDD:275380
leucine-rich repeat 545..566 CDD:275380
leucine-rich repeat 569..592 CDD:275380
leucine-rich repeat 593..615 CDD:275380
leucine-rich repeat 616..637 CDD:275380
leucine-rich repeat 638..662 CDD:275380
leucine-rich repeat 663..684 CDD:275380
leucine-rich repeat 685..708 CDD:275380
leucine-rich repeat 709..728 CDD:275380
LRR_8 883..943 CDD:290566 19/59 (32%)
leucine-rich repeat 885..908 CDD:275380 6/22 (27%)
leucine-rich repeat 909..932 CDD:275380 9/22 (41%)
LRR_8 932..990 CDD:290566 17/62 (27%)
leucine-rich repeat 933..956 CDD:275380 7/22 (32%)
TIR 1114..1247 CDD:214587 31/160 (19%)
Lgi4NP_955793.1 leucine-rich repeat 54..77 CDD:275378 5/22 (23%)
LRR_8 76..136 CDD:290566 19/59 (32%)
leucine-rich repeat 78..101 CDD:275378 6/22 (27%)
LRR_4 102..140 CDD:289563 13/37 (35%)
leucine-rich repeat 102..125 CDD:275378 9/22 (41%)
leucine-rich repeat 126..149 CDD:275378 7/22 (32%)
leucine-rich repeat 150..162 CDD:275378 5/14 (36%)
LRRCT 158..207 CDD:214507 13/55 (24%)
EPTP <220..251 CDD:281697 6/34 (18%)
EPTP 351..392 CDD:281697 11/49 (22%)
EPTP 396..438 CDD:281697 8/59 (14%)
EPTP 441..482 CDD:281697 7/19 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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