DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and Toll-4

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_523519.2 Gene:Toll-4 / 34235 FlyBaseID:FBgn0032095 Length:1125 Species:Drosophila melanogaster


Alignment Length:1390 Identity:276/1390 - (19%)
Similarity:501/1390 - (36%) Gaps:448/1390 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    27 KHHQQQQLSHSNAIMGEAGVSNS-QLMQPSTPARTL------RPLTAGAGGDPSLYDAPDDCHFM 84
            :..|||||...|   .:....|| |..:.:..||.|      |.......|:..:.|.  :|   
  Fly    25 QQQQQQQLGWCN---NKDDPPNSHQKSKSNNDARNLNSRVRVRARVRVVPGEMRMGDI--NC--- 81

  Fly    85 PAAGL-----DQPEIAL-------TCNLRTVNSEFDTTNFSV------------IPAEHTIALHI 125
             :.||     |..||.|       ||::  .|:|..|.::.:            .|..|...:..
  Fly    82 -SNGLGNIREDYCEIYLDELGENGTCSI--ANNEVTTEDYQMKLVFLKLEINWTSPVFHGWNIFK 143

  Fly   126 LCND---EIMAKSRLEAQSFAHLVRLQQLSIQYCKLGRLGRQVLDG------------------- 168
            :||:   |::..|.|..:|...: |:.. ::||..|  ||.:.:.|                   
  Fly   144 ICNETDYELVIISVLGIRSEVDM-RISP-AVQYLSL--LGIREISGYDIYLPSVLITEMDVHHAN 204

  Fly   169 ------LEQLRNLTLR---THNILWPALN------------FE-----IEADAFSVTRRLERLDL 207
                  .:.|.:.|:.   |:|.:...:|            ||     :|.:.|....::..|..
  Fly   205 GPKMVTFKYLYDSTVNSVITNNYIRKTMNNTEKIKIYYHNTFEKTTLTMEKNIFHGKNKMSALIF 269

  Fly   208 SSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSS-- 270
            :...|..|.:|.|..|:.|:.|......|:|::.|          ..||..:|.|....|..:  
  Fly   270 NGLKIKGLTNNTFENLTSLNTLIFDNVFLKDLSFL----------RSSTLQSSLTYCIMKVDNMV 324

  Fly   271 --SSTSCSLDLEYLDVSH----NDFVVLPANGFGTLRRLRVLSVNNNGISMIA-----------D 318
              .|.....:||.::||.    .:|.......:.:..:..:      ||:.:|           |
  Fly   325 DLKSFEKFTNLEIIEVSQYKGFKNFTAFICEPYKSHCKFTL------GINEVACPLKCNCSYNRD 383

  Fly   319 KALSGLKNLQI----LNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQAL 379
            |:     .|:|    .||::  |.:||.......|.:     .|:|.::.|..........|::|
  Fly   384 KS-----QLEIDCWQKNLTT--IPSLPVPKKGSSALV-----FQSNLLAELPDNSLEGYHNLKSL 436

  Fly   380 DLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTF 444
            |:|.||:||..:.:..    ..|..|::.|||:|.|.|::...||::.:.|...|:..       
  Fly   437 DVSYNQLTSLSVSQLP----ESLHYLDIRHNKITTLSPQVVEYLYSVNVFNQYGNKWS------- 490

  Fly   445 APMNNLHTLLLSHNKLKYLDAYALNGL--YVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQ 507
                            .|.|.|.|...  |...||                             :
  Fly   491 ----------------IYCDEYHLQEFFWYKAKLL-----------------------------R 510

  Fly   508 LKTVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQIL 572
            :||                          |.|:.:.....|...|:::||..:.      |:..|
  Fly   511 IKT--------------------------SKFQTIMEYIELSSKGSFVENFFVQ------NIDQL 543

  Fly   573 NLARNRIAVVEPGAFE----------MTSSIQAVRLDGNELNDINGLFSNMP-------SLLW-- 618
            .|..|...:::  ||.          |.:...|:.|...|.::|.....|.|       ...|  
  Fly   544 YLEANEDEIID--AFGPSDKYFNLKLMEALNHAIWLFSGEFDEIILHHLNSPCPYRCSCCFEWHT 606

  Fly   619 ----LNISDNRLESFDYGHVPSTLQW---LDLHKNRLSSLSNRFGL--DSELKLQTLDVSFNQLQ 674
                :|..:..|:.  |..:|:::.:   |.|.:|.:..|:|...|  .....:..|.:|.|.|:
  Fly   607 GEFLINCRNLSLDI--YPRLPNSIPYKTTLYLDRNEIRKLTNTESLVVAGHASIHKLHMSQNLLR 669

  Fly   675 RIGPSSIPNSIELLFLNDNLITTVDPDTFM---HKTNLTRVDLYANQITTLDIKSLRILPVWEHR 736
            .:....:|.:|..|.:.:||:..:|.....   ::.|:|:::|                      
  Fly   670 ELPLHLLPENITYLDVRNNLLKYLDDGVIAFLEYRENITKIEL---------------------- 712

  Fly   737 ALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFL 801
                   .|||:.|:|                                :.:|::..:.   :|..
  Fly   713 -------SGNPWECNC--------------------------------KAKAFLSFLR---RHEP 735

  Fly   802 CTYKTHCFAVCHCCEFDACDCEMT---CPTNCTCFHDQTWSTN---IVECSGAAYSEMPRRVPMD 860
            ..|:|....|           |:|   ||.:|.|..|.:.|.:   :|:|||...||:| ::|..
  Fly   736 MEYETVLRRV-----------EITDDKCPEDCICCVDTSNSDSLAYVVDCSGKELSEIP-QLPTP 788

  Fly   861 TSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGN 925
            |                                     |..|        .|..|.|.:.....:
  Fly   789 T-------------------------------------YGQT--------TLVFERNSLKKWPSS 808

  Fly   926 EFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFE-----VWQLSANPYLVEIS 985
            ......::...||..|:::.|.    |:..|||.|.:..|.....:     ..|...|...:::|
  Fly   809 LLPGYSSVTRFYLAHNRLSDID----QLPDKLEYLDISNNNFSALDDRVRGFLQKRMNSSQLQLS 869

  Fly   986 LADNQWSCEC---GYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTLRDGVAHYM 1047
            |..|.|:|.|   .:|.    ::.:.::.|.:||.:.|| :...|::..:....|   ..|..|.
  Fly   870 LFGNPWTCRCEDKDFLV----FVKEQAKNIANASAIQCI-DTGRSLIEVEETDIC---PSVLIYY 926

  Fly  1048 HTNEIEGLLPLLLVATCAFVAFFGLIFGLF-CYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKER 1111
            .:..:.    ||::|         |...:| |:|..:.||.:.....::...:.     :||:::
  Fly   927 TSLAVS----LLIIA---------LSINVFICFRQPIMIWFYEHEICLSLAARR-----ELDEDK 973

  Fly  1112 PNDAYFAYSLQDEHFVNQILAQTLENDIG---YRLCLHYRDVNINAYITDALIEAAESAKQFVLV 1173
            ..||:.:::.:||..:.:.: ..|||  |   :|||.:.||..:...|.|.:.::.:.:::.:::
  Fly   974 KYDAFLSFTHKDEDLIEEFV-DRLEN--GRHKFRLCFYLRDWLVGESIPDCINQSVKGSRRIIIL 1035

  Fly  1174 LSKNFLYNEWSRFEYKSALHELVKRR-KRVVFILYGDLPQ-RDIDMDMRHYLRTSTCIEWDDKKF 1236
            ::||||.:.|.|.|::.|||...:.| ||::.:||.|:.. .|:|.::|.|:..:|.::.::..|
  Fly  1036 MTKNFLKSTWGRLEFRLALHATSRDRCKRLIVVLYPDVEHFDDLDSELRAYMVLNTYLDRNNPNF 1100

  Fly  1237 WQKLRLALP----LPNGRGNNNKRV 1257
            |.||..::|    |...|.:...:|
  Fly  1101 WNKLMYSMPHASHLKRSRSDAETKV 1125

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 6/47 (13%)
LRR_8 171..236 CDD:290566 17/84 (20%)
leucine-rich repeat 172..201 CDD:275380 9/48 (19%)
leucine-rich repeat 202..278 CDD:275380 17/79 (22%)
leucine-rich repeat 229..249 CDD:275380 4/19 (21%)
LRR_RI 278..468 CDD:238064 44/208 (21%)
leucine-rich repeat 279..302 CDD:275380 5/26 (19%)
LRR_8 301..386 CDD:290566 21/99 (21%)
leucine-rich repeat 303..326 CDD:275380 5/33 (15%)
leucine-rich repeat 327..350 CDD:275380 7/26 (27%)
LRR 350..729 CDD:227223 75/411 (18%)
leucine-rich repeat 352..375 CDD:275380 3/22 (14%)
leucine-rich repeat 376..401 CDD:275380 8/24 (33%)
LRR_RI <401..626 CDD:238064 42/249 (17%)
leucine-rich repeat 402..425 CDD:275380 9/22 (41%)
leucine-rich repeat 426..449 CDD:275380 2/22 (9%)
leucine-rich repeat 450..473 CDD:275380 4/24 (17%)
leucine-rich repeat 474..497 CDD:275380 2/22 (9%)
leucine-rich repeat 498..518 CDD:275380 2/19 (11%)
leucine-rich repeat 521..544 CDD:275380 2/22 (9%)
leucine-rich repeat 545..566 CDD:275380 4/20 (20%)
leucine-rich repeat 569..592 CDD:275380 6/32 (19%)
leucine-rich repeat 593..615 CDD:275380 6/28 (21%)
leucine-rich repeat 616..637 CDD:275380 5/26 (19%)
leucine-rich repeat 638..662 CDD:275380 6/28 (21%)
leucine-rich repeat 663..684 CDD:275380 5/20 (25%)
leucine-rich repeat 685..708 CDD:275380 5/25 (20%)
leucine-rich repeat 709..728 CDD:275380 2/18 (11%)
LRR_8 883..943 CDD:290566 8/59 (14%)
leucine-rich repeat 885..908 CDD:275380 2/22 (9%)
leucine-rich repeat 909..932 CDD:275380 3/22 (14%)
LRR_8 932..990 CDD:290566 14/62 (23%)
leucine-rich repeat 933..956 CDD:275380 5/22 (23%)
TIR 1114..1247 CDD:214587 41/141 (29%)
Toll-4NP_523519.2 leucine-rich repeat 264..287 CDD:275380 6/22 (27%)
leucine-rich repeat 288..308 CDD:275380 5/29 (17%)
leucine-rich repeat 309..334 CDD:275380 4/24 (17%)
leucine-rich repeat 335..386 CDD:275380 10/61 (16%)
leucine-rich repeat 388..408 CDD:275380 6/21 (29%)
LRR_8 412..465 CDD:290566 15/61 (25%)
leucine-rich repeat 412..432 CDD:275378 3/24 (13%)
LRR_4 432..470 CDD:289563 15/41 (37%)
leucine-rich repeat 433..454 CDD:275378 8/24 (33%)
leucine-rich repeat 455..478 CDD:275378 9/22 (41%)
leucine-rich repeat 479..490 CDD:275378 2/10 (20%)
leucine-rich repeat 632..657 CDD:275378 6/24 (25%)
leucine-rich repeat 658..679 CDD:275378 5/20 (25%)
leucine-rich repeat 680..706 CDD:275378 5/25 (20%)
leucine-rich repeat 707..719 CDD:275378 5/40 (13%)
leucine-rich repeat 771..791 CDD:275380 9/57 (16%)
leucine-rich repeat 793..815 CDD:275378 4/29 (14%)
leucine-rich repeat 816..835 CDD:275378 5/22 (23%)
leucine-rich repeat 836..859 CDD:275378 4/22 (18%)
TIR 974..1110 CDD:214587 40/138 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45453782
Domainoid 1 1.000 44 1.000 Domainoid score I4673
eggNOG 1 0.900 - - E2759_KOG4641
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
65.750

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