DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-6 and Rtn4rl1

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	XP_006533288.1	Gene:	Rtn4rl1 / 237847	MGIID:	2661375	Length:	498	Species:	Mus musculus

Alignment Length:	355	Identity:	89/355 - (25%)
Similarity:	133/355 - (37%)	Gaps:	86/355 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   330 LNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKN 394
            ::..::...|:| |...|.:   :.::||||.|:.|....||  ..:..|.:..|.|  |:|..|
Mouse    91 VSCQAHNFAAIP-EGIPEDS---ERIFLQNNRITFLQQGHFS--PAMVTLWIYSNNI--TFIAPN 147

  Fly   395 TFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNK 459
            ||.|.:.|..|:|..|:                       ||..:|.:||..:..||.|.|....
Mouse   148 TFEGFVHLEELDLGDNR-----------------------QLRTLAPETFQGLVKLHALYLYKCG 189

  Fly   460 LKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTV 524
            |..|.|....||:.|..|.|.:|.:..:..|.|.:...|..|.|:||:|.:
Mouse   190 LSALPAGIFGGLHSLQYLYLQDNHIEYLQDDIFVDLVNLSHLFLHGNKLWS-------------- 240

  Fly   525 DLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEM 589
             ||:.:        |:||.||..|.|..|.|:.:....|.||..|..|.|..|.:..::......
Mouse   241 -LGQGI--------FRGLVNLDRLLLHENQLQWVHHKAFHDLHRLTTLFLFNNSLTELQGDCLAP 296

  Fly   590 TSSIQAVRLDGNE-------------LNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWL 641
            ..:::.:||:||.             |....|..|.:|..                 .|...|..
Mouse   297 LVALEFLRLNGNAWDCGCRARSLWEWLRRFRGSSSAVPCA-----------------TPELRQGQ 344

  Fly   642 DLHKNRLSSLSNRFGLDS--ELKLQTLDVS 669
            ||...|:....|..|..|  ::|..||..|
Mouse   345 DLKLLRVEDFRNCTGPVSPHQIKSHTLTTS 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	37/137 (27%)
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566	14/55 (25%)
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380	4/19 (21%)
		LRR	350..729	CDD:227223	85/335 (25%)
		leucine-rich repeat	352..375	CDD:275380	8/22 (36%)
		leucine-rich repeat	376..401	CDD:275380	9/24 (38%)
		LRR_RI	<401..626	CDD:238064	56/237 (24%)
		leucine-rich repeat	402..425	CDD:275380	4/22 (18%)
		leucine-rich repeat	426..449	CDD:275380	5/22 (23%)
		leucine-rich repeat	450..473	CDD:275380	9/22 (41%)
		leucine-rich repeat	474..497	CDD:275380	6/22 (27%)
		leucine-rich repeat	498..518	CDD:275380	6/19 (32%)
		leucine-rich repeat	521..544	CDD:275380	5/22 (23%)
		leucine-rich repeat	545..566	CDD:275380	6/20 (30%)
		leucine-rich repeat	569..592	CDD:275380	4/22 (18%)
		leucine-rich repeat	593..615	CDD:275380	7/34 (21%)
		leucine-rich repeat	616..637	CDD:275380	1/20 (5%)
		leucine-rich repeat	638..662	CDD:275380	7/25 (28%)
		leucine-rich repeat	663..684	CDD:275380	3/7 (43%)
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
Rtn4rl1	XP_006533288.1	leucine-rich repeat	90..111	CDD:275380	4/23 (17%)
		LRR	<108..>308	CDD:227223	67/252 (27%)
		leucine-rich repeat	131..154	CDD:275380	9/24 (38%)
		leucine-rich repeat	155..179	CDD:275380	9/46 (20%)
		leucine-rich repeat	180..203	CDD:275380	9/22 (41%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		LRR_8	227..286	CDD:338972	24/81 (30%)
		leucine-rich repeat	228..251	CDD:275380	11/45 (24%)
		leucine-rich repeat	252..275	CDD:275380	8/22 (36%)
		leucine-rich repeat	276..299	CDD:275380	4/22 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45836
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100