Protein Alignment Toll-6 and Tsku

DIOPT Version :10

• Sequence 1: NP_524081.1
• Gene: Toll-6 / 39663
• FlyBaseID: FBgn0036494
• Length: 1514
• Species: Drosophila melanogaster
• Sequence 2: NP_001019790.1
• Gene: Tsku / 244152
• MGIID: 2443855
• Length: 354
• Species: Mus musculus
• Alignment Length: 262
• Identity: 76/262 - (29%)
• Similarity: 132/262 - (50%)
• Gaps: 27/262 - (10%)

  Fly   379 LDLSMNQITSTWIDKNTFV--GLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAA 441
            ||||.|::.:  ::::...  |...|..|:||:|.||.:.|..||.|..|:.|:|.||.|..:.|
Mouse    64 LDLSSNRLET--VNESVLAGPGYTTLAGLDLSYNLLTSIMPSAFSRLRYLESLDLSHNGLAALPA 126

  Fly   442 DTF--APMNNLHTLLLSHNKLKYLDAYAL------NGLYVLSLLSLDNNALIGVHPDAFR---NC 495
            :.|  :|:::::   ||||:|:.:...|.      ..|:|    .|.:|.:..:.|...|   ..
Mouse   127 EIFTSSPLSDIN---LSHNRLREVSISAFTTHSQGRALHV----DLSHNLIHRLLPHPARASLPA 184

  Fly   496 SALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIG-NYLENIT 559
            ..:|.|||:.|:.:.|| .||:: .||.:.|..|.:..:...||.||..|..|.|.. ..:.::.
Mouse   185 PTIQSLNLSWNRFRAVP-DLRDL-PLRYLSLDGNPLATINPDAFMGLAGLTHLSLASLQGILHLP 247

  Fly   560 MHTFRDLPNLQILNLARN-RIAVVEPGAFEMTSSIQAVRLDGNELNDI-NGLFSNMPSLLWLNIS 622
            .|.||:||.||:|:|:.| ::.......|.....:|.:.|.|:.|..: ..|..::|:|..:::.
Mouse   248 PHGFRELPGLQVLDLSGNPKLKWAGAEVFSGLGLLQELDLSGSSLVPLPEMLLHHLPALQSVSVG 312

  Fly   623 DN 624
            .:
Mouse   313 QD 314

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_524081.1	PPP1R42	<135..>242	CDD:455733
		leucine-rich repeat	148..171	CDD:275380
		leucine-rich repeat	172..201	CDD:275380
		LRR_8	200..>246	CDD:404697
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		leucine-rich repeat	279..302	CDD:275380
		LRR	299..654	CDD:443914	76/262 (29%)
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380	6/23 (26%)
		leucine-rich repeat	402..425	CDD:275380	11/22 (50%)
		leucine-rich repeat	426..449	CDD:275380	9/24 (38%)
		leucine-rich repeat	450..473	CDD:275380	7/28 (25%)
		leucine-rich repeat	474..497	CDD:275380	4/25 (16%)
		leucine-rich repeat	498..518	CDD:275380	9/19 (47%)
		leucine-rich repeat	521..544	CDD:275380	8/22 (36%)
		leucine-rich repeat	545..566	CDD:275380	6/21 (29%)
		leucine-rich repeat	569..592	CDD:275380	6/23 (26%)
		leucine-rich repeat	593..615	CDD:275380	5/22 (23%)
		leucine-rich repeat	616..637	CDD:275380	1/9 (11%)
		leucine-rich repeat	638..662	CDD:275380
		LRR_8	662..719	CDD:404697
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR	<863..>990	CDD:443914
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
Tsku	NP_001019790.1	LRR 1	60..81		5/18 (28%)
		leucine-rich repeat	63..86	CDD:275380	6/23 (26%)
		LRR	<85..>300	CDD:443914	67/223 (30%)
		LRR 2	86..107		9/20 (45%)
		leucine-rich repeat	87..110	CDD:275380	11/22 (50%)
		LRR 3	110..131		8/20 (40%)
		leucine-rich repeat	111..132	CDD:275380	8/20 (40%)
		LRR 4	133..154		7/23 (30%)
		leucine-rich repeat	134..186	CDD:275380	12/58 (21%)
		leucine-rich repeat	158..182	CDD:275380	6/27 (22%)
		LRR 5	160..180		5/23 (22%)
		LRR 6	186..207		9/22 (41%)
		leucine-rich repeat	187..205	CDD:275380	8/18 (44%)
		leucine-rich repeat	208..231	CDD:275380	8/22 (36%)
		LRR 7	208..228		6/19 (32%)
		LRR 8	231..253		5/21 (24%)
		leucine-rich repeat	232..256	CDD:275380	7/23 (30%)
		LRR 9	256..277		5/20 (25%)
		leucine-rich repeat	257..281	CDD:275380	6/23 (26%)
		LRR 10	281..302		5/20 (25%)
		leucine-rich repeat	282..305	CDD:275380	5/22 (23%)