DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and Lrrtm3

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001099857.1 Gene:Lrrtm3 / 294380 RGDID:1304866 Length:582 Species:Rattus norvegicus


Alignment Length:633 Identity:137/633 - (21%)
Similarity:239/633 - (37%) Gaps:162/633 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   323 GLKNLQILNLSSNKIVALPTELF-----AE---------QAKIIQEVYLQNNSISVLNPQLFSNL 373
            |...:::|..|:..:|..||.|.     ||         :.|:   ||.::..:..:...:.:. 
  Rat     2 GFNVIRLLRGSAVAVVLAPTVLLTMLSSAERGCPKGCRCEGKM---VYCESQKLQEIPSSISAG- 62

  Fly   374 DQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLEN 438
                .|.||:...:...:..|.|.||.:|..|.|.||.::.::...|:.:..|:.|.|..|::..
  Rat    63 ----CLGLSLRYNSLQKLKYNQFKGLNQLTWLYLDHNHISNIDENAFNGIRRLKELILSSNRISY 123

  Fly   439 IAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNL 503
            ...:||.|:.||..|.||:|:|..|.:                        :.||....|..|:|
  Rat   124 FLNNTFRPVTNLRNLDLSYNQLHSLGS------------------------EQFRGLRKLLSLHL 164

  Fly   504 NGNQLKTVPLAL-RNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLP 567
            ..|.|:|:|:.: ::.|:|..:|||.|.|..:..:.|.|:..|..|.|..|....:.:..|..|.
  Rat   165 RSNSLRTIPVRIFQDCRNLELLDLGYNRIRSLARNVFAGMIRLKELHLEHNQFSKLNLALFPRLV 229

  Fly   568 NLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDING--LFSNMPSLLWLNISDNRL---- 626
            :||.|.:..|:|:|:........||:|.:.|.|||:...:|  :|..:|:|..||:..|:|    
  Rat   230 SLQNLYMQWNKISVIGQTMSWTWSSLQRLDLSGNEIEAFSGPSVFQCVPNLQRLNLDSNKLTFIG 294

  Fly   627 -ESFDYGHVPSTLQWLDLH-----------KNRLSSLSNRFGLDSELKLQT-LDVSFNQLQRIGP 678
             |..|        .|:.|:           ...:.||.|.......|:..| |..|..:||.:  
  Rat   295 QEILD--------SWISLNDISLAGNIWECSRNICSLVNWLKSFKGLRENTILCASPKELQGV-- 349

  Fly   679 SSIPNSIELLFLNDNLITTVDPDTFMHKTNLT-RVDLYANQITTLDIKSLRILPVWEHRALPEF- 741
                          |:|..|...:...|:..| |.|| |..:.....|..  ||..:|.:.|.. 
  Rat   350 --------------NVIDAVKNYSICGKSTTTERFDL-ARALPKPTFKPK--LPRPKHESKPPLP 397

  Fly   742 -YIGGNPFTCDCNIDW---------------------LQKINHITSRQYPRIMDLETIYCKLLNN 784
             .:|.:..:.:.::|.                     :..:.:::.::||..|........:..:
  Rat   398 PTVGASEPSPETDVDTEHISFHKIIAGSVALFLSVLVILLVMYVSWKRYPASMKQLQQRSLMRRH 462

  Fly   785 RERAYIPLIEAEP--KHFLCTYK----------THCFAVCHCCEFDACDCEMTCPTNCTCF--HD 835
            |::....|.:..|  :.|...||          .:....|...:..:.:||:....|.:.|  :|
  Rat   463 RKKKRQSLKQMTPGTQEFYVDYKPTNTETSEMLLNGTGPCTYSKSGSRECEIPLSMNVSTFLAYD 527

  Fly   836 Q----------------TWSTNIVECSGAAYSEMPRRVPMDTSELYID 867
            |                |:.||..|               ||.|.:::
  Rat   528 QPTISYCGVHHELLSHKTFETNAQE---------------DTMESHLE 560

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 40/158 (25%)
leucine-rich repeat 279..302 CDD:275380
LRR_8 301..386 CDD:290566 15/76 (20%)
leucine-rich repeat 303..326 CDD:275380 1/2 (50%)
leucine-rich repeat 327..350 CDD:275380 8/36 (22%)
LRR 350..729 CDD:227223 99/399 (25%)
leucine-rich repeat 352..375 CDD:275380 2/22 (9%)
leucine-rich repeat 376..401 CDD:275380 7/24 (29%)
LRR_RI <401..626 CDD:238064 65/227 (29%)
leucine-rich repeat 402..425 CDD:275380 6/22 (27%)
leucine-rich repeat 426..449 CDD:275380 7/22 (32%)
leucine-rich repeat 450..473 CDD:275380 7/22 (32%)
leucine-rich repeat 474..497 CDD:275380 2/22 (9%)
leucine-rich repeat 498..518 CDD:275380 7/20 (35%)
leucine-rich repeat 521..544 CDD:275380 8/22 (36%)
leucine-rich repeat 545..566 CDD:275380 5/20 (25%)
leucine-rich repeat 569..592 CDD:275380 6/22 (27%)
leucine-rich repeat 593..615 CDD:275380 7/23 (30%)
leucine-rich repeat 616..637 CDD:275380 7/25 (28%)
leucine-rich repeat 638..662 CDD:275380 5/34 (15%)
leucine-rich repeat 663..684 CDD:275380 5/21 (24%)
leucine-rich repeat 685..708 CDD:275380 4/22 (18%)
leucine-rich repeat 709..728 CDD:275380 6/19 (32%)
LRR_8 883..943 CDD:290566
leucine-rich repeat 885..908 CDD:275380
leucine-rich repeat 909..932 CDD:275380
LRR_8 932..990 CDD:290566
leucine-rich repeat 933..956 CDD:275380
TIR 1114..1247 CDD:214587
Lrrtm3NP_001099857.1 LRRNT 33..61 CDD:214470 3/30 (10%)
LRR 1 61..83 5/26 (19%)
leucine-rich repeat 66..86 CDD:275380 6/19 (32%)
LRR_RI <81..300 CDD:238064 71/250 (28%)
LRR 2 84..107 7/22 (32%)
LRR_8 86..145 CDD:290566 19/58 (33%)
leucine-rich repeat 87..110 CDD:275380 6/22 (27%)
LRR 3 109..131 6/21 (29%)
leucine-rich repeat 111..134 CDD:275380 7/22 (32%)
LRR 4 132..155 9/46 (20%)
LRR_8 133..193 CDD:290566 23/83 (28%)
leucine-rich repeat 135..158 CDD:275380 9/46 (20%)
LRR 5 156..179 7/22 (32%)
leucine-rich repeat 159..182 CDD:275380 7/22 (32%)
LRR_8 181..241 CDD:290566 19/59 (32%)
LRR 6 181..203 8/21 (38%)
leucine-rich repeat 183..206 CDD:275380 8/22 (36%)
LRR 7 205..227 5/21 (24%)
leucine-rich repeat 207..230 CDD:275380 6/22 (27%)
LRR 8 229..251 6/21 (29%)
LRR_8 230..290 CDD:290566 20/59 (34%)
leucine-rich repeat 231..254 CDD:275380 6/22 (27%)
LRR 9 252..276 9/23 (39%)
leucine-rich repeat 255..279 CDD:275380 7/23 (30%)
LRR 10 277..300 8/30 (27%)
leucine-rich repeat 280..300 CDD:275380 7/27 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 378..411 6/34 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

Return to query results.
Submit another query.