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Protein Alignment Toll-6 and Tlr2

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	XP_008759324.3	Gene:	Tlr2 / 310553	RGDID:	735138	Length:	831	Species:	Rattus norvegicus

Alignment Length:	1021	Identity:	222/1021 - (21%)
Similarity:	388/1021 - (38%)	Gaps:	271/1021 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   301 RRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELF----AEQAKIIQEVYLQNNS 361
            |.||.....:.|.|::....:||...|.:.:         .|.|:    .:..:::|.::|....
  Rat     3 RGLRSSGWRSPGASLLCFSFISGASELHLWS---------ETALWKLQRVKSQRMLQALWLFWIL 58

  Fly   362 ISVL-------NPQLFSNLDQLQALDLSMNQITS--TWIDKNTFVGLIRLVLLNLSHNKLTKLEP 417
            ::|:       :.|...:.|.....|.|....||  :.:..||       ..|:||.||:|.:..
  Rat    59 MAVIGLSREGHSAQASLSCDAAGVCDGSSRSFTSIPSGLTANT-------KKLDLSFNKITYIGH 116

  Fly   418 EIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNN 482
            ........|::|.|..:.:..|..|.|..:.:|..|.||:|.|..|.:
  Rat   117 GDLRACVNLRVLTLESSGINTIEGDAFYSLGSLEHLDLSNNHLSSLSS----------------- 164

  Fly   483 ALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYG 547
                   ..||..|:|:.|||.||..:|               |||.       |.|..|.||..
  Rat   165 -------SWFRPLSSLKYLNLMGNPYRT---------------LGET-------SLFSNLTNLQN 200

  Fly   548 LRLIGNYLENITMHTFRDLPNLQ---ILNLARNRIAVVEPGAFEMTSSIQAVR------LDGNEL 603
            || :||      :.||.::..:.   :.:|....|.|:..|.:| :.|:|::|      |..:|.
  Rat   201 LR-VGN------VDTFSEIRRIDFAGLTSLNELEIQVLSLGNYE-SRSLQSIRDIYHLTLHLSES 257

  Fly   604 NDINGLFSN-MPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGL-DSELKLQTL 666
            ..:.|:|:: :.|:.:|.:.|..|..|         |:.:|..:.::|...:... :::|    .
  Rat   258 AFLLGIFADILSSVRYLELRDTNLARF---------QFSELSVDEINSPMKKLAFRNADL----T 309

  Fly   667 DVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLY--ANQITTLDIKSLRI 729
            |.|||:|.::    :...:||:.:..:..|......|    |.:..|:.  ..::.|:.|:||.|
  Rat   310 DKSFNELLKL----LRYILELMEVEFDHCTLNGVGNF----NPSESDVVRELGKVETVTIRSLHI 366

  Fly   730 LPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIE 794
                     |:||:                           ..||.|:| .||...:|..:
  Rat   367 ---------PQFYL---------------------------FYDLSTVY-SLLEKVKRITV---- 390

  Fly   795 AEPKHFL--CTYKTHCFAVCHCCEF-DACDCEMT--CPTNCTCFHDQTWSTNIVECSGAAYSEMP 854
            ...|.||  |::..|..::    || |..:..|.  ...|..|  :..|.:    ......|:..
  Rat   391 ENSKVFLVPCSFSQHLKSL----EFLDLSENLMVEEYLKNSAC--EGGWPS----LQSLVLSQNH 445

  Fly   855 RRVPMDTSELYIDGNNF--VELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDN 917
            .|....|:|:.:...|.  ::::.:||....: :..:.......::.:|....:|..:...||
  Rat   446 LRSIRKTAEILLTLKNLTALDISKNSFQPMPD-SCQWPGKMRFLNLSSTGIQAVKTCIPQTLE-- 507

  Fly   918 HIISLEGNEFHN----LENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSAN 978
             ::.:..|...:    |..|:|||:..||:.::...|  :...|:|:::..|.:..|...||.:.
  Rat   508 -VLDVSNNNLDSFSLFLPRLQELYISRNKLKTLPEAS--LFPVLQVMKIRENAISTFSKDQLGSF 569

  Fly   979 PYLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTLRDGV 1043
            |.|..:...||.:.|.|..|                            |.:.|:......|.|..
  Rat   570 PKLETLEAGDNHFICSCELL----------------------------SFILERPALVHVLVDWP 606

  Fly  1044 AHY-------MHTNEIEGLLP--------LLLVATCAFVAFFGLIFGLFCYR-HEL----KIWA- 1087
            ..|       :|...::...|        .|:...|..:....|:.|..||. |.|    .:||
  Rat   607 DSYLCDSPPRLHGQRLQDARPSVLECHQAALVSGVCCALLLLILLLGALCYHFHGLWYLRMMWAW 671

  Fly  1088 -------HSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLEN-DIGYRLC 1144
                   ....| .:.||               ||:.:||.||.::|..::.|.||| |..::||
  Rat   672 LRAKRKPKKAPC-RDLCY---------------DAFVSYSEQDSYWVENLMVQQLENSDPPFKLC 720

  Fly  1145 LHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGD 1209
            ||.||.....:|.|.:|::.|.:.:.|.|||:||:.:||.::|...:...|.........::..:
  Rat   721 LHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCKYELDFSHFRLFDENNDAAILVLLE 785

  Fly  1210 ------LPQRDIDMDMRHYLRTSTCIEW--DD---KKFWQKLRLAL 1244
                  :|||  ...:|..:.|.|.:||  |:   :.||..||.|:
  Rat   786 PIEKKAIPQR--FCKLRKIMNTKTYLEWPLDEGQREVFWANLRTAI 829

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.