DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and Slit3

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_035542.2 Gene:Slit3 / 20564 MGIID:1315202 Length:1523 Species:Mus musculus


Alignment Length:1635 Identity:333/1635 - (20%)
Similarity:546/1635 - (33%) Gaps:622/1635 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 QQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIW 213
            ::|.:....:.|:.:....||:.||.|.|..:.:      ..||..||...::||||.|:.|.:.
Mouse    64 ERLDLDRNNITRITKMDFAGLKNLRVLHLEDNQV------SIIERGAFQDLKQLERLRLNKNKLQ 122

  Fly   214 SLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLD 278
            .||:.:|.:..:|:.|::|||::|.:....||        |.|                     .
Mouse   123 VLPELLFQSTPKLTRLDLSENQIQGIPRKAFR--------GVT---------------------G 158

  Fly   279 LEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKI------ 337
            ::.|.:.:|....:....|..||.|.:|::|||.||.|...:.:.:..::.|.|.||.:      
Mouse   159 VKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVTSFNHMPKIRTLRLHSNHLYCDCHL 223

  Fly   338 ------------------------------------------------------VALP------- 341
                                                                  ::.|       
Mouse   224 AWLSDWLRQRRTIGQFTLCMAPVHLRGFSVADVQKKEYVCPGPHSEAPACNANSLSCPSACSCSN 288

  Fly   342 ----------TELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITS-------- 388
                      ||:.|...:.|.|:.|:.|||..:....|:...:|:.:|:|.|||:.        
Mouse   289 NIVDCRGKGLTEIPANLPEGIVEIRLEQNSIKSIPAGAFTQYKKLKRIDISKNQISDIAPDAFQG 353

  Fly   389 --------------TWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENI 439
                          |.|.|..|.||:.|.||.|:.||:..|....|.||..|.:|:|..|:|:.|
Mouse   354 LKSLTSLVLYGNKITEIPKGLFDGLVSLQLLLLNANKINCLRVNTFQDLQNLNLLSLYDNKLQTI 418

  Fly   440 AADTFAPMNNLHTLLLSHN------KLKYLDAY------ALNGLYVLSLLSLDNNALIGVHPDAF 492
            :...|.|:.::.||.|:.|      .||:|..|      ..:|....|...|.|..:..:....|
Mouse   419 SKGLFVPLQSIQTLHLAQNPFVCDCHLKWLADYLQDNPIETSGARCSSPRRLANKRISQIKSKKF 483

  Fly   493 RNCSALQD-------------------------LNLNGNQLKTVPLALRNMRHL--RTVD--LGE 528
            | ||..:|                         ::.:..:|..:|      .||  .|.|  |.:
Mouse   484 R-CSGSEDYRNRFSSECFMDLVCPEKCRCEGTIVDCSNQKLARIP------SHLPEYTTDLRLND 541

  Fly   529 NMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSI 593
            |.|:|:|.:..                       |:.||||:.:||:.|||..|..|||:..:.:
Mouse   542 NDISVLEATGI-----------------------FKKLPNLRKINLSNNRIKEVREGAFDGAAGV 583

  Fly   594 QAVRLDGNELNDING-LFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGL 657
            |.:.|.||:|..::| :|..:                      |:|:.|.|..|.:|.:||.   
Mouse   584 QELMLTGNQLETMHGRMFRGL----------------------SSLKTLMLRSNLISCVSND--- 623

  Fly   658 DSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTL 722
                       :|..|         :|:.||.|.||.|||:.|..|....:|:.::|.:      
Mouse   624 -----------TFAGL---------SSVRLLSLYDNRITTITPGAFTTLVSLSTINLLS------ 662

  Fly   723 DIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQY----PRIMDLETIYCKLLN 783
                                   |||.|:|::.||.:  .:..|:.    ||..  :..:.|   
Mouse   663 -----------------------NPFNCNCHMAWLGR--WLRKRRIVSGNPRCQ--KPFFLK--- 697

  Fly   784 NRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGA 848
                 .||:.:...:.|.|...          |..:|.....||..|||..      .:|.||..
Mouse   698 -----EIPIQDVAIQDFTCDGN----------EESSCQLSPRCPEQCTCVE------TVVRCSNR 741

  Fly   849 AYSEMPRRVPMDTSELYIDGNNFV----ELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRL 909
            ....:|:.:|.|.:|||::||:..    ||:..     :.|.::..:|::::.:.|.|||.:..|
Mouse   742 GLHALPKGMPKDVTELYLEGNHLTAVPKELSAF-----RQLTLIDLSNNSISMLTNHTFSNMSHL 801

  Fly   910 LILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEV-- 972
            ..|.|..|.:..:..:.|:.|.:||.|.|..|.|:|:..|||..|..|..|.| |...:|.:.  
Mouse   802 STLILSYNRLRCIPVHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLAL-GTNPLHCDCSL 865

  Fly   973 -----WQLSA--NPYLVEI----SLAD-------------------------------------- 988
                 |..:.  .|.:...    |:||                                      
Mouse   866 RWLSEWVKAGYKEPGIARCSSPESMADRLLLTTPTHRFQCKGPVDINIVAKCNACLSSPCKNNGT 930

  Fly   989 ------NQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYN----NATSVLREK----------- 1032
                  .|:.|.|.|     :|.|:.....|:    :|:.|    ..|..|.|.           
Mouse   931 CSQDPVEQYRCTCPY-----SYKGKDCTVPIN----TCVQNPCEHGGTCHLSENLRDGFSCSCPL 986

  Fly  1033 --NGTKC----------------TLRDGVAHYM------HTNE-----IEGLLPLLLV----ATC 1064
              .|.:|                |..||:.:|.      :|.|     |:..:|.:.:    |.|
Mouse   987 GFEGQRCEINPDDCEDNDCENSATCVDGINNYACLCPPNYTGELCDEVIDYCVPEMNLCQHEAKC 1051

  Fly  1065 AFVAFFGLIFGLFC-----YRHELKIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQD- 1123
                 ..|..|..|     |..:| ...::.:|:.:.|....:.||::      :.|.....|. 
Mouse  1052 -----ISLDKGFRCECVPGYSGKL-CETNNDDCVAHKCRHGAQCVDEV------NGYTCICPQGF 1104

  Fly  1124 -----EHFVNQILAQTLENDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVL----------- 1172
                 ||....:|.||..       |..|              |....|:..|:           
Mouse  1105 SGLFCEHPPPMVLLQTSP-------CDQY--------------ECQNGAQCIVVQQEPTCRCPPG 1148

  Fly  1173 --------VLSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGDLPQRDIDMDMRHYLRTSTCI 1229
                    :::.||:        .|.:..||...:.|         ||.:|              
Mouse  1149 FAGPRCEKLITVNFV--------GKDSYVELASAKVR---------PQANI-------------- 1182

  Fly  1230 EWDDKKFWQKLRLALPLPNG----RGNNNK----------RVVSGCLSGRTPSVNMYATSHEYQA 1280
                     .|::|....||    :|:|:.          |:|...||  :|...:|:.    :.
Mouse  1183 ---------SLQVATDKDNGILLYKGDNDPLALELYQGHVRLVYDSLS--SPPTTVYSV----ET 1232

  Fly  1281 GNGG--------VIPPPSARYADCGS-NNYATINECAAAG-------GGRGYKPIPTSASAAAAA 1329
            .|.|        ::........|.|: .:...:.:..|.|       ||     ||||...:|. 
Mouse  1233 VNDGQFHSVELVMLNQTLNLVVDKGAPKSLGKLQKQPAVGSNSPLYLGG-----IPTSTGLSAL- 1291

  Fly  1330 CKFNTMNQLSKKQQRDLSVAGMAKTLEHQHHHNHQANRRSQHEYAVPSYLPSAAPAYDSVDYAKQ 1394
                       :|..|..:.|.     |...|..:.|...|...|:|......:|...|....:.
Mouse  1292 -----------RQGADRPLGGF-----HGCIHEVRINNELQDFKALPPQSLGVSPGCKSCTVCRH 1340

  Fly  1395 QI-----RNNANCECVN--LGTAKRAAGKNPASGLPSSFSSNFVPPGGASYNCKK-SCSCIGDDE 1451
            .:     :::..|||..  .|.......::|..|                ::|:. :|...| |.
Mouse  1341 GLCRSVEKDSVVCECHPGWTGPLCDQEARDPCLG----------------HSCRHGTCMATG-DS 1388

  Fly  1452 LLCSCGGGGG 1461
            .:|.|..|.|
Mouse  1389 YVCKCAEGYG 1398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 4/21 (19%)
LRR_8 171..236 CDD:290566 22/64 (34%)
leucine-rich repeat 172..201 CDD:275380 8/28 (29%)
leucine-rich repeat 202..278 CDD:275380 19/75 (25%)
leucine-rich repeat 229..249 CDD:275380 7/19 (37%)
LRR_RI 278..468 CDD:238064 66/300 (22%)
leucine-rich repeat 279..302 CDD:275380 4/22 (18%)
LRR_8 301..386 CDD:290566 28/161 (17%)
leucine-rich repeat 303..326 CDD:275380 8/22 (36%)
leucine-rich repeat 327..350 CDD:275380 8/99 (8%)
LRR 350..729 CDD:227223 109/442 (25%)
leucine-rich repeat 352..375 CDD:275380 7/22 (32%)
leucine-rich repeat 376..401 CDD:275380 12/46 (26%)
LRR_RI <401..626 CDD:238064 67/266 (25%)
leucine-rich repeat 402..425 CDD:275380 10/22 (45%)
leucine-rich repeat 426..449 CDD:275380 8/22 (36%)
leucine-rich repeat 450..473 CDD:275380 9/34 (26%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
leucine-rich repeat 498..518 CDD:275380 3/44 (7%)
leucine-rich repeat 521..544 CDD:275380 8/26 (31%)
leucine-rich repeat 545..566 CDD:275380 1/20 (5%)
leucine-rich repeat 569..592 CDD:275380 10/22 (45%)
leucine-rich repeat 593..615 CDD:275380 7/22 (32%)
leucine-rich repeat 616..637 CDD:275380 0/20 (0%)
leucine-rich repeat 638..662 CDD:275380 7/23 (30%)
leucine-rich repeat 663..684 CDD:275380 2/20 (10%)
leucine-rich repeat 685..708 CDD:275380 10/22 (45%)
leucine-rich repeat 709..728 CDD:275380 2/18 (11%)
LRR_8 883..943 CDD:290566 17/59 (29%)
leucine-rich repeat 885..908 CDD:275380 6/22 (27%)
leucine-rich repeat 909..932 CDD:275380 6/22 (27%)
LRR_8 932..990 CDD:290566 21/114 (18%)
leucine-rich repeat 933..956 CDD:275380 11/22 (50%)
TIR 1114..1247 CDD:214587 23/157 (15%)
Slit3NP_035542.2 LRRNT 33..60 CDD:279764
LRR_RI <49..220 CDD:238064 48/190 (25%)
LRR_8 61..121 CDD:290566 18/62 (29%)
LRR 1 62..83 2/18 (11%)
leucine-rich repeat 64..86 CDD:275380 4/21 (19%)
LRR 2 86..107 8/26 (31%)
leucine-rich repeat 87..110 CDD:275380 8/28 (29%)
LRR_8 109..169 CDD:290566 21/88 (24%)
LRR 3 110..131 9/20 (45%)
leucine-rich repeat 111..134 CDD:275380 9/22 (41%)
LRR 4 134..155 8/28 (29%)
leucine-rich repeat 135..158 CDD:275380 10/51 (20%)
LRR_8 157..217 CDD:290566 18/80 (23%)
LRR 5 158..179 3/20 (15%)
leucine-rich repeat 159..182 CDD:275380 4/22 (18%)
LRR 6 182..203 8/20 (40%)
leucine-rich repeat 183..206 CDD:275380 8/22 (36%)
leucine-rich repeat 207..309 CDD:275380 8/101 (8%)
LRRNT 280..311 CDD:214470 5/30 (17%)
LRR 7 308..329 7/20 (35%)
LRR_8 311..367 CDD:290566 12/55 (22%)
leucine-rich repeat 311..332 CDD:275380 6/20 (30%)
LRR_4 331..371 CDD:289563 7/39 (18%)
LRR 8 332..353 6/20 (30%)
leucine-rich repeat 333..356 CDD:275380 6/22 (27%)
LRR_8 355..439 CDD:290566 28/83 (34%)
LRR 9 356..377 4/20 (20%)
leucine-rich repeat 357..377 CDD:275380 4/19 (21%)
LRR 10 380..401 8/20 (40%)
leucine-rich repeat 381..404 CDD:275380 10/22 (45%)
LRR 11 404..425 7/20 (35%)
leucine-rich repeat 405..426 CDD:275380 7/20 (35%)
leucine-rich repeat 429..522 CDD:275380 17/93 (18%)
TPKR_C2 437..>467 CDD:301599 6/29 (21%)
LRRNT 505..535 CDD:214470 4/35 (11%)
LRR 12 533..554 7/43 (16%)
leucine-rich repeat 534..558 CDD:275380 9/46 (20%)
LRR_4 535..574 CDD:289563 17/61 (28%)
LRR_8 557..617 CDD:290566 24/81 (30%)
LRR 13 558..579 11/20 (55%)
leucine-rich repeat 559..582 CDD:275380 10/22 (45%)
LRR 14 582..603 7/20 (35%)
leucine-rich repeat 583..606 CDD:275380 7/44 (16%)
LRR_8 605..665 CDD:290566 24/111 (22%)
LRR 15 606..627 8/34 (24%)
leucine-rich repeat 607..630 CDD:275380 9/45 (20%)
LRR 16 630..651 11/20 (55%)
leucine-rich repeat 631..654 CDD:275380 10/22 (45%)
leucine-rich repeat 655..745 CDD:275380 27/146 (18%)
LRRCT 663..712 CDD:214507 14/60 (23%)
LRRNT 725..756 CDD:214470 11/36 (31%)
leucine-rich repeat 746..776 CDD:275380 10/34 (29%)
LRR_RI <751..869 CDD:238064 37/123 (30%)
LRR 17 753..774 8/20 (40%)
LRR_8 775..835 CDD:290566 17/59 (29%)
LRR 18 776..797 5/20 (25%)
leucine-rich repeat 777..800 CDD:275380 6/22 (27%)
LRR 19 800..821 5/20 (25%)
leucine-rich repeat 801..824 CDD:275380 6/22 (27%)
LRR 20 824..845 10/20 (50%)
leucine-rich repeat 825..846 CDD:275380 10/20 (50%)
LRRCT 857..906 CDD:214507 6/48 (13%)
EGF_CA 956..994 CDD:238011 7/41 (17%)
EGF_CA 998..1031 CDD:238011 6/32 (19%)
EGF_CA 1035..1072 CDD:238011 9/42 (21%)
EGF_CA 1076..1110 CDD:238011 6/39 (15%)
EGF 1123..1153 CDD:278437 5/43 (12%)
Laminin_G_2 1188..1314 CDD:280389 29/153 (19%)
GHB_like 1463..1519 CDD:304424
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45836
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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