DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-6 and lgi1a

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_955921.2	Gene:	lgi1a / 323011	ZFINID:	ZDB-GENE-030131-1731	Length:	537	Species:	Danio rerio

Alignment Length:	465	Identity:	91/465 - (19%)
Similarity:	167/465 - (35%)	Gaps:	101/465 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   826 CPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYA 890
            ||..|||..|.....|    :||    :||..|.|...|....:.|.|:...||:....|.:|..
Zfish    28 CPAPCTCSKDNALCAN----TGA----IPRSFPQDVISLSFVKSGFTEIPKESFIHTPALHLLLF 84

  Fly   891 NNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLR 955
            ..::...|....|.||..|..|.:|:|.|.|:....|..|::|..|.|..|.:.::....|:.:.
Zfish    85 TANSFDSINEDAFLGLPHLEYLFIENNQIKSISPFAFRGLKSLIHLSLAYNNLETLPKDLFKGME 149

  Fly   956 KLEVLRLDGN------RLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKI-- 1012
            .|..:.|.||      :|.....|....|..:.:|.....:               |...:||
Zfish   150 ALTKVDLRGNLFSCDCKLKWLVDWMFHTNATVDQIFCNGPE---------------GYQGKKIND 199

  Fly  1013 IDASRVSCIYNNAT----------------------SVLREKNGTKCTLRDGVAHYMHTNEIEGL 1055
            ::|....||..:.|                      .|..:....:|:..:.....|.....:.:
Zfish   200 LEAQTFDCITTDFTLLKSLEFQSISVEAFSFAGDQFVVFAQPFSGRCSFMEWDHVQMEFRNFDNI 264

  Fly  1056 LPL-------LLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPN 1113
            ...       |::.:..|:....|..|...::.::     |.|..:..     :.:|.|...:||
Zfish   265 TSTSTVICKPLVIDSQLFIIVAQLFGGSHIFKRDV-----SANKFIRI-----QDIDILKIRKPN 319

  Fly  1114 DAYFAYSLQDEHFVNQILAQTLE---------NDIGYRLCLHYRDVNINAYITDALIEAAESAKQ 1169
            |... :.:..|.|.  |:|.:.:         |..|:     |...:::.:..|..:|..:.:.:
Zfish   320 DVEI-FEVDGESFF--IIADSSKAGSTTIYKWNGNGF-----YSYQSLHPWHRDTDVEYLDISGK 376

  Fly  1170 FVLVLSKN----FLYNEWSR----FEYKSALHELVKRRKRVVFILYGDLPQRDIDMDMRHYLRTS 1226
            ..|:||.:    .:| :|||    ||.::.:.|:     ..||.:.....:.::.:.:..::..|
Zfish   377 PHLILSSSSQRPVVY-QWSRGSAQFERRTDIPEM-----EDVFAVKHFTVKNELYICLTRFIGDS 435

  Fly  1227 TCIEWDDKKF 1236
            ..:.||...|
Zfish   436 KVMRWDGSMF 445

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR	350..729	CDD:227223
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		LRR_RI	<401..626	CDD:238064
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	426..449	CDD:275380
		leucine-rich repeat	450..473	CDD:275380
		leucine-rich repeat	474..497	CDD:275380
		leucine-rich repeat	498..518	CDD:275380
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..566	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		leucine-rich repeat	593..615	CDD:275380
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566	18/59 (31%)
		leucine-rich repeat	885..908	CDD:275380	6/22 (27%)
		leucine-rich repeat	909..932	CDD:275380	8/22 (36%)
		LRR_8	932..990	CDD:290566	13/63 (21%)
		leucine-rich repeat	933..956	CDD:275380	5/22 (23%)
		TIR	1114..1247	CDD:214587	26/140 (19%)
lgi1a	NP_955921.2	LRR_8	57..113	CDD:290566	15/55 (27%)
		LRR_4	77..120	CDD:289563	12/42 (29%)
		leucine-rich repeat	79..102	CDD:275378	6/22 (27%)
		LRR_8	101..161	CDD:290566	17/59 (29%)
		LRR_4	101..141	CDD:289563	12/39 (31%)
		leucine-rich repeat	103..126	CDD:275378	8/22 (36%)
		leucine-rich repeat	127..150	CDD:275378	5/22 (23%)
		leucine-rich repeat	151..163	CDD:275378	4/11 (36%)
		TPKR_C2	159..207	CDD:301599	9/62 (15%)
		EPTP	211..252	CDD:281697	3/40 (8%)
		EPTP	257..298	CDD:281697	4/40 (10%)
		EPTP	303..349	CDD:281697	9/53 (17%)
		EPTP	352..394	CDD:281697	8/47 (17%)
		EPTP	399..441	CDD:281697	6/46 (13%)
		EPTP	444..485	CDD:281697	1/2 (50%)
		EPTP	490..530	CDD:281697
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000