DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and Tlr4

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_067272.1 Gene:Tlr4 / 21898 MGIID:96824 Length:835 Species:Mus musculus


Alignment Length:975 Identity:202/975 - (20%)
Similarity:384/975 - (39%) Gaps:284/975 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   353 QEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEP 417
            :.:.|..|.:.:|....|||..:||.||||..:|.:                          :|.
Mouse    56 KNIDLSFNPLKILKSYSFSNFSELQWLDLSRCEIET--------------------------IED 94

  Fly   418 EIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNN 482
            :.:..|:.|..|.|..|.:::.:..:|:.:.:|..|:....||..|:::.:..|..|..|::.:|
Mouse    95 KAWHGLHHLSNLILTGNPIQSFSPGSFSGLTSLENLVAVETKLASLESFPIGQLITLKKLNVAHN 159

  Fly   483 ALIGVH----PDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLR-------TVDLGENMITVMED 536
            .   :|    |..|.|.:.|..::|:.|.::|:  .:.:::.||       ::|:..|.|..::|
Mouse   160 F---IHSCKLPAYFSNLTNLVHVDLSYNYIQTI--TVNDLQFLRENPQVNLSLDMSLNPIDFIQD 219

  Fly   537 SAFKGLGNLYGLRLIGNY---------LENIT-MHT-------FRDLPNLQILNLARNRIAVVEP 584
            .||:|: .|:.|.|.||:         |:|:. :|.       |:|..||:|.          ||
Mouse   220 QAFQGI-KLHELTLRGNFNSSNIMKTCLQNLAGLHVHRLILGEFKDERNLEIF----------EP 273

  Fly   585 GAFEMTSSIQAVRLDGNEL---NDING------LFSNMPSLLWLNISDNRLESFDYGHVPSTLQW 640
            ...|   .:..|.:|...|   ||.:.      ..:|:.::....:|...||.     ||...:|
Mouse   274 SIME---GLCDVTIDEFRLTYTNDFSDDIVKFHCLANVSAMSLAGVSIKYLED-----VPKHFKW 330

  Fly   641 LDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMH 705
                                   |:|.:...||::.      .:::|.||. :|..|::..:...
Mouse   331 -----------------------QSLSIIRCQLKQF------PTLDLPFLK-SLTLTMNKGSISF 365

  Fly   706 K----TNLTRVDLYANQI--------TTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQ 758
            |    .:|:.:||..|.:        :.|...|||.|.:..:.|:          ....|...|:
Mouse   366 KKVALPSLSYLDLSRNALSFSGCCSYSDLGTNSLRHLDLSFNGAI----------IMSANFMGLE 420

  Fly   759 KINHITSR--------QYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCC 815
            ::.|:..:        ::...:.||    |||      |:.:.....|                .
Mouse   421 ELQHLDFQHSTLKRVTEFSAFLSLE----KLL------YLDISYTNTK----------------I 459

  Fly   816 EFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFL 880
            :||.....:|             |.|.::.:|.::.:                    ....:.|.
Mouse   460 DFDGIFLGLT-------------SLNTLKMAGNSFKD--------------------NTLSNVFA 491

  Fly   881 GRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIAS 945
            ...||..|..:...:..|....|..|.||.:|::..|:::.|:.:.::.|.:|..|....|:|.:
Mouse   492 NTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMSHNNLLFLDSSHYNQLYSLSTLDCSFNRIET 556

  Fly   946 IANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSE 1010
             :.|..|                ||.       ..|...:|.:|..:|.|.: .:|..::.:..:
Mouse   557 -SKGILQ----------------HFP-------KSLAFFNLTNNSVACICEH-QKFLQWVKEQKQ 596

  Fly  1011 KIIDASRVSC---IYNNATSVLREKNGTKCTLRDGVAHYMHTNEIE-GLLPLLLVATCAFVA--- 1068
            .:::..:::|   :..| ||::.:.|.:.|        ||:...|. .::.:::|:|.||:.   
Mouse   597 FLVNVEQMTCATPVEMN-TSLVLDFNNSTC--------YMYKTIISVSVVSVIVVSTVAFLIYHF 652

  Fly  1069 FFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQ 1133
            :|.||                   |:..|.|..|      .|...||:..||.|:|.:|...|.:
Mouse   653 YFHLI-------------------LIAGCKKYSR------GESIYDAFVIYSSQNEDWVRNELVK 692

  Fly  1134 TLENDI-GYRLCLHYRDVNINAYITDALI-EAAESAKQFVLVLSKNFLYNEWSRFEYKSA-LHEL 1195
            .||..: .:.|||||||......|...:| |....:::.::|:|::|:.:.|..|||:.| ..:.
Mouse   693 NLEEGVPRFHLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQF 757

  Fly  1196 VKRRKRVVFILYGDLPQRDIDMDMRHY--LRTSTCIEWDDKK-----FWQKLRLALPLPNGRGNN 1253
            :..|..::||:...:.:..:...:..|  |..:|.:||:|..     ||::|:.|  |.:|:.:|
Mouse   758 LSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDNPLGRHIFWRRLKNA--LLDGKASN 820

  Fly  1254  1253
            Mouse   821  820

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 25/114 (22%)
leucine-rich repeat 279..302 CDD:275380
LRR_8 301..386 CDD:290566 12/32 (38%)
leucine-rich repeat 303..326 CDD:275380
leucine-rich repeat 327..350 CDD:275380
LRR 350..729 CDD:227223 91/424 (21%)
leucine-rich repeat 352..375 CDD:275380 6/21 (29%)
leucine-rich repeat 376..401 CDD:275380 7/24 (29%)
LRR_RI <401..626 CDD:238064 56/261 (21%)
leucine-rich repeat 402..425 CDD:275380 2/22 (9%)
leucine-rich repeat 426..449 CDD:275380 5/22 (23%)
leucine-rich repeat 450..473 CDD:275380 6/22 (27%)
leucine-rich repeat 474..497 CDD:275380 7/26 (27%)
leucine-rich repeat 498..518 CDD:275380 4/19 (21%)
leucine-rich repeat 521..544 CDD:275380 9/29 (31%)
leucine-rich repeat 545..566 CDD:275380 9/37 (24%)
leucine-rich repeat 569..592 CDD:275380 5/22 (23%)
leucine-rich repeat 593..615 CDD:275380 6/30 (20%)
leucine-rich repeat 616..637 CDD:275380 5/20 (25%)
leucine-rich repeat 638..662 CDD:275380 1/23 (4%)
leucine-rich repeat 663..684 CDD:275380 4/20 (20%)
leucine-rich repeat 685..708 CDD:275380 6/26 (23%)
leucine-rich repeat 709..728 CDD:275380 6/26 (23%)
LRR_8 883..943 CDD:290566 15/59 (25%)
leucine-rich repeat 885..908 CDD:275380 5/22 (23%)
leucine-rich repeat 909..932 CDD:275380 5/22 (23%)
LRR_8 932..990 CDD:290566 10/57 (18%)
leucine-rich repeat 933..956 CDD:275380 6/22 (27%)
TIR 1114..1247 CDD:214587 41/142 (29%)
Tlr4NP_067272.1 LRR_8 53..113 CDD:290566 19/82 (23%)
LRR 1 54..75 4/18 (22%)
leucine-rich repeat 58..78 CDD:275380 6/19 (32%)
LRR 2 78..99 8/46 (17%)
leucine-rich repeat 79..102 CDD:275380 9/48 (19%)
LRR 3 102..123 5/20 (25%)
leucine-rich repeat 103..126 CDD:275380 5/22 (23%)
LRR 4 126..147 5/20 (25%)
leucine-rich repeat 127..150 CDD:275380 6/22 (27%)
LRR_8 150..214 CDD:290566 15/68 (22%)
LRR 5 150..171 5/23 (22%)
leucine-rich repeat 151..175 CDD:275380 7/26 (27%)
LRR 6 175..198 4/24 (17%)
leucine-rich repeat 176..204 CDD:275380 6/29 (21%)
LRR 7 204..224 6/19 (32%)
leucine-rich repeat 205..226 CDD:275380 7/21 (33%)
LRR 8 226..247 5/20 (25%)
LRR 9 248..269 5/20 (25%)
LRR 10 329..349 5/48 (10%)
leucine-rich repeat 331..350 CDD:275380 5/24 (21%)
LRR 11 350..370 5/20 (25%)
leucine-rich repeat 351..372 CDD:275380 4/21 (19%)
LRR_RI <369..555 CDD:238064 42/254 (17%)
LRR 12 372..392 4/19 (21%)
leucine-rich repeat 373..398 CDD:275380 5/24 (21%)
LRR 13 398..420 6/31 (19%)
leucine-rich repeat 399..421 CDD:275380 6/31 (19%)
LRR 14 421..442 1/20 (5%)
leucine-rich repeat 422..446 CDD:275380 3/27 (11%)
LRR 15 446..467 7/42 (17%)
leucine-rich repeat 447..470 CDD:275380 7/57 (12%)
LRR 16 470..490 3/39 (8%)
leucine-rich repeat 471..495 CDD:275380 3/43 (7%)
LRR_8 494..554 CDD:290566 15/59 (25%)
LRR 17 495..516 5/20 (25%)
leucine-rich repeat 496..519 CDD:275380 5/22 (23%)
LRR 18 519..540 5/20 (25%)
leucine-rich repeat 520..543 CDD:275380 5/22 (23%)
LRR 19 543..564 6/37 (16%)
Interaction with SCIMP. /evidence=ECO:0000269|PubMed:28098138 670..835 44/153 (29%)
TIR 672..813 CDD:214587 41/142 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.820

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