DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and Tlr5

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001139300.1 Gene:Tlr5 / 289337 RGDID:631351 Length:871 Species:Rattus norvegicus


Alignment Length:1063 Identity:246/1063 - (23%)
Similarity:398/1063 - (37%) Gaps:350/1063 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   331 NLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNP-------QLF--SNLDQL-------QAL 379
            :|.|::|:|...:|      :|..|::. :.:..::|       .||  .||.|:       :.|
  Rat     6 SLFSHRIMAYQLDL------LIGVVFMA-SPVLEMSPCFSDGRIALFRGCNLTQIPWVLNTTERL 63

  Fly   380 DLSMNQITSTWIDKNTFVGLIRLVLLNL--SHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAAD 442
            .||.|.|::  :...:|..|.:|:||.|  .:.:|| :..|.|.:|..|:||:|..:|:|.:..|
  Rat    64 LLSFNYIST--VVTTSFPLLEQLLLLELGTQYARLT-IGQEAFRNLPNLRILDLGQSQIEVLNPD 125

  Fly   443 TFAPMNNLHTLL-----LSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVH-PDAFRNCSALQDL 501
            .|..:.:|..|.     ||:..|:  |||..| |..|:.|.|..|.:..:| ..:|:..|:|.|:
  Rat   126 AFQGLPHLFELRLFDCGLSNAVLR--DAYFRN-LNSLARLDLSANEIHSLHLHSSFQELSSLSDI 187

  Fly   502 NLNGNQLKTV------PL----------------------------ALRNMRHLRTVDLGENMIT 532
            |.:.|::.|:      ||                            .||.:| |.|:||.||..|
  Rat   188 NFSFNRIFTLCEDELQPLQGRTLSFFGLKSTSLFSRVFVDWEACRNPLRGIR-LETLDLSENGWT 251

  Fly   533 ---------VMEDSAFKGLGNLYGLRLIGNYLENI---TMHTFRDLPNLQI--LNLARNRIAVVE 583
                     .::.|....|...|.:...|...:||   ...||..|....:  |:|:...|..:.
  Rat   252 AAILGNFSHTIQGSHISSLILTYHIMGSGFGFQNIKDPDQSTFASLARSSVLQLDLSHGYIFSLN 316

  Fly   584 PGAFEMTSSIQAVRLDGNELNDING-LFSNMPSLLWLNISDNRL----ESFDYGHVPSTLQWLDL 643
            |..||....::.:.|..|::|.|:. .|..:.||..||:|.|.|    .|..|| :|| :.:|||
  Rat   317 PRLFETLKDLKKLNLAFNKINKISDYAFHGLDSLQILNLSYNLLGELYNSNFYG-LPS-IAYLDL 379

  Fly   644 HKNRLSSLSNR-FGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKT 707
            .:|.:..:.:| |.|..  ||||||:..|.|:.||  .|| |::::.|..|.:           |
  Rat   380 QRNHIGIIQDRTFRLLK--KLQTLDLRDNALKTIG--FIP-SVQMVLLGSNKL-----------T 428

  Fly   708 NLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIM 772
            :|..|...||.| .|....|.                        |:..|..:..|...|:    
  Rat   429 HLPHVRFTANFI-ELSENGLE------------------------NLSDLYFLLRIPGLQF---- 464

  Fly   773 DLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQT 837
                    |:.|:.|                                                  
  Rat   465 --------LILNQNR-------------------------------------------------- 471

  Fly   838 WSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTT 902
                :..||...|:....   :...:|:: ..|.::||..:.|                  ....
  Rat   472 ----LSSCSNVDYAPSQN---LSLEQLFL-AENMLQLAWETGL------------------CWDI 510

  Fly   903 FSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRL 967
            |.||.||.||:|.:|::..|....|:.|..||.|.|.:|::..::.||  :...||:|.:..|:|
  Rat   511 FKGLSRLQILYLNNNYLNFLPPGIFNGLVALRMLSLSANRLTMLSPGS--LPANLEILDISRNQL 573

  Fly   968 MHFEVWQLSANPYLVE----ISLADNQWSCECGYLARFRNYLGQSSEKIIDA-SRVSC------- 1020
                   .|.:|.|..    :.:..|::.|:| .|:.|..:|.|::..:..: :.|.|       
  Rat   574 -------FSPDPGLFSSLRALDITHNEFICDC-ELSTFIVWLNQTNVTLFGSPADVYCMYPNSLL 630

  Fly  1021 ---IYNNATSVLREKNGTK---------CTLRDGVAHYMHTNEIEGLLPLLLVATCAFVAFFGLI 1073
               :||.:|....|:...:         ||:               .|.|.||.|.....|.|:.
  Rat   631 GSSLYNISTKDCDEEEAVRSLNFSLFILCTV---------------TLTLFLVITLIVTKFRGIC 680

  Fly  1074 FGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPN----DAYFAYSLQDEHFVNQILAQT 1134
            |  .|::...|:                .|..:.....|:    ||||.:|.:|..:....|.:.
  Rat   681 F--LCFKTIQKL----------------MFKGKFRNPEPSAYRYDAYFCFSSKDFEWAQNALLKH 727

  Fly  1135 LENDIGY------RLCLHYRDV--------NINAYITDALIEAAESAKQFVLVLSKNFLYNEWSR 1185
            |  |..|      |||...||.        ||.|        |...:::.|.::|::||.:.|..
  Rat   728 L--DAQYSSQNRLRLCFEERDFIPGENHISNIQA--------AVWGSRKTVCLVSRHFLKDGWCL 782

  Fly  1186 FEYKSALHELVKRRKRV-VFILYGDLPQRDIDMDMRH-----YLRTSTCIEW-----DDKKFWQK 1239
            ..::.|....:...||| :.::.|.|||..:   |||     :|:....:.|     |...|..|
  Rat   783 EAFRYAQSRCLSDLKRVLIVVVVGSLPQYQL---MRHETIRGFLQKQQYLRWPEDLQDVDWFLDK 844

  Fly  1240 LRLALPLPNGRGNNNKRVVSGCL 1262
            |                  |||:
  Rat   845 L------------------SGCI 849

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 45/159 (28%)
leucine-rich repeat 279..302 CDD:275380
LRR_8 301..386 CDD:290566 17/70 (24%)
leucine-rich repeat 303..326 CDD:275380
leucine-rich repeat 327..350 CDD:275380 5/18 (28%)
LRR 350..729 CDD:227223 128/456 (28%)
leucine-rich repeat 352..375 CDD:275380 7/31 (23%)
leucine-rich repeat 376..401 CDD:275380 7/31 (23%)
LRR_RI <401..626 CDD:238064 77/281 (27%)
leucine-rich repeat 402..425 CDD:275380 9/24 (38%)
leucine-rich repeat 426..449 CDD:275380 8/22 (36%)
leucine-rich repeat 450..473 CDD:275380 10/27 (37%)
leucine-rich repeat 474..497 CDD:275380 6/23 (26%)
leucine-rich repeat 498..518 CDD:275380 9/53 (17%)
leucine-rich repeat 521..544 CDD:275380 9/31 (29%)
leucine-rich repeat 545..566 CDD:275380 6/23 (26%)
leucine-rich repeat 569..592 CDD:275380 6/24 (25%)
leucine-rich repeat 593..615 CDD:275380 5/22 (23%)
leucine-rich repeat 616..637 CDD:275380 10/24 (42%)
leucine-rich repeat 638..662 CDD:275380 7/24 (29%)
leucine-rich repeat 663..684 CDD:275380 11/20 (55%)
leucine-rich repeat 685..708 CDD:275380 2/22 (9%)
leucine-rich repeat 709..728 CDD:275380 6/18 (33%)
LRR_8 883..943 CDD:290566 17/59 (29%)
leucine-rich repeat 885..908 CDD:275380 3/22 (14%)
leucine-rich repeat 909..932 CDD:275380 8/22 (36%)
LRR_8 932..990 CDD:290566 15/61 (25%)
leucine-rich repeat 933..956 CDD:275380 7/22 (32%)
TIR 1114..1247 CDD:214587 41/157 (26%)
Tlr5NP_001139300.1 LRR_8 <96..143 CDD:404697 15/47 (32%)
PLN00113 <108..>384 CDD:215061 78/281 (28%)
leucine-rich repeat 109..132 CDD:275380 8/22 (36%)
leucine-rich repeat 133..158 CDD:275380 10/27 (37%)
leucine-rich repeat 159..183 CDD:275380 6/23 (26%)
leucine-rich repeat 184..217 CDD:275380 7/32 (22%)
leucine-rich repeat 240..301 CDD:275380 16/60 (27%)
leucine-rich repeat 302..325 CDD:275380 6/22 (27%)
LRR 314..>578 CDD:227223 90/403 (22%)
LRR_8 326..384 CDD:404697 21/59 (36%)
leucine-rich repeat 326..349 CDD:275380 5/22 (23%)
leucine-rich repeat 350..373 CDD:275380 9/23 (39%)
leucine-rich repeat 374..397 CDD:275380 7/24 (29%)
leucine-rich repeat 398..432 CDD:275380 16/47 (34%)
leucine-rich repeat 433..461 CDD:275380 9/52 (17%)
leucine-rich repeat 462..487 CDD:275380 7/93 (8%)
leucine-rich repeat 488..516 CDD:275380 8/46 (17%)
leucine-rich repeat 517..540 CDD:275380 8/22 (36%)
leucine-rich repeat 541..559 CDD:275380 7/19 (37%)
leucine-rich repeat 563..586 CDD:275380 8/29 (28%)
PCC 567..>645 CDD:188093 17/85 (20%)
TIR 706..856 CDD:396246 44/175 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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