DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and Slit2

DIOPT Version :10

Sequence 1:NP_524081.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001278156.1 Gene:Slit2 / 20563 MGIID:1315205 Length:1542 Species:Mus musculus


Alignment Length:1622 Identity:324/1622 - (19%)
Similarity:535/1622 - (32%) Gaps:576/1622 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 QQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIW 213
            ::|.:....:.|:.:....||..||.|.|..:.|      ..||..||...:.||||.|:.||:.
Mouse    58 ERLDLNGNNITRITKIDFAGLRHLRVLQLMENRI------STIERGAFQDLKELERLRLNRNNLQ 116

  Fly   214 SLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLD 278
            ..|:.:|...::|..|::|||::|.:....||.                             ::|
Mouse   117 LFPELLFLGTAKLYRLDLSENQIQAIPRKAFRG-----------------------------AVD 152

  Fly   279 LEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNK------- 336
            ::.|.:.:|....:....|..||.|.||::|||.|:.::..:.:.:..|:...|.||.       
Mouse   153 IKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHL 217

  Fly   337 ----------------------------------------------------------------- 336
                                                                             
Mouse   218 AWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSDEEEGHQSFMAPSCSVLHCPAACT 282

  Fly   337 ------------IVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITS- 388
                        :..:||.|    .:.|.|:.|:.|||.|:.|..||...:|:.||||.|||:. 
Mouse   283 CSNNIVDCRGKGLTEIPTNL----PETITEIRLEQNSIRVIPPGAFSPYKKLRRLDLSNNQISEL 343

  Fly   389 ---------------------TWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLR 432
                                 |.:.|:.|.||..|.||.|:.||:..|..:.|.||:.|.:|:|.
Mouse   344 APDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLY 408

  Fly   433 HNQLENIAADTFAPMNNLHTLLLSHN------KLKYLDAY------ALNGLYVLSLLSLDNNALI 485
            .|:|:.:|..||:.:..:.|:.|:.|      .||:|..|      ..:|....|...|.|..:.
Mouse   409 DNKLQTVAKGTFSALRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIG 473

  Fly   486 GVHPDAFRNCSALQDLNLNGNQ---------------------------------LKTVPLALRN 517
            .:....|| |||.:...:.|.:                                 |..:|..:  
Mouse   474 QIKSKKFR-CSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQRLNKIPDHI-- 535

  Fly   518 MRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVV 582
            .::...:.|..|..||:|.:..                       |:.||.|:.:|.:.|:|..:
Mouse   536 PQYTAELRLNNNEFTVLEATGI-----------------------FKKLPQLRKINFSNNKITDI 577

  Fly   583 EPGAFEMTSSIQAVRLDGNELNDI-NGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKN 646
            |.||||..|.:..:.|..|.|.:: :.:|..:.|                      |:.|.|..|
Mouse   578 EEGAFEGASGVNEILLTSNRLENVQHKMFKGLES----------------------LKTLMLRSN 620

  Fly   647 RLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTR 711
            |:|.:.|    ||.:.|                   .|:.||.|.||.||||.|..|....:|:.
Mouse   621 RISCVGN----DSFIGL-------------------GSVRLLSLYDNQITTVAPGAFDSLHSLST 662

  Fly   712 VDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNI----DWLQKINHITSRQYPRIM 772
            ::|.|                             |||.|:|::    :||::...:|..  ||  
Mouse   663 LNLLA-----------------------------NPFNCNCHLAWLGEWLRRKRIVTGN--PR-- 694

  Fly   773 DLETIYCKLLNNRERAY----IPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCF 833
                  |      ::.|    ||:.:...:.|.|....         :.::|.....||:.|||.
Mouse   695 ------C------QKPYFLKEIPIQDVAIQDFTCDDGN---------DDNSCSPLSRCPSECTCL 738

  Fly   834 HDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFV----ELAGHSFLGRKNLAVLYANNSN 894
                  ..:|.||......:|:.:|.|.:|||:|||.|.    ||:.:     |:|.::..:|:.
Mouse   739 ------DTVVRCSNKGLKVLPKGIPKDVTELYLDGNQFTLVPKELSNY-----KHLTLIDLSNNR 792

  Fly   895 VAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEV 959
            ::.:.|.:||.:.:||.|.|..|.:..:....|..|::||.|.|..|.|:.:..|:|..|..|..
Mouse   793 ISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSH 857

  Fly   960 LRLDGN------RLMHFEVW------------------------------------------QLS 976
            |.:..|      .:.....|                                          |..
Mouse   858 LAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDITIQAK 922

  Fly   977 ANPYLVEISLADNQ--------WSCECGYLARFRNYLGQSSEKIIDASRVSCIYN----NATSVL 1029
            .||.|......|..        :.|.|.|     .:.||..:..|.|    ||.|    ..|..|
Mouse   923 CNPCLSNPCKNDGTCNNDPVDFYRCTCPY-----GFKGQDCDVPIHA----CISNPCKHGGTCHL 978

  Fly  1030 RE-------------------------------KNGTKCTLRDGVAHY----------MHTNEIE 1053
            :|                               :|.:.|.  ||:.:|          .:.||:|
Mouse   979 KEGENAGFWCTCADGFEGENCEVNIDDCEDNDCENNSTCV--DGINNYTCLCPPEYTAANLNEVE 1041

  Fly  1054 -GLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMN----FCYKSPRFVDQLDKERPN 1113
             |.|....:..||               .:|....|.:.|::.    .|..:|.::         
Mouse  1042 KGELCEEKLDFCA---------------QDLNPCQHDSKCILTPKGFKCDCTPGYI--------- 1082

  Fly  1114 DAYFAYSLQDEHFVNQILAQTLENDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNF 1178
                     .||.           ||.:..|...:..| .|:.|||:       ..:..|..:.:
Mouse  1083 ---------GEHC-----------DIDFDDCQDNKCKN-GAHCTDAV-------NGYTCVCPEGY 1119

  Fly  1179 --LYNEWS------------RFEYKSALHELVKRRKRVVFILYGDLPQRDIDMDMRHYLRTSTCI 1229
              |:.|:|            .|:.::....:::..:.:...|.|.|.::...:...:::...:.:
Mouse  1120 SGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIIRINEPICQCLPGYLGEKCEKLVSVNFVNKESYL 1184

  Fly  1230 EWDDKKFWQKLRLALPLPNGRGNNNKRVVSGCLSGRTP----SVNMY--ATSHEYQAGNGGVIPP 1288
            :....|...:..:.|.:.....       ||.|..:..    :|.:|  .....|..|:    .|
Mouse  1185 QIPSAKVRPQTNITLQIATDED-------SGILLYKGDKDHIAVELYRGRVRASYDTGS----HP 1238

  Fly  1289 PSARYA--DCGSNNY-----ATINECAAAGGGRGYKPIPTSASAAAAACKFNTMN---------Q 1337
            .||.|:  .....|:     .|::...:.....|...:.|:.|      |.:|:|         .
Mouse  1239 ASAIYSVETINDGNFHIVELLTLDSSLSLSVDGGSPKVITNLS------KQSTLNFDSPLYVGGM 1297

  Fly  1338 LSKKQQRDLSVA-GMAKTLEHQHHHNHQANRRSQHEYAVP---SYLPSAAPAYDSV---DYAKQQ 1395
            ..|.....|..| |...|..|....|...|...|....:|   ..||...|.:..|   ...:..
Mouse  1298 PGKNNVASLRQAPGQNGTSFHGCIRNLYINSELQDFRKMPMQTGILPGCEPCHKKVCAHGMCQPS 1362

  Fly  1396 IRNNANCECVN--LGTAKRAAGKNPASGLPSSFSSNFVPPGGASYNCKKSCSCI-GDDELLC 1454
            .::...|||..  :|........:|..| ........:|....||:||    |: |...:||
Mouse  1363 SQSGFTCECEEGWMGPLCDQRTNDPCLG-NKCVHGTCLPINAFSYSCK----CLEGHGGVLC 1419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_524081.1 PPP1R42 <135..>242 CDD:455733 28/92 (30%)
leucine-rich repeat 148..171 CDD:275380 4/21 (19%)
leucine-rich repeat 172..201 CDD:275380 9/28 (32%)
LRR_8 200..>246 CDD:404697 16/45 (36%)
leucine-rich repeat 202..278 CDD:275380 17/75 (23%)
leucine-rich repeat 229..249 CDD:275380 7/19 (37%)
leucine-rich repeat 279..302 CDD:275380 4/22 (18%)
LRR 299..654 CDD:443914 105/506 (21%)
leucine-rich repeat 303..326 CDD:275380 7/22 (32%)
leucine-rich repeat 327..350 CDD:275380 7/106 (7%)
leucine-rich repeat 352..375 CDD:275380 10/22 (45%)
leucine-rich repeat 376..401 CDD:275380 13/46 (28%)
leucine-rich repeat 402..425 CDD:275380 10/22 (45%)
leucine-rich repeat 426..449 CDD:275380 8/22 (36%)
leucine-rich repeat 450..473 CDD:275380 8/34 (24%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
leucine-rich repeat 498..518 CDD:275380 3/52 (6%)
leucine-rich repeat 521..544 CDD:275380 5/22 (23%)
leucine-rich repeat 545..566 CDD:275380 1/20 (5%)
leucine-rich repeat 569..592 CDD:275380 9/22 (41%)
leucine-rich repeat 593..615 CDD:275380 4/22 (18%)
leucine-rich repeat 616..637 CDD:275380 0/20 (0%)
leucine-rich repeat 638..662 CDD:275380 9/23 (39%)
LRR_8 662..719 CDD:404697 16/56 (29%)
leucine-rich repeat 663..684 CDD:275380 1/20 (5%)
leucine-rich repeat 685..708 CDD:275380 11/22 (50%)
leucine-rich repeat 709..728 CDD:275380 3/18 (17%)
LRR <863..>990 CDD:443914 40/178 (22%)
leucine-rich repeat 885..908 CDD:275380 5/22 (23%)
leucine-rich repeat 909..932 CDD:275380 7/22 (32%)
leucine-rich repeat 933..956 CDD:275380 9/22 (41%)
TIR 1114..1247 CDD:214587 20/146 (14%)
Slit2NP_001278156.1 LRRNT 27..58 CDD:214470 324/1622 (20%)
leucine-rich repeat 38..56 CDD:275380
LRR <56..>211 CDD:443914 47/187 (25%)
LRR 1 56..77 2/18 (11%)
leucine-rich repeat 57..80 CDD:275380 4/21 (19%)
LRR 2 80..101 9/26 (35%)
leucine-rich repeat 81..104 CDD:275380 9/28 (32%)
LRR 3 104..125 9/20 (45%)
leucine-rich repeat 105..128 CDD:275380 9/22 (41%)
LRR 4 128..149 7/20 (35%)
leucine-rich repeat 129..152 CDD:275380 8/51 (16%)
LRR 5 152..173 4/20 (20%)
leucine-rich repeat 153..176 CDD:275380 4/22 (18%)
LRR 6 176..197 7/20 (35%)
leucine-rich repeat 177..200 CDD:275380 7/22 (32%)
PCC 182..>260 CDD:188093 8/77 (10%)
leucine-rich repeat 201..329 CDD:275380 17/131 (13%)
LRR <287..>456 CDD:443914 51/172 (30%)
LRR 7 305..326 9/20 (45%)
LRR 8 329..350 8/20 (40%)
leucine-rich repeat 330..353 CDD:275380 8/22 (36%)
LRR 9 353..374 3/20 (15%)
leucine-rich repeat 354..374 CDD:275380 3/19 (16%)
LRR 10 377..398 8/20 (40%)
leucine-rich repeat 378..401 CDD:275380 10/22 (45%)
LRR 11 401..422 8/20 (40%)
leucine-rich repeat 402..423 CDD:275380 8/20 (40%)
leucine-rich repeat 426..527 CDD:275380 17/101 (17%)
LRR <519..>670 CDD:443914 51/249 (20%)
LRR 12 538..559 5/43 (12%)
leucine-rich repeat 541..563 CDD:275380 7/44 (16%)
LRR 13 563..584 8/20 (40%)
leucine-rich repeat 564..587 CDD:275380 9/22 (41%)
LRR 14 587..608 4/20 (20%)
leucine-rich repeat 588..611 CDD:275380 4/22 (18%)
LRR 15 611..632 10/46 (22%)
leucine-rich repeat 612..635 CDD:275380 10/45 (22%)
LRR 16 635..656 12/20 (60%)
leucine-rich repeat 636..659 CDD:275380 11/22 (50%)
PCC 641..>717 CDD:188093 27/120 (23%)
leucine-rich repeat 660..751 CDD:275380 28/150 (19%)
LRR <740..>865 CDD:443914 40/129 (31%)
leucine-rich repeat 752..782 CDD:275380 12/34 (35%)
LRR 17 759..781 10/26 (38%)
LRR 18 782..803 4/20 (20%)
leucine-rich repeat 783..806 CDD:275380 5/22 (23%)
LRR 19 806..827 6/20 (30%)
leucine-rich repeat 807..830 CDD:275380 7/22 (32%)
LRR 20 830..851 8/20 (40%)
leucine-rich repeat 831..852 CDD:275380 8/20 (40%)
PCC 836..>1017 CDD:188093 29/189 (15%)
EGF 1006..1033 CDD:394967 5/28 (18%)
EGF_CA 1051..1086 CDD:238011 8/67 (12%)
EGF_CA 1089..1125 CDD:238011 8/43 (19%)
LamG 1196..1329 CDD:214598 28/149 (19%)
Blue background indicates that the domain is not in the aligned region.

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