DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and FBXL13

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001381423.1 Gene:FBXL13 / 222235 HGNCID:21658 Length:825 Species:Homo sapiens


Alignment Length:810 Identity:162/810 - (20%)
Similarity:272/810 - (33%) Gaps:280/810 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    92 PEIAL-TCNLRT---VNSEFDT------TNFSVIPAEHTIALHILCNDEIMAKSRLEAQSFAHLV 146
            ||:.: .|:..|   |.:.|.|      ||.:|:.|| .:...:.|.:     .||:...|.|..
Human    93 PELMIKACSFYTGHLVKTHFCTWRDIARTNENVVLAE-KMNRAVTCYN-----FRLQKSVFHHWH 151

  Fly   147 RLQQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNN 211
            ...:                |..|:|:|:.||...|::          ...:|..|.:...::.:
Human   152 SYME----------------DQKEKLKNILLRIQQIIY----------CHKLTIILTKWRNTARH 190

  Fly   212 IWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCS 276
            .....::......||. |...:|||  :.:....:.|..|...|:|.....|:.|        |.
Human   191 KSKKKEDELILKHELQ-LKKWKNRL--ILKRAAAEESNFPERSSSEVFLVDETLK--------CD 244

  Fly   277 LDL----------EYL---------DVSHNDFVVLPANGF-------------------GTLR-- 301
            :.|          .||         .|:|...::...|..                   .||:  
Human   245 ISLLPERAILQIFFYLSLKDVIICGQVNHAWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQRW 309

  Fly   302 RLRVLSVNNNGISMIAD--KALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISV 364
            ||.||.:|..|..:...  :::|..:|||.||:|.     .||                      
Human   310 RLNVLRLNFRGCLLRPKTFRSVSHCRNLQELNVSD-----CPT---------------------- 347

  Fly   365 LNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSH----NKLTKLEPEIFSDLYT 425
                 |:        |.||..|:.         |...::.||||:    |:..:|.|..|.:|..
Human   348 -----FT--------DESMRHISE---------GCPGVLCLNLSNTTITNRTMRLLPRHFHNLQN 390

  Fly   426 LQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPD 490
            |.:...|.                     .:...|:||:..  ||.:.|..|.|.....|.|  .
Human   391 LSLAYCRR---------------------FTDKGLQYLNLG--NGCHKLIYLDLSGCTQISV--Q 430

  Fly   491 AFR----NCSALQDLNLN------GNQLKTV------------------------PLALRNMRHL 521
            .||    :|:.:..|.:|      .|.:|.:                        .|:...:|.:
Human   431 GFRYIANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPHISDCTFRALSACKLRKI 495

  Fly   522 RTVDLGENMITVMEDSAFK-------GLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRI 579
            |..  |...:|   |::||       .|.::|.....|  :.:.::.:...|..|.:|||| |.:
Human   496 RFE--GNKRVT---DASFKFIDKNYPNLSHIYMADCKG--ITDSSLRSLSPLKQLTVLNLA-NCV 552

  Fly   580 AVVEPGAFEMTSSIQAVRLDGNELN----------DINGLFSNMPSLLWLNISD-NRLESFDYGH 633
            .:.:.|..:......::|:  .|||          .:..|....|:|.:|::.: ..|.:...|:
Human   553 RIGDMGLKQFLDGPASMRI--RELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQGIGY 615

  Fly   634 VPS-------TLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLN 691
            :.:       .|...|:....|:.||.      ..||:.|.||  :..||....|.     .|..
Human   616 IVNIFSLVSIDLSGTDISNEGLNVLSR------HKKLKELSVS--ECYRITDDGIQ-----AFCK 667

  Fly   692 DNLITTVDPDTFMHKTNLTRVDL-YANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNID 755
            .:||             |..:|: |.:|::.:.||:|.|..:    .|....|.|.|...|..::
Human   668 SSLI-------------LEHLDVSYCSQLSDMIIKALAIYCI----NLTSLSIAGCPKITDSAME 715

  Fly   756 WLQKINHITSRQYPRIMDLETIYCKLLNNR 785
            .|....|     |..|:|:..  |.||.::
Human   716 MLSAKCH-----YLHILDISG--CVLLTDQ 738

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 1/22 (5%)
LRR_8 171..236 CDD:290566 11/64 (17%)
leucine-rich repeat 172..201 CDD:275380 6/28 (21%)
leucine-rich repeat 202..278 CDD:275380 14/75 (19%)
leucine-rich repeat 229..249 CDD:275380 4/19 (21%)
LRR_RI 278..468 CDD:238064 43/235 (18%)
leucine-rich repeat 279..302 CDD:275380 8/62 (13%)
LRR_8 301..386 CDD:290566 19/88 (22%)
leucine-rich repeat 303..326 CDD:275380 6/24 (25%)
leucine-rich repeat 327..350 CDD:275380 7/22 (32%)
LRR 350..729 CDD:227223 86/442 (19%)
leucine-rich repeat 352..375 CDD:275380 1/22 (5%)
leucine-rich repeat 376..401 CDD:275380 5/24 (21%)
LRR_RI <401..626 CDD:238064 55/280 (20%)
leucine-rich repeat 402..425 CDD:275380 9/26 (35%)
leucine-rich repeat 426..449 CDD:275380 2/22 (9%)
leucine-rich repeat 450..473 CDD:275380 5/22 (23%)
leucine-rich repeat 474..497 CDD:275380 8/26 (31%)
leucine-rich repeat 498..518 CDD:275380 5/49 (10%)
leucine-rich repeat 521..544 CDD:275380 7/29 (24%)
leucine-rich repeat 545..566 CDD:275380 2/20 (10%)
leucine-rich repeat 569..592 CDD:275380 7/22 (32%)
leucine-rich repeat 593..615 CDD:275380 5/31 (16%)
leucine-rich repeat 616..637 CDD:275380 4/28 (14%)
leucine-rich repeat 638..662 CDD:275380 5/23 (22%)
leucine-rich repeat 663..684 CDD:275380 7/20 (35%)
leucine-rich repeat 685..708 CDD:275380 3/22 (14%)
leucine-rich repeat 709..728 CDD:275380 6/19 (32%)
LRR_8 883..943 CDD:290566
leucine-rich repeat 885..908 CDD:275380
leucine-rich repeat 909..932 CDD:275380
LRR_8 932..990 CDD:290566
leucine-rich repeat 933..956 CDD:275380
TIR 1114..1247 CDD:214587
FBXL13NP_001381423.1 Sfi1 <112..>224 CDD:400658 27/146 (18%)
F-box-like 245..289 CDD:403981 6/43 (14%)
leucine-rich repeat 285..312 CDD:275381 3/26 (12%)
AMN1 312..497 CDD:187754 49/258 (19%)
leucine-rich repeat 313..336 CDD:275381 5/22 (23%)
leucine-rich repeat 337..362 CDD:275381 13/73 (18%)
leucine-rich repeat 363..387 CDD:275381 8/23 (35%)
leucine-rich repeat 388..406 CDD:275381 4/38 (11%)
leucine-rich repeat 416..441 CDD:275381 8/26 (31%)
leucine-rich repeat 442..491 CDD:275381 5/48 (10%)
leucine-rich repeat 468..490 CDD:275381 1/21 (5%)
leucine-rich repeat 492..515 CDD:275381 7/27 (26%)
leucine-rich repeat 518..542 CDD:275381 4/25 (16%)
AMN1 529..737 CDD:187754 55/247 (22%)
leucine-rich repeat 543..570 CDD:275381 7/27 (26%)
leucine-rich repeat 571..596 CDD:275381 4/26 (15%)
leucine-rich repeat 597..645 CDD:275381 9/53 (17%)
leucine-rich repeat 646..671 CDD:275381 8/31 (26%)
leucine-rich repeat 672..697 CDD:275381 8/28 (29%)
leucine-rich repeat 698..723 CDD:275381 7/29 (24%)
leucine-rich repeat 724..749 CDD:275381 5/17 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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