DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and Lgi3

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001100747.1 Gene:Lgi3 / 306013 RGDID:1311079 Length:548 Species:Rattus norvegicus


Alignment Length:500 Identity:98/500 - (19%)
Similarity:169/500 - (33%) Gaps:144/500 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   826 CPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYA 890
            ||.:|:|..|..:..:        ...:|:.:|.:...|.:....|.|:...:|.....|..|..
  Rat    39 CPPSCSCTRDTAFCVD--------SKSVPKNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLL 95

  Fly   891 NNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLR 955
            |::....|.:..|:||..|..|.:|:|.|..|....|..|::|..|.|.:|.:.::....|:.|.
  Rat    96 NSNKFTLIGDNAFTGLSHLQYLFIENNDIWGLSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLD 160

  Fly   956 KLEVLRLDGN------RLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKIID 1014
            .|..|.|.||      ::.....|....|..:..|         .|....||:.:..|.    :.
  Rat   161 ILSDLDLRGNALNCDCKVKWLVEWLAHTNTTVAPI---------YCASPPRFQEHKVQD----LP 212

  Fly  1015 ASRVSCIYNN----------ATS------------VLREKNGTKCT----------LRD------ 1041
            .....||..:          |.|            .|.:...:.||          |||      
  Rat   213 LREFDCITTDFVLYQTLSFPAVSAEPFLYSSDLYLALAQPGASACTILKWDYVERQLRDYDRIPA 277

  Fly  1042 GVAHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRF--V 1104
            ..|.:.....::|.|         :|....|..|.:.|.     |..:|.          ||  :
  Rat   278 PSAVHCKPMVVDGQL---------YVVVAQLFGGSYIYH-----WDPNTT----------RFTKL 318

  Fly  1105 DQLDKER---PNDAYFAYSLQDEHFV-----NQILAQTL----ENDIGYRLCLH--YRDVNINAY 1155
            ..:|.:|   |||.. |:.:..:.|.     ::..|.:|    :|.......||  :||.::.  
  Rat   319 QDIDPQRVRKPNDLE-AFRIDGDWFFAVADSSKAGATSLYRWHQNGFYSHQALHAWHRDTDLE-- 380

  Fly  1156 ITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGDLPQ-------- 1212
                .::.....:..|...|:..:..:|||.:.:              |:..|::.|        
  Rat   381 ----FVDGEGKPRLIVSSSSQAPVIYQWSRTQKQ--------------FVAQGEVTQVPDAQAVK 427

  Fly  1213 -----RDIDMDMRHYLRTSTCIEWDDKKFWQKLRLALPLPNGRGN 1252
                 ||..:.:..|:..|..:.|:..:|.:.  .|||   .||:
  Rat   428 HFRAGRDSYLCLSRYIGDSKILRWEGTRFSEV--QALP---SRGS 467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064
leucine-rich repeat 279..302 CDD:275380
LRR_8 301..386 CDD:290566
leucine-rich repeat 303..326 CDD:275380
leucine-rich repeat 327..350 CDD:275380
LRR 350..729 CDD:227223
leucine-rich repeat 352..375 CDD:275380
leucine-rich repeat 376..401 CDD:275380
LRR_RI <401..626 CDD:238064
leucine-rich repeat 402..425 CDD:275380
leucine-rich repeat 426..449 CDD:275380
leucine-rich repeat 450..473 CDD:275380
leucine-rich repeat 474..497 CDD:275380
leucine-rich repeat 498..518 CDD:275380
leucine-rich repeat 521..544 CDD:275380
leucine-rich repeat 545..566 CDD:275380
leucine-rich repeat 569..592 CDD:275380
leucine-rich repeat 593..615 CDD:275380
leucine-rich repeat 616..637 CDD:275380
leucine-rich repeat 638..662 CDD:275380
leucine-rich repeat 663..684 CDD:275380
leucine-rich repeat 685..708 CDD:275380
leucine-rich repeat 709..728 CDD:275380
LRR_8 883..943 CDD:290566 19/59 (32%)
leucine-rich repeat 885..908 CDD:275380 7/22 (32%)
leucine-rich repeat 909..932 CDD:275380 8/22 (36%)
LRR_8 932..990 CDD:290566 14/63 (22%)
leucine-rich repeat 933..956 CDD:275380 6/22 (27%)
TIR 1114..1247 CDD:214587 27/156 (17%)
Lgi3NP_001100747.1 LRR_8 68..124 CDD:290566 15/55 (27%)
leucine-rich repeat 68..89 CDD:275378 4/20 (20%)
leucine-rich repeat 90..113 CDD:275378 7/22 (32%)
LRR_8 112..172 CDD:290566 19/59 (32%)
LRR_4 113..152 CDD:289563 12/38 (32%)
leucine-rich repeat 114..137 CDD:275378 8/22 (36%)
LRR 135..158 CDD:197688 6/22 (27%)
leucine-rich repeat 138..161 CDD:275378 6/22 (27%)
leucine-rich repeat 162..174 CDD:275378 5/11 (45%)
TPKR_C2 170..218 CDD:301599 8/60 (13%)
EPTP 222..263 CDD:281697 5/40 (13%)
EPTP 268..309 CDD:281697 10/54 (19%)
EPTP 314..359 CDD:281697 11/45 (24%)
EPTP 363..405 CDD:281697 6/47 (13%)
EPTP 410..452 CDD:281697 7/55 (13%)
EPTP 455..496 CDD:281697 6/17 (35%)
EPTP 501..541 CDD:281697
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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