DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-6 and LRRTM1

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_849161.2	Gene:	LRRTM1 / 347730	HGNCID:	19408	Length:	522	Species:	Homo sapiens

Alignment Length:	282	Identity:	83/282 - (29%)
Similarity:	132/282 - (46%)	Gaps:	33/282 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   372 NLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQL 436
            ||..|..|.|..|.::.  :....|.||::|..|.|.||.:..::.:.|..|..::.|.|..||:
Human    63 NLSGLLGLSLRYNSLSE--LRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQI 125

  Fly   437 ENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDL 501
            ..:...||.||.||.::.||:|||:.|.....:||..|:.|.:..||:..|....|::|.:|:.|
Human   126 TQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFL 190

  Fly   502 NLNGNQLKTV-------------------PLALRNMRH------LRTVDLGENMITVMEDSAFKG 541
            ::..||||::                   .|...|..|      |.::.|..|.:.::. |:...
Human   191 DIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKVAIVV-SSLDW 254

  Fly   542 LGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDI 606
            :.||..:.|.||.:|.:..|.|..:|:||.|.|..||:..:||.......|:.::.|.|| |.|.
Human   255 VWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN-LWDC 318

  Fly   607 NGLFSNMPSLL-WLNISDNRLE 627
            .   .|:.:|. |||....|.:
Human   319 G---RNVCALASWLNNFQGRYD 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	32/95 (34%)
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566	6/13 (46%)
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR	350..729	CDD:227223	83/282 (29%)
		leucine-rich repeat	352..375	CDD:275380	2/2 (100%)
		leucine-rich repeat	376..401	CDD:275380	7/24 (29%)
		LRR_RI	<401..626	CDD:238064	73/250 (29%)
		leucine-rich repeat	402..425	CDD:275380	7/22 (32%)
		leucine-rich repeat	426..449	CDD:275380	8/22 (36%)
		leucine-rich repeat	450..473	CDD:275380	9/22 (41%)
		leucine-rich repeat	474..497	CDD:275380	7/22 (32%)
		leucine-rich repeat	498..518	CDD:275380	7/38 (18%)
		leucine-rich repeat	521..544	CDD:275380	4/22 (18%)
		leucine-rich repeat	545..566	CDD:275380	7/20 (35%)
		leucine-rich repeat	569..592	CDD:275380	8/22 (36%)
		leucine-rich repeat	593..615	CDD:275380	6/21 (29%)
		leucine-rich repeat	616..637	CDD:275380	5/13 (38%)
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
LRRTM1	NP_849161.2	LRR 1	64..87		6/24 (25%)
		LRR_8	73..125	CDD:290566	14/53 (26%)
		LRR_RI	<85..268	CDD:238064	53/183 (29%)
		LRR 2	89..111		6/21 (29%)
		leucine-rich repeat	91..114	CDD:275380	7/22 (32%)
		LRR 3	112..135		7/22 (32%)
		LRR_8	113..173	CDD:290566	21/59 (36%)
		leucine-rich repeat	115..138	CDD:275380	8/22 (36%)
		LRR 4	137..159		8/21 (38%)
		leucine-rich repeat	139..162	CDD:275380	9/22 (41%)
		LRR_8	161..221	CDD:290566	13/59 (22%)
		LRR 5	161..183		6/21 (29%)
		leucine-rich repeat	163..186	CDD:275380	7/22 (32%)
		LRR 6	184..207		7/22 (32%)
		leucine-rich repeat	187..210	CDD:275380	6/22 (27%)
		LRR 7	209..231		3/21 (14%)
		leucine-rich repeat	211..234	CDD:275380	3/22 (14%)
		LRR 8	233..255		4/22 (18%)
		leucine-rich repeat	235..257	CDD:275380	4/22 (18%)
		LRR 9	256..278		8/21 (38%)
		LRR_8	257..315	CDD:290566	21/58 (36%)
		LRR_4	257..297	CDD:289563	15/39 (38%)
		leucine-rich repeat	258..281	CDD:275380	7/22 (32%)
		LRR 10	279..302		9/22 (41%)
		leucine-rich repeat	282..300	CDD:275380	8/17 (47%)
		leucine-rich repeat	306..318	CDD:275378	4/12 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	382..401
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910