DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and Lrtm2

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001165678.1	Gene:	Lrtm2 / 211187	MGIID:	2141485	Length:	370	Species:	Mus musculus

Alignment Length:	332	Identity:	75/332 - (22%)
Similarity:	125/332 - (37%)	Gaps:	72/332 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   815 CEFDACDCEM--TCPTNCTCFHDQTWSTNI-VECSGAAYSEMPRRVPMDTSELYIDGNNFVELAG 876
            |....|..|:  .||.:|||.     |.:: |:|||...:.:|..||..|..|.:..|....|..
Mouse    26 CWIALCAVEVIPACPFSCTCD-----SRSLEVDCSGLGLTTVPPDVPAATQSLLLLNNKLSALPS 85

  Fly   877 HSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSN 941
            .:|....||..|..:|:.:..:..:.|..|..|..|.|.:|.|.:|:.:...:...||.|.|..|
Mouse    86 WAFANLSNLQRLDLSNNFLDQLPRSIFEDLVNLTELQLRNNSIRTLDRDLLQHSPLLRHLDLSIN 150

  Fly   942 KIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPY--LVEISLADNQWSCECGYLARFRNY 1004
            .:|.:..|.|..|..|..|.|..|||...:  :|:..|.  |..:.:.||.|.|:|. |..|:::
Mouse   151 GLAQLPPGLFDGLLALRSLSLRSNRLQSLD--RLTFEPLASLQLLQVGDNPWECDCN-LREFKHW 212

  Fly  1005 LGQSSEKIIDASRVSC-----------------IYNNATSVLREKN-------GTKCT------- 1038
            |...|.:.....:::|                 ::|..:.:..|.|       |..||
Mouse   213 LEWFSYRGGRLDQLACTLPKELRGKDMRAVPMEMFNYCSQLEDENNSAGLDAPGPPCTKASPEPP 277

  Fly  1039 --------------------------LRDGVAHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGLF 1077
                                      :|..:...:....:.|::.:::|...|:...:..:...
Mouse   278 KPKPGAEPEPEPSTACPQKQRYRPVSVRRAIGTVIIAGVVCGIVCIMMVVAAAYGCIYASLMAK- 341

  Fly  1078 CYRHELK 1084
             |..|||
Mouse   342 -YHRELK 347

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR	350..729	CDD:227223
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		LRR_RI	<401..626	CDD:238064
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	426..449	CDD:275380
		leucine-rich repeat	450..473	CDD:275380
		leucine-rich repeat	474..497	CDD:275380
		leucine-rich repeat	498..518	CDD:275380
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..566	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		leucine-rich repeat	593..615	CDD:275380
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566	17/59 (29%)
		leucine-rich repeat	885..908	CDD:275380	5/22 (23%)
		leucine-rich repeat	909..932	CDD:275380	6/22 (27%)
		LRR_8	932..990	CDD:290566	19/59 (32%)
		leucine-rich repeat	933..956	CDD:275380	9/22 (41%)
		TIR	1114..1247	CDD:214587
Lrtm2	NP_001165678.1	LRRNT	38..67	CDD:396168	11/33 (33%)
		leucine-rich repeat	51..93	CDD:275378	12/41 (29%)
		LRR 1	69..90		5/20 (25%)
		LRR_8	92..152	CDD:404697	17/59 (29%)
		LRR 2	93..114		5/20 (25%)
		leucine-rich repeat	94..117	CDD:275378	5/22 (23%)
		LRR 3	117..138		6/20 (30%)
		leucine-rich repeat	118..141	CDD:275378	6/22 (27%)
		LRR 4	141..162		8/20 (40%)
		leucine-rich repeat	142..189	CDD:275378	17/48 (35%)
		LRR 5	165..186		7/22 (32%)
		leucine-rich repeat	166..186	CDD:275380	7/21 (33%)
		leucine-rich repeat	190..202	CDD:275378	4/11 (36%)
		TPKR_C2	198..247	CDD:417692	9/49 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	260..297		3/36 (8%)
		Herpes_glycop_D	<261..335	CDD:421518	7/73 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	351..370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45836
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100