DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and Tlr2

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:XP_006501523.1 Gene:Tlr2 / 24088 MGIID:1346060 Length:794 Species:Mus musculus


Alignment Length:980 Identity:210/980 - (21%)
Similarity:372/980 - (37%) Gaps:280/980 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   337 IVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQ-----LQALDLSMNQITSTWIDKNTF 396
            :||: |.||:::....:.:....:.:.....:.|:::..     :::||||.|:|  |:|.....
Mouse    21 LVAI-TVLFSKRCSAQESLSCDASGVCDGRSRSFTSIPSGLTAAMKSLDLSFNKI--TYIGHGDL 82

  Fly   397 VGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLK 461
            .....|.:|.|..:::..:|.:.|..|.:|:.|:|..|.|.::::..|.|:::          ||
Mouse    83 RACANLQVLMLKSSRINTIEGDAFYSLGSLEHLDLSDNHLSSLSSSWFGPLSS----------LK 137

  Fly   462 YLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDL 526
            ||:... |....|.:.||            |.|.:.||.|.: ||        :.....:|.:| 
Mouse   138 YLNLMG-NPYQTLGVTSL------------FPNLTNLQTLRI-GN--------VETFSEIRRID- 179

  Fly   527 GENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTS 591
                        |.||.:|..|.:....|.|....:.:.:.::..|.|..:..|.:    .|:.:
Mouse   180 ------------FAGLTSLNELEIKALSLRNYQSQSLKSIRDIHHLTLHLSESAFL----LEIFA 228

  Fly   592 SIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFG 656
            .|                   :.|:.:|.:.|..|..|.:..:|     :|...:.:..|:.|..
Mouse   229 DI-------------------LSSVRYLELRDTNLARFQFSPLP-----VDEVSSPMKKLAFRGS 269

  Fly   657 LDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTF--MHKTNLTRVDLYA--N 717
            :       ..|.|||:|.::          |.::.:......|..|.  :...|.:..|:.:  .
Mouse   270 V-------LTDESFNELLKL----------LRYILELSEVEFDDCTLNGLGDFNPSESDVVSELG 317

  Fly   718 QITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETIYCKLL 782
            ::.|:.|:.|.|         |:||:                           ..||.|:| .||
Mouse   318 KVETVTIRRLHI---------PQFYL---------------------------FYDLSTVY-SLL 345

  Fly   783 NNRERAYIPLIEAEPKHFL--CTYKTHCFAVCHCCEF-DACDCEMTCPTNCTCFHDQTWSTNIVE 844
            ...:|..:    ...|.||  |::..|..::    || |..:..|.          :.:..|.. 
Mouse   346 EKVKRITV----ENSKVFLVPCSFSQHLKSL----EFLDLSENLMV----------EEYLKNSA- 391

  Fly   845 CSGAAYSEMPRRVPMDTSELYIDGNNF--VELAGHSFLGRKNLAVLYANNSNVAH---------- 897
            |.||..|         ...|.:..|:.  ::..|...|..|||..|..:. |..|          
Mouse   392 CKGAWPS---------LQTLVLSQNHLRSMQKTGEILLTLKNLTSLDISR-NTFHPMPDSCQWPE 446

  Fly   898 ---IYNTTFSGLK--------RLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSF 951
               ..|.:.:|::        .|.:|.:.:|::.|.  :.|  |..|:|||:..||:.::.:.| 
Mouse   447 KMRFLNLSSTGIRVVKTCIPQTLEVLDVSNNNLDSF--SLF--LPRLQELYISRNKLKTLPDAS- 506

  Fly   952 QMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFR-------------- 1002
             :...|.|:::..|.:..|...||.:.|.|..:...||.:.|.|..|: |.              
Mouse   507 -LFPVLLVMKIRENAVSTFSKDQLGSFPKLETLEAGDNHFVCSCELLS-FTMETPALAQILVDWP 569

  Fly  1003 -NYLGQSSEKI----IDASRVSCIYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLPLLLVA 1062
             :||..|..::    :..:|.|.:..:..:::   :|..|.|.              ||.||:.|
Mouse   570 DSYLCDSPPRLHGHRLQDARPSVLECHQAALV---SGVCCALL--------------LLILLVGA 617

  Fly  1063 TCAFVAFFGLIFGLFCYRHELKIWAHSTN------CLMNFCYKSPRFVDQLDKERPNDAYFAYSL 1121
            .|..  |.||     .|...:..|..:..      | .:.||               ||:.:||.
Mouse   618 LCHH--FHGL-----WYLRMMWAWLQAKRKPKKAPC-RDVCY---------------DAFVSYSE 659

  Fly  1122 QDEHFVNQILAQTLEN-DIGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSR 1185
            ||.|:|..::.|.||| |..::||||.||.....:|.|.:|::.|.:.:.|.|||:||:.:||.:
Mouse   660 QDSHWVENLMVQQLENSDPPFKLCLHKRDFVPGKWIIDNIIDSIEKSHKTVFVLSENFVRSEWCK 724

  Fly  1186 FEYKSALHELVKRRKRVVFILYGD------LPQRDIDMDMRHYLRTSTCIEW-----DDKKFWQK 1239
            :|...:...|.........::..:      :|||  ...:|..:.|.|.:||     ..:.||..
Mouse   725 YELDFSHFRLFDENNDAAILVLLEPIERKAIPQR--FCKLRKIMNTKTYLEWPLDEGQQEVFWVN 787

  Fly  1240 LRLAL 1244
            ||.|:
Mouse   788 LRTAI 792

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 31/135 (23%)
leucine-rich repeat 279..302 CDD:275380
LRR_8 301..386 CDD:290566 11/53 (21%)
leucine-rich repeat 303..326 CDD:275380
leucine-rich repeat 327..350 CDD:275380 5/12 (42%)
LRR 350..729 CDD:227223 73/387 (19%)
leucine-rich repeat 352..375 CDD:275380 1/22 (5%)
leucine-rich repeat 376..401 CDD:275380 8/24 (33%)
LRR_RI <401..626 CDD:238064 45/224 (20%)
leucine-rich repeat 402..425 CDD:275380 6/22 (27%)
leucine-rich repeat 426..449 CDD:275380 7/22 (32%)
leucine-rich repeat 450..473 CDD:275380 5/22 (23%)
leucine-rich repeat 474..497 CDD:275380 5/22 (23%)
leucine-rich repeat 498..518 CDD:275380 5/19 (26%)
leucine-rich repeat 521..544 CDD:275380 5/22 (23%)
leucine-rich repeat 545..566 CDD:275380 4/20 (20%)
leucine-rich repeat 569..592 CDD:275380 4/22 (18%)
leucine-rich repeat 593..615 CDD:275380 1/21 (5%)
leucine-rich repeat 616..637 CDD:275380 5/20 (25%)
leucine-rich repeat 638..662 CDD:275380 3/23 (13%)
leucine-rich repeat 663..684 CDD:275380 5/20 (25%)
leucine-rich repeat 685..708 CDD:275380 3/24 (13%)
leucine-rich repeat 709..728 CDD:275380 3/20 (15%)
LRR_8 883..943 CDD:290566 19/80 (24%)
leucine-rich repeat 885..908 CDD:275380 6/43 (14%)
leucine-rich repeat 909..932 CDD:275380 6/22 (27%)
LRR_8 932..990 CDD:290566 16/57 (28%)
leucine-rich repeat 933..956 CDD:275380 7/22 (32%)
TIR 1114..1247 CDD:214587 46/143 (32%)
Tlr2XP_006501523.1 internalin_A <58..>259 CDD:380193 57/275 (21%)
leucine-rich repeat 65..87 CDD:275378 8/23 (35%)
LRR_8 87..145 CDD:338972 17/68 (25%)
leucine-rich repeat 88..111 CDD:275378 6/22 (27%)
leucine-rich repeat 112..135 CDD:275378 7/22 (32%)
leucine-rich repeat 136..160 CDD:275378 10/36 (28%)
leucine-rich repeat 186..212 CDD:275380 4/25 (16%)
leucine-rich repeat 213..233 CDD:275380 5/42 (12%)
PRK15370 <350..>568 CDD:185268 54/253 (21%)
leucine-rich repeat 372..398 CDD:275380 8/40 (20%)
leucine-rich repeat 399..424 CDD:275380 4/24 (17%)
leucine-rich repeat 448..468 CDD:275380 2/19 (11%)
leucine-rich repeat 469..488 CDD:275380 6/22 (27%)
leucine-rich repeat 489..510 CDD:275380 7/22 (32%)
leucine-rich repeat 511..534 CDD:275380 6/22 (27%)
TPKR_C2 543..596 CDD:387596 10/53 (19%)
TIR 650..794 CDD:214587 48/160 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X221
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.820

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