Protein Alignment Toll-6 and IL1R1

DIOPT Version :10

• Sequence 1: NP_524081.1
• Gene: Toll-6 / 39663
• FlyBaseID: FBgn0036494
• Length: 1514
• Species: Drosophila melanogaster
• Sequence 2: NP_000868.1
• Gene: IL1R1 / 3554
• HGNCID: 5993
• Length: 569
• Species: Homo sapiens
• Alignment Length: 418
• Identity: 81/418 - (19%)
• Similarity: 163/418 - (38%)
• Gaps: 93/418 - (22%)

  Fly   900 NTTFSGLK-RLLILHLEDNH--------IISLEGNEFHNLENLRELYLQSNK-----IASIANGS 950
            |..|||:| ||:::::.:.|        ..:..|.::.....:..:.|:.||     |.|.||
Human   171 NIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEENKPTRPVIVSPAN-- 233

  Fly   951 FQMLRKLEVLRLD-GNRLMHFEVWQLSANPYLVEISLAD-NQWSCECGYLARFRNYLGQ---SSE 1010
                   |.:.:| |:::      ||..|   |...|:| ..|......:......||:   |.|
Human   234 -------ETMEVDLGSQI------QLICN---VTGQLSDIAYWKWNGSVIDEDDPVLGEDYYSVE 282

  Fly  1011 KIIDASRVSCIYNNATSVLRE---KNGTKCTLRDGVAHYMHTNEIEGLLPLL-----LVATCAFV 1067
            ...:..|.:.|.....|.:..   |:...|..::  .|.:....|:.:.|:.     ::..|..:
Human   283 NPANKRRSTLITVLNISEIESRFYKHPFTCFAKN--THGIDAAYIQLIYPVTNFQKHMIGICVTL 345

  Fly  1068 AFFGLIFGLFCY---RHELKIWAHSTNCLMNFCYKSPRFVD-QLDKERPNDAYFAY-------SL 1121
            ... ::..:|.|   :.::.:|...:      ||.   |:. :....:..|||..|       |.
Human   346 TVI-IVCSVFIYKIFKIDIVLWYRDS------CYD---FLPIKASDGKTYDAYILYPKTVGEGST 400

  Fly  1122 QD-EHFVNQILAQTLENDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEW-- 1183
            .| :.||.::|.:.||...||:|.::.||..:...|.:.:.|..:.:::.:::|.:......|
Human   401 SDCDIFVFKVLPEVLEKQCGYKLFIYGRDDYVGEDIVEVINENVKKSRRLIIILVRETSGFSWLG 465

  Fly  1184 -SRFEYKSALHELVKRRKRVVFIL------YGDLPQRDIDMDMRHYLRTSTCIEWD--------- 1232
             |..|..:..:.||:...:||.:.      |..:|:....:..:|     ..|.|.
Human   466 GSSEEQIAMYNALVQDGIKVVLLELEKIQDYEKMPESIKFIKQKH-----GAIRWSGDFTQGPQS 525

  Fly  1233 -DKKFWQKLRLALPLPNGRGNNNKRVVS 1259
             ..:||:.:|..:|:.....::..:::|
Human   526 AKTRFWKNVRYHMPVQRRSPSSKHQLLS 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_524081.1	PPP1R42	<135..>242	CDD:455733
		leucine-rich repeat	148..171	CDD:275380
		leucine-rich repeat	172..201	CDD:275380
		LRR_8	200..>246	CDD:404697
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		leucine-rich repeat	279..302	CDD:275380
		LRR	299..654	CDD:443914
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	426..449	CDD:275380
		leucine-rich repeat	450..473	CDD:275380
		leucine-rich repeat	474..497	CDD:275380
		leucine-rich repeat	498..518	CDD:275380
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..566	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		leucine-rich repeat	593..615	CDD:275380
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		LRR_8	662..719	CDD:404697
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR	<863..>990	CDD:443914	25/105 (24%)
		leucine-rich repeat	885..908	CDD:275380	5/8 (63%)
		leucine-rich repeat	909..932	CDD:275380	3/30 (10%)
		leucine-rich repeat	933..956	CDD:275380	7/27 (26%)
		TIR	1114..1247	CDD:214587	35/159 (22%)
IL1R1	NP_000868.1	Ig1_IL1R_like	24..114	CDD:409583
		Ig strand A	25..28	CDD:409583
		Ig strand A'	31..35	CDD:409583
		Ig strand B	39..44	CDD:409583
		Ig strand C	54..58	CDD:409583
		Ig strand C'	63..65	CDD:409583
		Ig strand D	73..77	CDD:409583
		Ig strand E	79..83	CDD:409583
		Ig strand F	92..100	CDD:409583
		Ig strand G	103..114	CDD:409583
		Ig2_IL1R_like	126..219	CDD:409586	9/47 (19%)
		Ig strand A	128..133	CDD:409586
		Ig strand B	138..142	CDD:409586
		Ig strand C	157..162	CDD:409586
		Ig strand C'	165..167	CDD:409586
		Ig strand D	173..177	CDD:409586	2/3 (67%)
		Ig strand E	179..184	CDD:409586	2/4 (50%)
		Ig strand F	193..202	CDD:409586	0/8 (0%)
		Ig strand G	205..218	CDD:409586	0/12 (0%)
		Ig3_IL1R_like	226..329	CDD:409526	25/122 (20%)
		Ig strand A	226..229	CDD:409526	0/2 (0%)
		Ig strand A'	234..237	CDD:409526	1/2 (50%)
		Ig strand B	242..251	CDD:409526	3/17 (18%)
		Ig strand C	256..262	CDD:409526	2/5 (40%)
		Ig strand C'	264..267	CDD:409526	0/2 (0%)
		Ig strand D	273..282	CDD:409526	3/8 (38%)
		Ig strand E	290..298	CDD:409526	1/7 (14%)
		Ig strand F	309..316	CDD:409526	1/6 (17%)
		Ig strand G	319..329	CDD:409526	1/9 (11%)
		TIR	384..540	CDD:214587	34/160 (21%)