DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and rdo

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001286024.1	Gene:	rdo / 35077	FlyBaseID:	FBgn0243486	Length:	757	Species:	Drosophila melanogaster

Alignment Length:	762	Identity:	169/762 - (22%)
Similarity:	273/762 - (35%)	Gaps:	253/762 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   221 CTLSELSALNMSENRLQ-DVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDV 284
            ||...|::| :|.|.|. ||..:..|.    |.|..|...:..:..|            ||.|.:
  Fly    42 CTKGGLNSL-LSPNELDVDVKVIIIRG----PRNSITIGPALRQFMK------------LEILRI 89

  Fly   285 SHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQA 349
            :.::...:.|..|..|:.||:|.::.|.|:.|.:....|..||..|:||.||::.:.:
  Fly    90 TDSNLPAIGAESFWGLKYLRILDLSKNNITNITENNFRGQDNLLELDLSKNKVLRMAS------- 147

  Fly   350 KIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTK 414
                              ..|.:|..|:.|:|:.|.|... :.:|.|: |.||..|:||.|.|..
  Fly   148 ------------------STFRHLTDLRRLNLADNSIVEL-VQRNFFM-LSRLKYLDLSGNPLQD 192

  Fly   415 LEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSL 479
            |:|::|.|:..|::|..|:.||:.|....:..:..|..|.|..|:.|:||
  Fly   193 LQPDVFRDVPELKVLKCRNCQLKKINPQMYNLLPLLSELDLGRNEFKFLD--------------- 242

  Fly   480 DNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGN 544
                     .|.||:...|..:.|:||||                       :|:.|..|:...:
  Fly   243 ---------KDEFRDVKRLTKVLLDGNQL-----------------------SVVVDQLFRMQKS 275

  Fly   545 LYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGL 609
            |..|.|..|.|..:...:|..|.||..|:|:.|::..:||.:....|::..:.:.||.|.|:..:
  Fly   276 LNHLDLSYNRLAKVPNDSFLQLTNLTFLDLSYNKLVRLEPQSIRSLSNLLTLNISGNVLMDLREM 340

  Fly   610 -------------------FSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRF 655
                               |..:|.|..|.|:       |.|.:|..|    ||..:
  Fly   341 RETFEPLIYYFFLTCSKLFFQLIPQLTHLAIA-------DMGTMPVGL----LHPFK-------- 386

  Fly   656 GLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYA-NQI 719
                  :|:.|::|.|.                 ||:..:..:||...:...:|:|..|:. ::.
  Fly   387 ------QLRYLNISGNS-----------------LNNTALEVIDPCRELEFLDLSRNQLHGISED 428

  Fly   720 TTLDIKSLRILPVWEHRALPEFYIGGNPFTCD-CNIDWLQKINHITSRQ-----YPRIMDLETIY 778
            |.|.|:.:|           ...:..||..|| |::..|  ||.:...|     ||        .
  Fly   429 TVLRIQGIR-----------NVRLDNNPLICDECHMGKL--INVVRQLQWKWDTYP--------I 472

  Fly   779 CKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIV 843
            |.|..:...|.|..::....|...|:.|              |.|....:.         |.|.:
  Fly   473 CFLPKSLRGAEINNLDINGLHTCLTFIT--------------DEEQNAAST---------SYNFL 514

  Fly   844 ECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYAN-----NSNVAHIYNTTF 903
            |..|.                    |....|.|..|:   .:||:..:     :.|.|..|.
  Fly   515 EHGGL--------------------NTLAILGGIIFV---LIAVIILSLVACFSKNRARYYT--- 553

  Fly   904 SGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGS 950
                       .::|   |.|:|...||.    .|::..|.::.|||
  Fly   554 -----------REDH---LNGSESKCLEK----NLEATTITTLGNGS 582

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566	6/14 (43%)
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	14/57 (25%)
		leucine-rich repeat	229..249	CDD:275380	7/20 (35%)
		LRR_RI	278..468	CDD:238064	54/189 (29%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR_8	301..386	CDD:290566	20/84 (24%)
		leucine-rich repeat	303..326	CDD:275380	7/22 (32%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		LRR	350..729	CDD:227223	90/398 (23%)
		leucine-rich repeat	352..375	CDD:275380	2/22 (9%)
		leucine-rich repeat	376..401	CDD:275380	8/24 (33%)
		LRR_RI	<401..626	CDD:238064	60/243 (25%)
		leucine-rich repeat	402..425	CDD:275380	10/22 (45%)
		leucine-rich repeat	426..449	CDD:275380	6/22 (27%)
		leucine-rich repeat	450..473	CDD:275380	7/22 (32%)
		leucine-rich repeat	474..497	CDD:275380	3/22 (14%)
		leucine-rich repeat	498..518	CDD:275380	6/19 (32%)
		leucine-rich repeat	521..544	CDD:275380	3/22 (14%)
		leucine-rich repeat	545..566	CDD:275380	6/20 (30%)
		leucine-rich repeat	569..592	CDD:275380	6/22 (27%)
		leucine-rich repeat	593..615	CDD:275380	5/40 (13%)
		leucine-rich repeat	616..637	CDD:275380	6/20 (30%)
		leucine-rich repeat	638..662	CDD:275380	3/23 (13%)
		leucine-rich repeat	663..684	CDD:275380	4/20 (20%)
		leucine-rich repeat	685..708	CDD:275380	4/22 (18%)
		leucine-rich repeat	709..728	CDD:275380	6/19 (32%)
		LRR_8	883..943	CDD:290566	12/64 (19%)
		leucine-rich repeat	885..908	CDD:275380	5/27 (19%)
		leucine-rich repeat	909..932	CDD:275380	5/22 (23%)
		LRR_8	932..990	CDD:290566	5/19 (26%)
		leucine-rich repeat	933..956	CDD:275380	5/18 (28%)
		TIR	1114..1247	CDD:214587
rdo	NP_001286024.1	leucine-rich repeat	84..107	CDD:275380	6/22 (27%)
		leucine-rich repeat	108..131	CDD:275380	7/22 (32%)
		LRR_8	131..190	CDD:290566	23/85 (27%)
		leucine-rich repeat	132..155	CDD:275380	8/47 (17%)
		LRR_RI	151..422	CDD:238064	85/361 (24%)
		leucine-rich repeat	156..179	CDD:275380	8/24 (33%)
		LRR_8	178..262	CDD:290566	31/107 (29%)
		leucine-rich repeat	180..203	CDD:275380	10/22 (45%)
		leucine-rich repeat	204..251	CDD:275380	16/70 (23%)
		leucine-rich repeat	252..275	CDD:275380	9/45 (20%)
		LRR_8	274..334	CDD:290566	17/59 (29%)
		leucine-rich repeat	276..299	CDD:275380	7/22 (32%)
		LRR_4	298..342	CDD:289563	12/43 (28%)
		leucine-rich repeat	300..323	CDD:275380	6/22 (27%)
		leucine-rich repeat	388..411	CDD:275380	8/39 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453829
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740