DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-6 and CG14762

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001246198.1	Gene:	CG14762 / 35768	FlyBaseID:	FBgn0033250	Length:	498	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	140/570 - (24%)
Similarity:	224/570 - (39%)	Gaps:	177/570 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   253 NGSTESTSTTESA--KKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLR-RLRVLSVNNNGIS 314
            ||......||:.|  .||..:....|..:.||.:.||:...|  .||..|. .:|.|:::|:.::
  Fly    55 NGLDILCETTDLAHITKSMGTLKGKSPIIFYLKLRHNNLPKL--QGFVFLALDIRHLTIHNSSLA 117

  Fly   315 MIADKALSGL-KNLQILNLSSNKIVALPTELFAEQAKIIQEVY------LQNNSISVLNPQLFSN 372
            .|.:.|||.| ..|..|::|.|::..:|::       .:|.::      |.:|.|:|::...|..
  Fly   118 AIEENALSSLGAGLTQLDVSLNQMKTVPSQ-------ALQHLFHLLILNLNHNKITVIHNNAFEG 175

  Fly   373 LDQLQALDLSMNQITSTWIDKNTFVGL-IRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQL 436
            |:.|:.|.|..|:||.  ||...|.|| ..:..|||..|.||.:..:..|.|.||:.|.::.|::
  Fly   176 LETLEILTLYENKITQ--IDPEAFRGLEDHIKRLNLGGNDLTNIPQKALSILSTLKKLEIQENKI 238

  Fly   437 ENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSA-LQD 500
            ..|:...|..:.:|.:|:|:||.:..:.|...:.|.:|:.|.|:.|.:..:..|||:.... ||.
  Fly   239 RTISEGDFEGLQSLDSLILAHNMITTVPANVFSHLTLLNSLELEGNKISVIDKDAFKGLEENLQY 303

  Fly   501 LNLNGNQLKTVPL-ALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFR 564
            |.|..||:.|:|. |||.:..||.:||..|.|.|:.:.||.|.|:
  Fly   304 LRLGDNQIHTIPSEALRPLHRLRHLDLRNNNINVLAEDAFTGFGD-------------------- 348

  Fly   565 DLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESF 629
               :|..|||.:|.|.|                               :||||:.|::
  Fly   349 ---SLTFLNLQKNDIKV-------------------------------LPSLLFENLN------- 372

  Fly   630 DYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNL 694
                                            .|:||::..|:|||| |..|...:
  Fly   373 --------------------------------SLETLNLQNNKLQRI-PQDIMEPV--------- 395

  Fly   695 ITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQK 759
                                         |.:|||:.:.:           ||..|.|.:.|..|
  Fly   396 -----------------------------IDTLRIIDITD-----------NPLNCSCELTWFPK 420

  Fly   760 INHITSRQYPRIMDLETIYCKL-LNNRERAYIPLIEAEPKHFLCTYKTHC 808
            :......:...:...:...|.: |:|||.    .::|.|     |.|.||
  Fly   421 LLEDLKNKDDEMSQKKKPLCHMSLDNREY----FVQAMP-----TEKMHC 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	8/26 (31%)
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	59/198 (30%)
		leucine-rich repeat	279..302	CDD:275380	8/23 (35%)
		LRR_8	301..386	CDD:290566	24/92 (26%)
		leucine-rich repeat	303..326	CDD:275380	8/23 (35%)
		leucine-rich repeat	327..350	CDD:275380	5/22 (23%)
		LRR	350..729	CDD:227223	92/387 (24%)
		leucine-rich repeat	352..375	CDD:275380	7/28 (25%)
		leucine-rich repeat	376..401	CDD:275380	11/25 (44%)
		LRR_RI	<401..626	CDD:238064	62/226 (27%)
		leucine-rich repeat	402..425	CDD:275380	8/22 (36%)
		leucine-rich repeat	426..449	CDD:275380	5/22 (23%)
		leucine-rich repeat	450..473	CDD:275380	7/22 (32%)
		leucine-rich repeat	474..497	CDD:275380	7/22 (32%)
		leucine-rich repeat	498..518	CDD:275380	11/20 (55%)
		leucine-rich repeat	521..544	CDD:275380	10/22 (45%)
		leucine-rich repeat	545..566	CDD:275380	0/20 (0%)
		leucine-rich repeat	569..592	CDD:275380	7/22 (32%)
		leucine-rich repeat	593..615	CDD:275380	0/21 (0%)
		leucine-rich repeat	616..637	CDD:275380	3/20 (15%)
		leucine-rich repeat	638..662	CDD:275380	0/23 (0%)
		leucine-rich repeat	663..684	CDD:275380	10/20 (50%)
		leucine-rich repeat	685..708	CDD:275380	0/22 (0%)
		leucine-rich repeat	709..728	CDD:275380	1/18 (6%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
CG14762	NP_001246198.1	leucine-rich repeat	85..105	CDD:275380	8/21 (38%)
		LRR_RI	93..384	CDD:238064	101/394 (26%)
		leucine-rich repeat	107..129	CDD:275380	8/21 (38%)
		leucine-rich repeat	131..154	CDD:275380	6/29 (21%)
		LRR_8	154..214	CDD:290566	21/61 (34%)
		leucine-rich repeat	155..178	CDD:275380	6/22 (27%)
		leucine-rich repeat	179..203	CDD:275380	11/25 (44%)
		leucine-rich repeat	204..227	CDD:275380	8/22 (36%)
		LRR_8	226..286	CDD:290566	17/59 (29%)
		leucine-rich repeat	228..251	CDD:275380	5/22 (23%)
		leucine-rich repeat	252..275	CDD:275380	7/22 (32%)
		LRR_8	276..335	CDD:290566	23/58 (40%)
		leucine-rich repeat	276..300	CDD:275380	7/23 (30%)
		leucine-rich repeat	301..324	CDD:275380	11/22 (50%)
		leucine-rich repeat	325..349	CDD:275380	11/46 (24%)
		LRR_8	349..409	CDD:290566	27/179 (15%)
		leucine-rich repeat	350..373	CDD:275380	12/92 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910