DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and Lgi2

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_659194.1 Gene:Lgi2 / 246316 MGIID:2180196 Length:550 Species:Mus musculus


Alignment Length:520 Identity:105/520 - (20%)
Similarity:178/520 - (34%) Gaps:203/520 - (39%)


- Green bases have known domain annotations that are detailed below.


  Fly   826 CPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYA 890
            ||..|:|..:.      :.|.|:::  :||.||.|.|.|.:....|:|:....|....:|.:|..
Mouse    33 CPATCSCTKES------IICVGSSW--VPRIVPGDISSLSLVNGTFLEIKDRMFSHLPSLQLLLL 89

  Fly   891 NNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLR 955
            |:::...|.:..|:||                    ||    |..|:::.|||.:|:..:|:.||
Mouse    90 NSNSFTVIRDDAFAGL--------------------FH----LEYLFIEGNKIETISRNAFRGLR 130

  Fly   956 KLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCECG----YLARFRNYLGQSSEKIIDAS 1016
            .|..|.|.||:   ||                     |:|.    ||     :|..::..:.|  
Mouse   131 DLTHLDLRGNK---FE---------------------CDCKAKWLYL-----WLKMTNSTVSD-- 164

  Fly  1017 RVSCI---------YNNATSVLREKNGTKCTLRDGVAHYMHTNEIE--GLLPLLLVATCAFVAFF 1070
             |.||         .|..||...|     ||...     ..|:|.:  |....|.:..|..:   
Mouse   165 -VLCIGPPEYQEKKLNEVTSFDYE-----CTTTG-----PQTDEAKQRGWQLELSLGFCELI--- 215

  Fly  1071 GLIFGLFCYRHELKIW-AHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYS-------------- 1120
                  |.::|.|..: .|.|     ..|:|.. ||..:.:  ||.|.|.:              
Mouse   216 ------FVFQHPLSDFVVHQT-----LPYQSVS-VDTFNSK--NDVYVAIAQPSMENCMVLEWDH 266

  Fly  1121 -----------------------LQDEHFVNQILAQTL------ENDIGYRLCLHYRDVNINAYI 1156
                                   :.|:.||  ::||..      :.|..:...:.::|:.::...
Mouse   267 IEMNFRSYDNITGQSIVGCKAILIDDQVFV--VVAQLFGGSHIYKYDESWTKFVKFQDIEVSRIS 329

  Fly  1157 TDALIEAAESAKQ--FVLV------LSKNFLYNEWSRFEYKSALHE------------------L 1195
            ....||..|...:  |::.      ||..:.:|....:.|:| |||                  :
Mouse   330 KPNDIELFEIDDETFFIIADSSKAGLSTVYKWNSKGFYSYQS-LHEWFRDTDAEFVDIDGKSHLI 393

  Fly  1196 VKRRKRVVFIL-----------YGDLP-------------QRDIDMDMRHYLRTSTCIEWDDKKF 1236
            :..|.:|..||           :||:|             |..:.:.:..::..|..:.|:.|:|
Mouse   394 LSSRSQVPIILQWNKSSKKFVPHGDIPNMEDVLAVKSFRMQNTLYLSLTRFIGDSRVMRWNSKQF 458

  Fly  1237  1236
            Mouse   459  458

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064
leucine-rich repeat 279..302 CDD:275380
LRR_8 301..386 CDD:290566
leucine-rich repeat 303..326 CDD:275380
leucine-rich repeat 327..350 CDD:275380
LRR 350..729 CDD:227223
leucine-rich repeat 352..375 CDD:275380
leucine-rich repeat 376..401 CDD:275380
LRR_RI <401..626 CDD:238064
leucine-rich repeat 402..425 CDD:275380
leucine-rich repeat 426..449 CDD:275380
leucine-rich repeat 450..473 CDD:275380
leucine-rich repeat 474..497 CDD:275380
leucine-rich repeat 498..518 CDD:275380
leucine-rich repeat 521..544 CDD:275380
leucine-rich repeat 545..566 CDD:275380
leucine-rich repeat 569..592 CDD:275380
leucine-rich repeat 593..615 CDD:275380
leucine-rich repeat 616..637 CDD:275380
leucine-rich repeat 638..662 CDD:275380
leucine-rich repeat 663..684 CDD:275380
leucine-rich repeat 685..708 CDD:275380
leucine-rich repeat 709..728 CDD:275380
LRR_8 883..943 CDD:290566 12/59 (20%)
leucine-rich repeat 885..908 CDD:275380 7/22 (32%)
leucine-rich repeat 909..932 CDD:275380 2/22 (9%)
LRR_8 932..990 CDD:290566 16/57 (28%)
leucine-rich repeat 933..956 CDD:275380 8/22 (36%)
TIR 1114..1247 CDD:214587 34/216 (16%)
Lgi2NP_659194.1 leucine-rich repeat 63..83 CDD:275380 4/19 (21%)
LRR_8 94..142 CDD:290566 20/74 (27%)
LRR_4 107..143 CDD:289563 15/42 (36%)
leucine-rich repeat 108..131 CDD:275378 8/22 (36%)
TPKR_C2 140..>174 CDD:301599 12/65 (18%)
EPTP 224..265 CDD:281697 10/48 (21%)
EPTP 271..311 CDD:281697 5/41 (12%)
EPTP 316..362 CDD:281697 7/45 (16%)
EPTP 365..407 CDD:281697 9/42 (21%)
EPTP 412..454 CDD:281697 5/41 (12%)
EPTP 457..498 CDD:281697 1/2 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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