DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and Tlr6

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_997487.1	Gene:	Tlr6 / 305353	RGDID:	1303030	Length:	806	Species:	Rattus norvegicus

Alignment Length:	978	Identity:	216/978 - (22%)
Similarity:	378/978 - (38%)	Gaps:	267/978 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 IVALPTELFAEQAKIIQEVYLQNNSISV---LNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVG 398
            ||...|:...|...::.  |...|...|   |:|       ..::|.||.|.|:...:...:|:.
  Rat    32 IVGSMTQFSDELESVVD--YSNKNLTHVPKDLSP-------STKSLSLSQNSISDLQMSDISFLS 87

  Fly   399 LIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYL 463
            .:|  :|.||||::.:|:..:|.....|:.|::.||||:||:.   .||.||..|.||.|..:.|
  Rat    88 ELR--VLRLSHNRIRRLDFGVFLLNRDLEYLDVSHNQLQNISC---CPMVNLKHLDLSFNDFEVL 147

  Fly   464 DAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGE 528
            ..|...|       :|...:.:|:....||             ||..:|::     ||
  Rat   148 PVYKEFG-------NLRKLSFLGLSAAKFR-------------QLDLLPIS-----HL------- 180

  Fly   529 NMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSI 593
            ::..|:.|        |...::.....|::      .:||..:|:|      |..|
  Rat   181 HLSCVLLD--------LVNYQIKDGETESL------QVPNTNVLHL------VFHP--------- 216

  Fly   594 QAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHV---PSTLQWLDLHKNRLS---SLS 652
                         |.|||     :.:|||.|.|......::   ....|.|.:..:.|:   :|.
  Rat   217 -------------NSLFS-----VQVNISVNALGCLQLSNIKLNDENCQSLIIFLSELTRGPTLL 263

  Fly   653 NRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLIT-TVDPDTFMHKTNLTRVDLYA 716
            |       |.||.::.::....|:.....|..:|.|.:.:..|| ::..:||::
  Rat   264 N-------LTLQHIETNWKCFVRLLQFLWPRPVEYLNIYNLTITESISRETFIY----------- 310

  Fly   717 NQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMD-LETIYCK 780
              :.|: :|||                               ||.|:|::.:..:.| |.:::.:
  Rat   311 --VETV-LKSL-------------------------------KIEHVTNQVFLFVKDALYSVFAE 341

  Fly   781 LLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVE- 844
             :|.|   .:.|.:....|.:|......||..:                   |....::.:|.:
  Rat   342 -MNIR---MLTLSDTPFIHMVCPEFPSTFAFLN-------------------FTQNVFTDSIFQG 383

  Fly   845 CSGAAYSEMPRRVPMDTSELYIDG-NNFVELAGHSFLGRKNLAVL----YANNSNVAHIYNTTFS 904
            |     |.:.|   ::|..|..:| .|..::|    |..|.::.|    .:.||..:|:|:.|.:
  Rat   384 C-----STLKR---LETLILQRNGLKNLFKVA----LMTKTMSSLETLDVSLNSLNSHVYDRTCA 436

  Fly   905 GLK----------------------RLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIA 947
            ..:                      ::.:|.|.:|.|:|:..:..| |:.|:||.:.||.:..:.
  Rat   437 WAESIRVLNLSSNVLSDSVFRCLPPKVKVLDLHNNRIVSIPKDVTH-LQALQELNVASNFLTDLP 500

  Fly   948 N-GSFQMLRKLEVLRLDGNRLMH--FEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSS 1009
            . |:|.   .|.||.:|.|.:.|  .:.:|...|  :..|:..:|.:.|.| .|..|...:||:|
  Rat   501 GCGAFS---SLSVLVIDHNSVSHPSSDFFQSCQN--IRSITAGNNPFRCTC-ELREFVKNIGQAS 559

  Fly  1010 EKIIDA--SRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEG---LLPLLLVATCAFVAF 1069
            .::::.  ....|.|.::.      .||  .|:|     .|.:.:..   ||.:.:.||...:|.
  Rat   560 REVVEGWPDSYRCDYPDSI------KGT--PLQD-----FHMSPLSCDTILLTVTIGATLLLLAA 611

  Fly  1070 FG----LIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQI 1130
            .|    |.|.|..|...|..|..:.:...|.    |  :::|.:.....|:.:||..|..:|...
  Rat   612 IGASLCLYFDLPWYLRMLWQWTQTRHRARNI----P--LEELQRNLQFHAFVSYSEHDSAWVKNE 670

  Fly  1131 LAQTLENDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHEL 1195
            |...||.| ..|:|||.|:......|.:.:|...|.:.:.:.|||.:|:.:||..:|...|.|.|
  Rat   671 LLPNLEKD-DIRVCLHERNFVPGKSIVENIIHFIEKSYKSIFVLSPHFIQSEWCHYELYFAHHNL 734

  Fly  1196 V-KRRKRVVFILYGDLPQRDIDM---DMRHYLRTSTCIEWDDKK-----FWQKLRLALPLPNGRG 1251
            . :....::.||...:.|.:|..   .:|..:...|.:||..:|     ||..||.:..:.....
  Rat   735 FHEGSDNLILILLEPIQQNNIPSRYHKLRALMAQRTYLEWPIEKGKRGLFWANLRASFIMKLALV 799

  Fly  1252 NNN 1254
            |.|
  Rat   800 NEN 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	41/133 (31%)
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566	13/51 (25%)
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380	4/12 (33%)
		LRR	350..729	CDD:227223	86/388 (22%)
		leucine-rich repeat	352..375	CDD:275380	5/25 (20%)
		leucine-rich repeat	376..401	CDD:275380	6/24 (25%)
		LRR_RI	<401..626	CDD:238064	54/224 (24%)
		leucine-rich repeat	402..425	CDD:275380	7/22 (32%)
		leucine-rich repeat	426..449	CDD:275380	10/22 (45%)
		leucine-rich repeat	450..473	CDD:275380	8/22 (36%)
		leucine-rich repeat	474..497	CDD:275380	4/22 (18%)
		leucine-rich repeat	498..518	CDD:275380	3/19 (16%)
		leucine-rich repeat	521..544	CDD:275380	3/22 (14%)
		leucine-rich repeat	545..566	CDD:275380	2/20 (10%)
		leucine-rich repeat	569..592	CDD:275380	4/22 (18%)
		leucine-rich repeat	593..615	CDD:275380	4/21 (19%)
		leucine-rich repeat	616..637	CDD:275380	5/23 (22%)
		leucine-rich repeat	638..662	CDD:275380	5/26 (19%)
		leucine-rich repeat	663..684	CDD:275380	4/20 (20%)
		leucine-rich repeat	685..708	CDD:275380	6/23 (26%)
		leucine-rich repeat	709..728	CDD:275380	3/18 (17%)
		LRR_8	883..943	CDD:290566	19/85 (22%)
		leucine-rich repeat	885..908	CDD:275380	6/48 (13%)
		leucine-rich repeat	909..932	CDD:275380	7/22 (32%)
		LRR_8	932..990	CDD:290566	16/60 (27%)
		leucine-rich repeat	933..956	CDD:275380	7/23 (30%)
		TIR	1114..1247	CDD:214587	40/141 (28%)
Tlr6	NP_997487.1	leucine-rich repeat	46..64	CDD:275380	5/26 (19%)
		leucine-rich repeat	65..88	CDD:275378	6/22 (27%)
		LRR_8	87..144	CDD:290566	24/61 (39%)
		leucine-rich repeat	89..112	CDD:275378	8/24 (33%)
		leucine-rich repeat	113..133	CDD:275378	10/22 (45%)
		leucine-rich repeat	134..158	CDD:275378	9/30 (30%)
		leucine-rich repeat	369..385	CDD:275380	3/39 (8%)
		LRR_RI	<380..>500	CDD:238064	29/132 (22%)
		LRR_8	388..451	CDD:290566	14/69 (20%)
		leucine-rich repeat	390..415	CDD:275380	7/28 (25%)
		leucine-rich repeat	416..440	CDD:275380	6/23 (26%)
		leucine-rich repeat	441..462	CDD:275380	0/20 (0%)
		LRR_8	461..516	CDD:290566	18/58 (31%)
		leucine-rich repeat	463..485	CDD:275380	7/22 (32%)
		leucine-rich repeat	486..508	CDD:275380	7/24 (29%)
		leucine-rich repeat	510..531	CDD:275380	6/20 (30%)
		LRRCT	540..594	CDD:214507	15/67 (22%)
		TIR	652..791	CDD:214587	40/139 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X221
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820