DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and Lgi1

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_665712.1	Gene:	Lgi1 / 252892	RGDID:	628742	Length:	557	Species:	Rattus norvegicus

Alignment Length:	636	Identity:	130/636 - (20%)
Similarity:	225/636 - (35%)	Gaps:	161/636 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   772 MDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQ 836
            |:.|:|  :.:.|   |.|||  ....:|||     .|:|....| .....:..||..|||..|.
  Rat     1 MESESI--RRMGN---ACIPL--KRIAYFLC-----LFSVVLLTE-GKKPAKPKCPAVCTCSKDN 52

  Fly   837 TWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNT 901
            ..      |..|  ..:||.||.|...|....:.|.|::..|||...:|.:|...:::...|.:.
  Rat    53 AL------CENA--RSIPRTVPPDVISLSFVRSGFTEISEGSFLFTPSLQLLLFTSNSFDVISDD 109

  Fly   902 TFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGN- 965
            .|.||..|..|.:|:|:|.|:..:.|..|::|..|.|.:|.:.::....|:.|..|..:.|.||
  Rat   110 AFIGLPHLEYLFIENNNIKSISRHTFRGLKSLIHLSLANNNLQTLPKDIFKGLDSLTNVDLRGNS 174

  Fly   966 -----RLMHFEVWQLSANPYLVEI--------------SLADNQWSCECGYLARFR--------- 1002
                 :|.....|....|..:.:|              ||:...:.|.....|:.:
  Rat   175 FNCDCKLKWLVEWLGHTNATVEDIYCEGPPEYKKRKINSLSPKDFDCIITEFAKSQDLPYQSLSI 239

  Fly  1003 ---NYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLPL----LL 1060
               :||......|.......||:.....|  ||.            :.:.:.|.|...:    ::
  Rat   240 DTFSYLNDEYVVIAQPFTGKCIFLEWDHV--EKT------------FRNYDNITGTSTVVCKPIV 290

  Fly  1061 VATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRF--VDQLDKERPNDAYFAYSLQD 1123
            :.|..:|....|..|...|:.:            .|..|..:.  ::.|...:|||.. .:.::|
  Rat   291 IDTQLYVIVAQLFGGSHIYKRD------------GFANKFIKIQDIEVLKIRKPNDIE-TFKIED 342

  Fly  1124 EHFVNQILAQTLE---------NDIGYRLCLHYRDVNINAYITDALIEAAESAKQFV------LV 1173
            ..:.  ::|.:.:         |..|:     |...:::|:..|..:|..|.|:..:      |:
  Rat   343 NWYF--VVADSSKAGFTTIYKWNGNGF-----YSHQSLHAWYRDTDVEYLEIARPPLTLRTPHLI 400

  Fly  1174 LSKN----FLYNEWSRFEYKSALHELVKRRKRVVFILYGDLP-------------QRDIDMDMRH 1221
            ||.:    .:| :||              :...:||...|:|             :.|:.:.:..
  Rat   401 LSSSSQRPVIY-QWS--------------KATQLFINQTDIPNMEDVYAVKHFSVKGDVYICLTR 450

  Fly  1222 YLRTSTCIEWDDKKFWQKLRLALPLPNGRG---------NNNKRVVSGCLSGRTPSVNMYATSH- 1276
            ::..|..::|....|....|:.     .||         ||.:..:.|.....|...|..|...
  Rat   451 FIGDSKVMKWGGSSFQDIQRMP-----SRGSMVFQPLQINNYQYAILGSDYSFTQVYNWDAEKAK 510

  Fly  1277 --EYQAGNGGVIPPPSARYADCGSNNYATINECAAAGGGRGYKPIPTSASA 1325
              ::|..|  |..|.|..:......|:  :...:..|..:.||.:....||
  Rat   511 FVKFQELN--VQAPRSFTHVSINKRNF--LFASSFKGNTQIYKHVIVDLSA 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR	350..729	CDD:227223
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		LRR_RI	<401..626	CDD:238064
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	426..449	CDD:275380
		leucine-rich repeat	450..473	CDD:275380
		leucine-rich repeat	474..497	CDD:275380
		leucine-rich repeat	498..518	CDD:275380
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..566	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		leucine-rich repeat	593..615	CDD:275380
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566	18/59 (31%)
		leucine-rich repeat	885..908	CDD:275380	6/22 (27%)
		leucine-rich repeat	909..932	CDD:275380	8/22 (36%)
		LRR_8	932..990	CDD:290566	16/77 (21%)
		leucine-rich repeat	933..956	CDD:275380	6/22 (27%)
		TIR	1114..1247	CDD:214587	26/164 (16%)
Lgi1	NP_665712.1	leucine-rich repeat	71..92	CDD:275378	6/20 (30%)
		LRR_8	91..151	CDD:404697	18/59 (31%)
		LRR 1	92..113		4/20 (20%)
		leucine-rich repeat	93..116	CDD:275378	6/22 (27%)
		LRR 2	116..137		7/20 (35%)
		leucine-rich repeat	117..140	CDD:275378	8/22 (36%)
		LRR 3	140..161		5/20 (25%)
		leucine-rich repeat	141..164	CDD:275378	6/22 (27%)
		PCC	146..>221	CDD:188093	14/74 (19%)
		leucine-rich repeat	165..177	CDD:275378	4/11 (36%)
		EAR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	225..267		6/41 (15%)
		EPTP	225..264	CDD:397689	6/38 (16%)
		EAR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	271..313		7/65 (11%)
		EPTP	272..310	CDD:397689	6/37 (16%)
		EAR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	317..364		7/49 (14%)
		EPTP	317..361	CDD:397689	7/46 (15%)
		EAR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	366..415		13/68 (19%)
		EAR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	419..462		7/42 (17%)
		EPTP	420..459	CDD:397689	6/38 (16%)
		EAR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	464..506		9/46 (20%)
		EPTP	464..502	CDD:397689	8/42 (19%)
		EAR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	510..552		9/45 (20%)
		EPTP	510..549	CDD:397689	7/42 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000