DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and Tlr7

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	XP_017457568.1	Gene:	Tlr7 / 317468	RGDID:	1563357	Length:	1068	Species:	Rattus norvegicus

Alignment Length:	1285	Identity:	273/1285 - (21%)
Similarity:	463/1285 - (36%)	Gaps:	412/1285 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 LTCNLRTVNSEFDTTNFSVIPAEHTIALHILCNDEIMAKSRLEAQSFAHLVRLQQLSIQYCKLGR 160
            |.|::     ..|:||..||         :.|.|:             ||.
  Rat    52 LPCDV-----SLDSTNTHVI---------VDCTDK-------------HLT-------------- 75

  Fly   161 LGRQVLDGL-EQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSN----------NIWS 214
               ::.:|: ....||||..::|  |:    |..|:|...:.||.|||..|          |:.:
  Rat    76 ---EIPEGIPTNTTNLTLTINHI--PS----ISPDSFHRLKHLEELDLRCNCVPILLGSKANVCT 131

  Fly   215 ----LPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSC 275
                :....|..||:|.:|.:..|:|.::.:    |........|.|:.:.....|::.|.
  Rat   132 KRLQIRPGSFSGLSDLKSLYLDGNQLLEIPQ----DLPSSLQLLSLEANNIFSITKENLSE---- 188

  Fly   276 SLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADK-ALSGLKNLQILNLSSNKIVA 339
            .:::|.|.:..|.:...|.|                 :|...:| |...:|||::|:|..|.:.|
  Rat   189 LVNIESLYLGQNCYYRNPCN-----------------VSYSIEKDAFLVMKNLKVLSLKDNNVTA 236

  Fly   340 LPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMN---------QITSTWIDKNT 395
            :||.|    ...:.|:||.||.|..:....|:.|.|||.||||.|         ..|.
  Rat   237 VPTIL----PPNLLELYLYNNIIKRIQEHDFNKLSQLQVLDLSGNCPRCYNVPYPCTP------- 290

  Fly   396 FVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKL 460
                       ..:|...::....|..|..|::|.|..|.|:::.|:.|..|:||..|.||.|.|
  Rat   291 -----------CENNSPLQIHDNAFDSLTELKVLRLHSNSLQHVPAEWFKNMSNLQELDLSQNYL 344

  Fly   461 --KYLDAYALNGLYVLSLLSLDNNALIGVH------PDAFRNCSALQDLNLNG---NQLKTVPLA 514
              :..:|..||.|..|..|.|..|..:.|:      |.:..:.:.|::|.:.|   .:||...|:
  Rat   345 AREIEEAKFLNSLPNLVQLDLSFNYELQVYHASITLPHSLSSLTKLKNLYIKGYVFKELKDSSLS 409

  Fly   515 -LRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGN------------------------- 553
             |.|:.:|..:|||.|.|.:.:.:.|:...||..:.|..|
  Rat   410 VLHNLSNLEVLDLGTNFIKIADLNIFQQFENLKFIDLSVNKISPSEESREVGLCPNAQTSVDWHG 474

  Fly   554 --YLENITMHTFR-------------DLPNL-----------QILNLARNRIAVVEPGAFEMTSS 592
              .||  .:|.||             :.|..           :.|:|:||.|..::|..|:..|.
  Rat   475 PQVLE--ALHYFRYDEYARSCRFKNKEPPTFLPLNADCHTYGKTLDLSRNNIFFIKPSDFKHLSF 537

  Fly   593 IQAVRLDGNELND-INGL-FSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRF 655
            ::.:.|.||.:.. :||. ...:..|.:|:.|:|||:.              |:......|.|
  Rat   538 LKCLNLSGNAIGQTLNGSELQPLRELRYLDFSNNRLDL--------------LYSTAFEELQN-- 586

  Fly   656 GLDSELKLQTLDVSFNQ--LQRIGPSSIPN------SIELLFLNDNLITTVDPDTFMHKTNLTRV 712
                   |:.||:|.|.  .|..|.:.:.|      .:|.|.:|||
  Rat   587 -------LEILDLSSNSHYFQAEGITHMLNFTKKLRHLEKLMMNDN------------------- 625

  Fly   713 DLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETI 777
            |:..:...|::.:|||:|         ||  .||    ..::.|....|        |.:|   .
  Rat   626 DISTSASRTMESESLRVL---------EF--RGN----HLDVLWRDGDN--------RYLD---F 664

  Fly   778 YCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNI 842
            :..|||..|
  Rat   665 FKNLLNLEE-------------------------------------------------------- 673

  Fly   843 VECSGAAYSEMPRRV----PMDTSELYIDGNNFVELAGHSF-LGRKNLAVLYANNSNVAHIYNTT 902
            ::.|..:.:.:|..|    |.:.:.|.:..|..     .|| .||..| :.:..|.:::|...||
  Rat   674 LDISRNSLNSVPPGVFEGMPPNLTTLSLAKNGL-----RSFSWGRLQL-LKHLKNLDLSHNQLTT 732

  Fly   903 F--------SGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSF--QMLRKL 957
            .        ..|.:|::.|   |.|..|......:...||.|.:.||||..|...||  .:|..|
  Rat   733 VPARLANCSKSLTKLILNH---NQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNL 794

  Fly   958 EVLRLDGNRLM-----HFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEK---IID 1014
            .:|.|..||.:     .:.||.:             |.......|||......|..:.|   :|.
  Rat   795 NMLLLHHNRFLCNCDAVWFVWWV-------------NHTDVTIPYLATDVTCAGPGAHKGQSVIS 846

  Fly  1015 ASRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGLFCY 1079
            ....:|..:....:|                  .:..|..:|.|::|.|.:.:.|:.:.:..:.:
  Rat   847 LDLYTCELDLTNLIL------------------FSVSISSVLFLMIVMTTSHLFFWDMWYIYYFW 893

  Fly  1080 RHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDE---HFVNQILAQTLEN--DI 1139
            :.::|.:.|..:  |..||               ||:..|..::.   .:|.|.|...||:  :.
  Rat   894 KAKIKGYQHLQS--MESCY---------------DAFIVYDTKNSAVTEWVLQELVVKLEDPREK 941

  Fly  1140 GYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVVF 1204
            .:.|||..||......:.:.|.::.:.:::.|.|:::.:...|..:..:..:...|:..:..|:.
  Rat   942 HFNLCLEERDWLPGQPVLENLSQSIQLSRKTVFVMTQKYAKTESFKMAFYLSHQRLMDEKVDVII 1006

  Fly  1205 ILYGDLP-QRDIDMDMRHYLRTSTCIEWDDKK-----FWQKLRLALPLPN 1248
            :::.:.| |:...:.:|..|.:|:.:||....     |||.|:.||...|
  Rat  1007 LIFLEKPLQKSKFLQLRKRLCSSSVLEWPTNPQAHPYFWQCLKNALTTDN 1056

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380	1/23 (4%)
		LRR_8	171..236	CDD:290566	22/78 (28%)
		leucine-rich repeat	172..201	CDD:275380	9/28 (32%)
		leucine-rich repeat	202..278	CDD:275380	19/89 (21%)
		leucine-rich repeat	229..249	CDD:275380	4/19 (21%)
		LRR_RI	278..468	CDD:238064	54/201 (27%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	301..386	CDD:290566	29/94 (31%)
		leucine-rich repeat	303..326	CDD:275380	3/23 (13%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		LRR	350..729	CDD:227223	109/460 (24%)
		leucine-rich repeat	352..375	CDD:275380	8/22 (36%)
		leucine-rich repeat	376..401	CDD:275380	8/33 (24%)
		LRR_RI	<401..626	CDD:238064	70/289 (24%)
		leucine-rich repeat	402..425	CDD:275380	3/22 (14%)
		leucine-rich repeat	426..449	CDD:275380	8/22 (36%)
		leucine-rich repeat	450..473	CDD:275380	10/24 (42%)
		leucine-rich repeat	474..497	CDD:275380	6/28 (21%)
		leucine-rich repeat	498..518	CDD:275380	7/23 (30%)
		leucine-rich repeat	521..544	CDD:275380	7/22 (32%)
		leucine-rich repeat	545..566	CDD:275380	8/60 (13%)
		leucine-rich repeat	569..592	CDD:275380	7/33 (21%)
		leucine-rich repeat	593..615	CDD:275380	5/23 (22%)
		leucine-rich repeat	616..637	CDD:275380	6/20 (30%)
		leucine-rich repeat	638..662	CDD:275380	3/23 (13%)
		leucine-rich repeat	663..684	CDD:275380	8/28 (29%)
		leucine-rich repeat	685..708	CDD:275380	5/22 (23%)
		leucine-rich repeat	709..728	CDD:275380	3/18 (17%)
		LRR_8	883..943	CDD:290566	16/67 (24%)
		leucine-rich repeat	885..908	CDD:275380	6/30 (20%)
		leucine-rich repeat	909..932	CDD:275380	5/22 (23%)
		LRR_8	932..990	CDD:290566	18/64 (28%)
		leucine-rich repeat	933..956	CDD:275380	11/24 (46%)
		TIR	1114..1247	CDD:214587	32/143 (22%)
Tlr7	XP_017457568.1	leucine-rich repeat	66..87	CDD:275380	6/59 (10%)
		LRR_8	93..157	CDD:290566	18/69 (26%)
		leucine-rich repeat	109..146	CDD:275380	9/36 (25%)
		leucine-rich repeat	147..191	CDD:275380	9/51 (18%)
		leucine-rich repeat	192..223	CDD:275380	8/47 (17%)
		LRR_8	222..277	CDD:290566	25/58 (43%)
		LRR_RI	223..472	CDD:238064	73/270 (27%)
		leucine-rich repeat	224..244	CDD:275380	8/23 (35%)
		leucine-rich repeat	245..268	CDD:275380	8/22 (36%)
		leucine-rich repeat	269..309	CDD:275380	11/57 (19%)
		LRR_8	308..368	CDD:290566	22/59 (37%)
		leucine-rich repeat	310..333	CDD:275380	8/22 (36%)
		leucine-rich repeat	334..359	CDD:275380	10/24 (42%)
		leucine-rich repeat	370..389	CDD:275380	2/18 (11%)
		leucine-rich repeat	390..416	CDD:275380	8/25 (32%)
		leucine-rich repeat	417..440	CDD:275380	7/22 (32%)
		LRR_8	515..573	CDD:290566	17/57 (30%)
		leucine-rich repeat	515..537	CDD:275380	7/21 (33%)
		LRR_RI	532..778	CDD:238064	73/378 (19%)
		leucine-rich repeat	538..562	CDD:275380	5/23 (22%)
		LRR_8	561..627	CDD:290566	22/107 (21%)
		leucine-rich repeat	563..586	CDD:275380	8/36 (22%)
		leucine-rich repeat	587..616	CDD:275380	8/28 (29%)
		leucine-rich repeat	617..639	CDD:275380	7/40 (18%)
		LRR_8	639..706	CDD:290566	22/148 (15%)
		leucine-rich repeat	640..670	CDD:275380	12/55 (22%)
		leucine-rich repeat	671..695	CDD:275380	5/79 (6%)
		LRR_8	694..754	CDD:290566	15/68 (22%)
		leucine-rich repeat	696..719	CDD:275380	7/28 (25%)
		leucine-rich repeat	720..743	CDD:275380	4/22 (18%)
		leucine-rich repeat	768..786	CDD:275380	8/17 (47%)
		TIR	909..1054	CDD:214587	34/159 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780