DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and Lgr4

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_775450.2	Gene:	Lgr4 / 286994	RGDID:	628615	Length:	951	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	130/478 - (27%)
Similarity:	212/478 - (44%)	Gaps:	105/478 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   264 SAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQ 328
            |.|..::.....|...:.||:|.|:...||.:.|.:...|..|.:..|.:|.|..|||||||.|:
  Rat    44 SGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKSFPFLEELQLAGNDLSFIHPKALSGLKELK 108

  Fly   329 ILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDK 393
            :|.|.:|::..:|:|                         ....|..||:|.|..|.|||  :.:
  Rat   109 VLTLQNNQLRTVPSE-------------------------AIHGLSALQSLRLDANHITS--VPE 146

  Fly   394 NTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHN 458
            ::|.||::|..|.|..|.||::.....|:|.|||.|.|..|.:.:|....|..:::|..|.|.:|
  Rat   147 DSFEGLVQLRHLWLDDNSLTEVPVRPLSNLPTLQALTLALNNISSIPDFAFTNLSSLVVLHLHNN 211

  Fly   459 KLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVP-LALRNMRHLR 522
            |:|.|..:..:||..|..|.|:.|.| ...|.|.:...:|::|..:.|.:..:| .|......||
  Rat   212 KIKSLSQHCFDGLDNLETLDLNYNNL-DEFPQAIKALPSLKELGFHSNSISVIPDGAFGGNPLLR 275

  Fly   523 TVDLGENMITVMEDSAFKGLGNLYGLRLIGN-------------YLENITM-------------- 560
            |:.|.:|.::.:.:|||..|.:|:.|.:.|.             :||::|:
  Rat   276 TIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASLVQWFPNLTGTVHLESLTLTGTKISSIPDDLCQ 340

  Fly   561 ------------HTFRDLPN------LQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDI- 606
                        :..||||:      |:.::|.||:|::::...|:..:|::.:.|..|.:.:|
  Rat   341 NQKMLRTLDLSYNNIRDLPSFNGCRALEEISLQRNQISLIKENTFQGLTSLRILDLSRNLIREIH 405

  Fly   607 NGLFSNMPSLLWLNISDNRLESFDYGHVPST----LQWLDLHKN-------------RLSSLSNR 654
            :|.|:.:.::..|::|.|.|.||     |:.    |..|.|..|             .|.|||..
  Rat   406 SGAFAKLGTITNLDVSFNELTSF-----PTEGLNGLNQLKLVGNFKLKDALAARDFANLRSLSVP 465

  Fly   655 F--------GLDSELKLQTLDVS 669
            :        |.||...|.|.|.|
  Rat   466 YAYQCCAFWGCDSYANLNTEDNS 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	3/13 (23%)
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	60/189 (32%)
		leucine-rich repeat	279..302	CDD:275380	7/22 (32%)
		LRR_8	301..386	CDD:290566	24/84 (29%)
		leucine-rich repeat	303..326	CDD:275380	11/22 (50%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		LRR	350..729	CDD:227223	102/392 (26%)
		leucine-rich repeat	352..375	CDD:275380	1/22 (5%)
		leucine-rich repeat	376..401	CDD:275380	11/24 (46%)
		LRR_RI	<401..626	CDD:238064	71/271 (26%)
		leucine-rich repeat	402..425	CDD:275380	8/22 (36%)
		leucine-rich repeat	426..449	CDD:275380	7/22 (32%)
		leucine-rich repeat	450..473	CDD:275380	9/22 (41%)
		leucine-rich repeat	474..497	CDD:275380	7/22 (32%)
		leucine-rich repeat	498..518	CDD:275380	5/20 (25%)
		leucine-rich repeat	521..544	CDD:275380	9/22 (41%)
		leucine-rich repeat	545..566	CDD:275380	7/59 (12%)
		leucine-rich repeat	569..592	CDD:275380	6/22 (27%)
		leucine-rich repeat	593..615	CDD:275380	5/22 (23%)
		leucine-rich repeat	616..637	CDD:275380	7/20 (35%)
		leucine-rich repeat	638..662	CDD:275380	11/44 (25%)
		leucine-rich repeat	663..684	CDD:275380	4/7 (57%)
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
Lgr4	NP_775450.2	LRRNT	29..61	CDD:214470	3/16 (19%)
		LRR 1	58..79		7/20 (35%)
		leucine-rich repeat	59..82	CDD:275380	7/22 (32%)
		LRR	<62..301	CDD:227223	84/266 (32%)
		LRR 2	82..103		8/20 (40%)
		leucine-rich repeat	83..106	CDD:275380	11/22 (50%)
		LRR 3	106..127		6/45 (13%)
		leucine-rich repeat	107..130	CDD:275380	7/47 (15%)
		LRR 4	130..151		9/22 (41%)
		leucine-rich repeat	131..154	CDD:275380	11/24 (46%)
		LRR 5	154..177		7/22 (32%)
		leucine-rich repeat	155..178	CDD:275380	8/22 (36%)
		LRR 6	178..199		8/20 (40%)
		leucine-rich repeat	179..202	CDD:275380	7/22 (32%)
		LRR 7	202..223		7/20 (35%)
		leucine-rich repeat	203..226	CDD:275380	9/22 (41%)
		LRR 8	226..247		7/21 (33%)
		leucine-rich repeat	227..249	CDD:275380	7/22 (32%)
		LRR 9	249..270		5/20 (25%)
		leucine-rich repeat	250..273	CDD:275380	5/22 (23%)
		LRR 10	273..294		8/20 (40%)
		leucine-rich repeat	274..295	CDD:275380	8/20 (40%)
		LRR	275..>465	CDD:227223	45/194 (23%)
		LRR 11	320..341		3/20 (15%)
		leucine-rich repeat	321..344	CDD:275378	3/22 (14%)
		LRR 12	344..365		4/20 (20%)
		LRR_8	345..401	CDD:404697	13/55 (24%)
		leucine-rich repeat	345..366	CDD:275378	4/20 (20%)
		LRR 13	366..387		6/20 (30%)
		leucine-rich repeat	367..390	CDD:275378	6/22 (27%)
		LRR 14	390..411		6/20 (30%)
		leucine-rich repeat	391..414	CDD:275378	5/22 (23%)
		LRR 15	414..435		7/25 (28%)
		leucine-rich repeat	415..427	CDD:275378	4/11 (36%)
		leucine-rich repeat	436..461	CDD:275380	5/24 (21%)
		7tmA_LGR4	539..812	CDD:320483
		TM helix 1	541..565	CDD:320483
		TM helix 2	574..595	CDD:320483
		TM helix 3	619..641	CDD:320483
		TM helix 4	664..680	CDD:320483
		TM helix 5	704..727	CDD:320483
		TM helix 6	746..768	CDD:320483
		TM helix 7	780..805	CDD:320483
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45836
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010