DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and haf

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001356954.1 Gene:haf / 33339 FlyBaseID:FBgn0261509 Length:1347 Species:Drosophila melanogaster


Alignment Length:1476 Identity:281/1476 - (19%)
Similarity:482/1476 - (32%) Gaps:443/1476 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   273 TSC----------SLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNL 327
            |||          |:..:.:|.|.   ::...|....|:.:.:|.|||:.||.:.|...|.| :|
  Fly    46 TSCICAYNLGRELSVQCDQVDFSQ---LLAAMNTHARLKPVDLLYVNNSTISELPDAVFSNL-SL 106

  Fly   328 QILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWID 392
            ..|.|||..|..:.|..|..|..:::.:.||:|.::.:..:....|.:|..||||.||::.  |.
  Fly   107 HNLQLSSCGIQRIATGAFKGQESVLRNLNLQDNLLADVPVEALKVLGKLNLLDLSKNQLSH--IP 169

  Fly   393 KNTFVGLIRLVLLNLSHNKLTKLEPEIFSDL-YTLQILNLRHNQLENIAADTFAPMNNLHTLLLS 456
            .:.||||.:|..|.|:.|.:| |....|..| .:|:.|||:..:...: .::...:.:|..|.||
  Fly   170 DDAFVGLTKLSTLKLNDNNVT-LASNAFRGLEQSLKNLNLKGTKQRKV-PESIRGLKSLAFLDLS 232

  Fly   457 HNKLKYLDA----YALNGLYVLSLLSLDNNALIGVHPDAFRNC-SALQDLNLNGNQLKTVPL-AL 515
            .|.:|.|..    ...:||..|:.|:|:.|.:..:...||... ..|..|:|..|.|...|: |:
  Fly   233 QNGIKELPGAGGIRVFDGLDALTALNLERNLIQSIGETAFAGVRKTLSSLSLLNNLLAEFPIGAV 297

  Fly   516 RNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIA 580
            .:::.||.:|:|.|::|.:.::||:|                        .|.:.:|.|..|.::
  Fly   298 HSLKELRVLDIGFNLLTSLPEAAFRG------------------------NPGITLLALDGNPLS 338

  Fly   581 VVEPGAF-EMTSSIQAVRLDGNELNDINGLFSNMPSLL-----WLNISDNRLESFD--------- 630
            .|..||| .:.::::.:.|.|.        |.:....|     |:...|.::.|.:         
  Fly   339 SVPEGAFAHLNATLRGLSLGGR--------FLHCDCKLRWVAEWIRNGDLQVTSRERNPQFCGTP 395

  Fly   631 --------YGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQ--------RIG-- 677
                    |...|..|...|:..   ::|....||...|| .||..|.:.::        .:|  
  Fly   396 PRFRDRGFYSIQPEELSCPDIAD---AALRGPVGLADNLK-PTLPSSPDSVEYETGTGTGTVGTG 456

  Fly   678 -------PSSIPNSIELLF-LNDNLITTVDPDTFMHKT-----NLTRVD---------------- 713
                   .||:.:|..... ......||.:|.|....|     :.|.:.                
  Fly   457 TAASAPVTSSVSSSTSTTTPTTTTTTTTAEPTTRRSTTRPPTKSTTTISATTASPASNPPVNGTG 521

  Fly   714 -LYANQITTLDIKSL-----------RILPVWE------------------HRALPEFYIGGNPF 748
             :.|..|||....|.           :..|.|.                  |:......:.|.|.
  Fly   522 TVQATSITTSSSSSSSSSTSTGHGNGKQAPGWRQGVTNGNGNSGVGGAGGLHKPQRPPLVLGYPP 586

  Fly   749 TCDCNIDWLQ--KINHITSRQYPRIMDLETIYCKLLNNR-------ERAYI--PLIEAEPKHFLC 802
            .....||...  ::.|...:....|:..::....:|..|       |:|:.  |.:|:..:.|..
  Fly   587 QRGTRIDDANEVQVKHAFRQDSSVIIQWDSDTANILGFRVVYRLFGEKAFKQGPPLESSEREFKI 651

  Fly   803 --TYKTHCFAVC-----------HCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSG------- 847
              .....|..||           ....:..|....|..:..:.....|.:.:...|..       
  Fly   652 KNVPAQECIIVCVISLEELHVTPETVPYQQCREVRTVASQASNMDKITIAASAAICGTIIVAVIV 716

  Fly   848 -AAYSEMPRRV--PMDTSELYIDG---NNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSG- 905
             .|.|...|::  ....|.|.|.|   |..........||  ::|.|.|.|::......:.:|| 
  Fly   717 FIAASRRSRKLQSSQQKSPLPIGGLPVNCCGPTGSPGPLG--SIATLSAFNNHKEWDQVSAYSGR 779

  Fly   906 -LKRLLILHLED-----NHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDG 964
             :.|..|..:|.     :|...:.|              :..|..|:|:|..|            
  Fly   780 SIPRPRIYPVEQPDDMRSHFSGMPG--------------KVGKSRSLADGQSQ------------ 818

  Fly   965 NRLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVL 1029
                |               |.::|.          .|.|||.:....:..||..         |
  Fly   819 ----H---------------SFSNNS----------HRGYLGSAFPSNLVNSRPE---------L 845

  Fly  1030 REKNGTKCTLRDGVAHYMHTNEIEG-----------------LLPLLLVATCAFVAFFGLIFG-- 1075
            |:...:.....:.::...:...|.|                 .||:     .:.:|..|::.|  
  Fly   846 RQSRQSLAAASERMSRASYAGSIHGGNGGGGGLGGNGGGGGNGLPV-----SSLMAMSGMVGGGG 905

  Fly  1076 -----------------------LFCYRH---ELKIWAHSTNCLMNFCYKSPRFVDQLDKERPND 1114
                                   ...:.|   .....|.||:.|.|:|..|..:.|     ...|
  Fly   906 PASIASSARRSRPRSRSREQLNTTHIHNHRPGSRYSQAGSTHTLNNYCDTSDNWTD-----HDMD 965

  Fly  1115 AYFAYSLQDEHFVNQILAQTLEN---DIGYRLCL-HYRDVNIN------AYITDALIEAAESAKQ 1169
            .|.|.:            .|..|   .: .||.|  |.:|.:|      .|:|.. ||..|...:
  Fly   966 IYMARN------------PTTRNGLVPLXGRLTLSXYFNVVLNWDGIFXQYLTPT-IEGTEGRGR 1017

  Fly  1170 FVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGDLPQRDIDMDMRHYLRTSTCIEWDD- 1233
            ......:.....:..:.:::...|:..::.:..:..|..:          ||..|.....:|:. 
  Fly  1018 GRRQQQQQQQQQQQQQQQHQQLQHQQQQQHQHQLQQLRNE----------RHQQRHRNDQQWEQP 1072

  Fly  1234 ----KKFWQKLRLALP-----------LPNGRGNNNKRVVSGCLSGRTPSVNMYATSHEYQAGNG 1283
                ::..|:|:..:|           :|.....:|....|   :|...:.|.:.:|....:...
  Fly  1073 YQPAQQQHQRLQYYMPQTERCTSPPDVVPRAANFHNSNTTS---TGHNDNSNSHGSSSSSSSNIA 1134

  Fly  1284 GVIPPPSARYADCGSNNYATINECAAAGGGRGYKPIPTSASAAAAACKFNTMNQLSKKQQRDLSV 1348
            .....|.|...       |.:.:..||.         |:|:||||:.....:.....:.:|...:
  Fly  1135 QQQQAPLAAMT-------AALGDATAAA---------TAAAAAAASASGIVVENYFNEYERQEII 1183

  Fly  1349 AGMAKTLEHQHHHNHQANRRSQHEYA---------VPS------YLPSAAPAYDSVDYAKQQIRN 1398
                        ::|..:|||....:         ||.      .||:.|.|             
  Fly  1184 ------------YHHPTSRRSSSSSSSCSAAATRHVPRSNAFRLQLPAVATA------------- 1223

  Fly  1399 NANCECVNLGTAKRAAGKNPASG--LPSSFSSNFVPPGGASYNCKKSCSCIGDDEL-------LC 1454
            ..|....|:.....|.|.|.:.|  ...:||.        |.||..:||...::|:       ..
  Fly  1224 TTNNILYNISNKHGATGHNGSIGNYKAHTFSD--------SCNCTCNCSLSEEEEISQETAAVTA 1280

  Fly  1455 SCGGGGGIGVNLLESGTQSSVTMSSSSNNSRQPELTHYESNLSLND 1500
            :.|..|....:.|.|.:.||:.........:|.:..:...||:|.|
  Fly  1281 AAGEDGDQAGSSLSSTSVSSIEQVQQGQQEQQGQEVYLSLNLTLAD 1326

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380 4/14 (29%)
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 57/194 (29%)
leucine-rich repeat 279..302 CDD:275380 4/22 (18%)
LRR_8 301..386 CDD:290566 28/84 (33%)
leucine-rich repeat 303..326 CDD:275380 9/22 (41%)
leucine-rich repeat 327..350 CDD:275380 9/22 (41%)
LRR 350..729 CDD:227223 101/459 (22%)
leucine-rich repeat 352..375 CDD:275380 4/22 (18%)
leucine-rich repeat 376..401 CDD:275380 12/24 (50%)
LRR_RI <401..626 CDD:238064 57/237 (24%)
leucine-rich repeat 402..425 CDD:275380 8/23 (35%)
leucine-rich repeat 426..449 CDD:275380 4/22 (18%)
leucine-rich repeat 450..473 CDD:275380 9/26 (35%)
leucine-rich repeat 474..497 CDD:275380 6/23 (26%)
leucine-rich repeat 498..518 CDD:275380 7/20 (35%)
leucine-rich repeat 521..544 CDD:275380 9/22 (41%)
leucine-rich repeat 545..566 CDD:275380 0/20 (0%)
leucine-rich repeat 569..592 CDD:275380 7/23 (30%)
leucine-rich repeat 593..615 CDD:275380 3/21 (14%)
leucine-rich repeat 616..637 CDD:275380 6/42 (14%)
leucine-rich repeat 638..662 CDD:275380 5/23 (22%)
leucine-rich repeat 663..684 CDD:275380 6/37 (16%)
leucine-rich repeat 685..708 CDD:275380 5/28 (18%)
leucine-rich repeat 709..728 CDD:275380 6/46 (13%)
LRR_8 883..943 CDD:290566 11/66 (17%)
leucine-rich repeat 885..908 CDD:275380 6/24 (25%)
leucine-rich repeat 909..932 CDD:275380 4/27 (15%)
LRR_8 932..990 CDD:290566 7/57 (12%)
leucine-rich repeat 933..956 CDD:275380 5/22 (23%)
TIR 1114..1247 CDD:214587 25/158 (16%)
hafNP_001356954.1 LRR <52..>252 CDD:227223 59/207 (29%)
leucine-rich repeat 86..105 CDD:275380 9/19 (47%)
leucine-rich repeat 106..129 CDD:275380 9/22 (41%)
LRR_8 131..189 CDD:338972 20/59 (34%)
leucine-rich repeat 131..154 CDD:275380 4/22 (18%)
leucine-rich repeat 155..178 CDD:275380 12/24 (50%)
leucine-rich repeat 179..202 CDD:275380 8/23 (35%)
leucine-rich repeat 203..225 CDD:275380 4/22 (18%)
leucine-rich repeat 226..253 CDD:275380 9/26 (35%)
LRR_8 254..337 CDD:338972 26/106 (25%)
leucine-rich repeat 254..302 CDD:275380 13/47 (28%)
leucine-rich repeat 303..326 CDD:275380 9/46 (20%)
leucine-rich repeat 327..350 CDD:275380 7/22 (32%)
PCC 332..>413 CDD:188093 16/88 (18%)
PRK10927 <1061..>1097 CDD:236797 5/35 (14%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
10.910

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