DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and Slit2

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001278156.1 Gene:Slit2 / 20563 MGIID:1315205 Length:1542 Species:Mus musculus


Alignment Length:1622 Identity:324/1622 - (19%)
Similarity:535/1622 - (32%) Gaps:576/1622 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 QQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIW 213
            ::|.:....:.|:.:....||..||.|.|..:.|      ..||..||...:.||||.|:.||:.
Mouse    58 ERLDLNGNNITRITKIDFAGLRHLRVLQLMENRI------STIERGAFQDLKELERLRLNRNNLQ 116

  Fly   214 SLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLD 278
            ..|:.:|...::|..|::|||::|.:....||.                             ::|
Mouse   117 LFPELLFLGTAKLYRLDLSENQIQAIPRKAFRG-----------------------------AVD 152

  Fly   279 LEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNK------- 336
            ::.|.:.:|....:....|..||.|.||::|||.|:.::..:.:.:..|:...|.||.       
Mouse   153 IKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRLHSNNLYCDCHL 217

  Fly   337 ----------------------------------------------------------------- 336
                                                                             
Mouse   218 AWLSDWLRQRPRVGLYTQCMGPSHLRGHNVAEVQKREFVCSDEEEGHQSFMAPSCSVLHCPAACT 282

  Fly   337 ------------IVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITS- 388
                        :..:||.|    .:.|.|:.|:.|||.|:.|..||...:|:.||||.|||:. 
Mouse   283 CSNNIVDCRGKGLTEIPTNL----PETITEIRLEQNSIRVIPPGAFSPYKKLRRLDLSNNQISEL 343

  Fly   389 ---------------------TWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLR 432
                                 |.:.|:.|.||..|.||.|:.||:..|..:.|.||:.|.:|:|.
Mouse   344 APDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDAFQDLHNLNLLSLY 408

  Fly   433 HNQLENIAADTFAPMNNLHTLLLSHN------KLKYLDAY------ALNGLYVLSLLSLDNNALI 485
            .|:|:.:|..||:.:..:.|:.|:.|      .||:|..|      ..:|....|...|.|..:.
Mouse   409 DNKLQTVAKGTFSALRAIQTMHLAQNPFICDCHLKWLADYLHTNPIETSGARCTSPRRLANKRIG 473

  Fly   486 GVHPDAFRNCSALQDLNLNGNQ---------------------------------LKTVPLALRN 517
            .:....|| |||.:...:.|.:                                 |..:|..:  
Mouse   474 QIKSKKFR-CSAKEQYFIPGTEDYRSKLSGDCFADLACPEKCRCEGTTVDCSNQRLNKIPDHI-- 535

  Fly   518 MRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVV 582
            .::...:.|..|..||:|.:..                       |:.||.|:.:|.:.|:|..:
Mouse   536 PQYTAELRLNNNEFTVLEATGI-----------------------FKKLPQLRKINFSNNKITDI 577

  Fly   583 EPGAFEMTSSIQAVRLDGNELNDI-NGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKN 646
            |.||||..|.:..:.|..|.|.:: :.:|..:.|                      |:.|.|..|
Mouse   578 EEGAFEGASGVNEILLTSNRLENVQHKMFKGLES----------------------LKTLMLRSN 620

  Fly   647 RLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTR 711
            |:|.:.|    ||.:.|                   .|:.||.|.||.||||.|..|....:|:.
Mouse   621 RISCVGN----DSFIGL-------------------GSVRLLSLYDNQITTVAPGAFDSLHSLST 662

  Fly   712 VDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNI----DWLQKINHITSRQYPRIM 772
            ::|.|                             |||.|:|::    :||::...:|..  ||  
Mouse   663 LNLLA-----------------------------NPFNCNCHLAWLGEWLRRKRIVTGN--PR-- 694

  Fly   773 DLETIYCKLLNNRERAY----IPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCF 833
                  |      ::.|    ||:.:...:.|.|....         :.::|.....||:.|||.
Mouse   695 ------C------QKPYFLKEIPIQDVAIQDFTCDDGN---------DDNSCSPLSRCPSECTCL 738

  Fly   834 HDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFV----ELAGHSFLGRKNLAVLYANNSN 894
                  ..:|.||......:|:.:|.|.:|||:|||.|.    ||:.:     |:|.::..:|:.
Mouse   739 ------DTVVRCSNKGLKVLPKGIPKDVTELYLDGNQFTLVPKELSNY-----KHLTLIDLSNNR 792

  Fly   895 VAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEV 959
            ::.:.|.:||.:.:||.|.|..|.:..:....|..|::||.|.|..|.|:.:..|:|..|..|..
Mouse   793 ISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHGNDISVVPEGAFNDLSALSH 857

  Fly   960 LRLDGN------RLMHFEVW------------------------------------------QLS 976
            |.:..|      .:.....|                                          |..
Mouse   858 LAIGANPLYCDCNMQWLSDWVKSEYKEPGIARCAGPGEMADKLLLTTPSKKFTCQGPVDITIQAK 922

  Fly   977 ANPYLVEISLADNQ--------WSCECGYLARFRNYLGQSSEKIIDASRVSCIYN----NATSVL 1029
            .||.|......|..        :.|.|.|     .:.||..:..|.|    ||.|    ..|..|
Mouse   923 CNPCLSNPCKNDGTCNNDPVDFYRCTCPY-----GFKGQDCDVPIHA----CISNPCKHGGTCHL 978

  Fly  1030 RE-------------------------------KNGTKCTLRDGVAHY----------MHTNEIE 1053
            :|                               :|.:.|.  ||:.:|          .:.||:|
Mouse   979 KEGENAGFWCTCADGFEGENCEVNIDDCEDNDCENNSTCV--DGINNYTCLCPPEYTAANLNEVE 1041

  Fly  1054 -GLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMN----FCYKSPRFVDQLDKERPN 1113
             |.|....:..||               .:|....|.:.|::.    .|..:|.::         
Mouse  1042 KGELCEEKLDFCA---------------QDLNPCQHDSKCILTPKGFKCDCTPGYI--------- 1082

  Fly  1114 DAYFAYSLQDEHFVNQILAQTLENDIGYRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNF 1178
                     .||.           ||.:..|...:..| .|:.|||:       ..:..|..:.:
Mouse  1083 ---------GEHC-----------DIDFDDCQDNKCKN-GAHCTDAV-------NGYTCVCPEGY 1119

  Fly  1179 --LYNEWS------------RFEYKSALHELVKRRKRVVFILYGDLPQRDIDMDMRHYLRTSTCI 1229
              |:.|:|            .|:.::....:::..:.:...|.|.|.::...:...:::...:.:
Mouse  1120 SGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIIRINEPICQCLPGYLGEKCEKLVSVNFVNKESYL 1184

  Fly  1230 EWDDKKFWQKLRLALPLPNGRGNNNKRVVSGCLSGRTP----SVNMY--ATSHEYQAGNGGVIPP 1288
            :....|...:..:.|.:.....       ||.|..:..    :|.:|  .....|..|:    .|
Mouse  1185 QIPSAKVRPQTNITLQIATDED-------SGILLYKGDKDHIAVELYRGRVRASYDTGS----HP 1238

  Fly  1289 PSARYA--DCGSNNY-----ATINECAAAGGGRGYKPIPTSASAAAAACKFNTMN---------Q 1337
            .||.|:  .....|:     .|::...:.....|...:.|:.|      |.:|:|         .
Mouse  1239 ASAIYSVETINDGNFHIVELLTLDSSLSLSVDGGSPKVITNLS------KQSTLNFDSPLYVGGM 1297

  Fly  1338 LSKKQQRDLSVA-GMAKTLEHQHHHNHQANRRSQHEYAVP---SYLPSAAPAYDSV---DYAKQQ 1395
            ..|.....|..| |...|..|....|...|...|....:|   ..||...|.:..|   ...:..
Mouse  1298 PGKNNVASLRQAPGQNGTSFHGCIRNLYINSELQDFRKMPMQTGILPGCEPCHKKVCAHGMCQPS 1362

  Fly  1396 IRNNANCECVN--LGTAKRAAGKNPASGLPSSFSSNFVPPGGASYNCKKSCSCI-GDDELLC 1454
            .::...|||..  :|........:|..| ........:|....||:||    |: |...:||
Mouse  1363 SQSGFTCECEEGWMGPLCDQRTNDPCLG-NKCVHGTCLPINAFSYSCK----CLEGHGGVLC 1419

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 4/21 (19%)
LRR_8 171..236 CDD:290566 23/64 (36%)
leucine-rich repeat 172..201 CDD:275380 9/28 (32%)
leucine-rich repeat 202..278 CDD:275380 17/75 (23%)
leucine-rich repeat 229..249 CDD:275380 7/19 (37%)
LRR_RI 278..468 CDD:238064 68/307 (22%)
leucine-rich repeat 279..302 CDD:275380 4/22 (18%)
LRR_8 301..386 CDD:290566 31/168 (18%)
leucine-rich repeat 303..326 CDD:275380 7/22 (32%)
leucine-rich repeat 327..350 CDD:275380 7/106 (7%)
LRR 350..729 CDD:227223 108/446 (24%)
leucine-rich repeat 352..375 CDD:275380 10/22 (45%)
leucine-rich repeat 376..401 CDD:275380 13/46 (28%)
LRR_RI <401..626 CDD:238064 60/270 (22%)
leucine-rich repeat 402..425 CDD:275380 10/22 (45%)
leucine-rich repeat 426..449 CDD:275380 8/22 (36%)
leucine-rich repeat 450..473 CDD:275380 8/34 (24%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
leucine-rich repeat 498..518 CDD:275380 3/52 (6%)
leucine-rich repeat 521..544 CDD:275380 5/22 (23%)
leucine-rich repeat 545..566 CDD:275380 1/20 (5%)
leucine-rich repeat 569..592 CDD:275380 9/22 (41%)
leucine-rich repeat 593..615 CDD:275380 4/22 (18%)
leucine-rich repeat 616..637 CDD:275380 0/20 (0%)
leucine-rich repeat 638..662 CDD:275380 9/23 (39%)
leucine-rich repeat 663..684 CDD:275380 1/20 (5%)
leucine-rich repeat 685..708 CDD:275380 11/22 (50%)
leucine-rich repeat 709..728 CDD:275380 3/18 (17%)
LRR_8 883..943 CDD:290566 18/59 (31%)
leucine-rich repeat 885..908 CDD:275380 5/22 (23%)
leucine-rich repeat 909..932 CDD:275380 7/22 (32%)
LRR_8 932..990 CDD:290566 18/105 (17%)
leucine-rich repeat 933..956 CDD:275380 9/22 (41%)
TIR 1114..1247 CDD:214587 20/146 (14%)
Slit2NP_001278156.1 LRRNT 27..58 CDD:214470 324/1622 (20%)
leucine-rich repeat 38..56 CDD:275380
LRR_8 55..115 CDD:290566 19/62 (31%)
LRR 1 56..77 2/18 (11%)
leucine-rich repeat 57..80 CDD:275380 4/21 (19%)
LRR_4 58..95 CDD:289563 9/42 (21%)
LRR 2 80..101 9/26 (35%)
LRR_RI <81..214 CDD:238064 43/167 (26%)
leucine-rich repeat 81..104 CDD:275380 9/28 (32%)
LRR 3 104..125 9/20 (45%)
leucine-rich repeat 105..128 CDD:275380 9/22 (41%)
LRR 4 128..149 7/20 (35%)
leucine-rich repeat 129..152 CDD:275380 8/51 (16%)
LRR 5 152..173 4/20 (20%)
leucine-rich repeat 153..176 CDD:275380 4/22 (18%)
LRR_8 154..211 CDD:290566 16/56 (29%)
LRR 6 176..197 7/20 (35%)
leucine-rich repeat 177..200 CDD:275380 7/22 (32%)
leucine-rich repeat 201..329 CDD:275380 17/131 (13%)
LRRCT 209..258 CDD:214507 1/48 (2%)
LRRNT 276..308 CDD:214470 4/35 (11%)
LRR 7 305..326 9/20 (45%)
LRR_8 307..364 CDD:290566 17/56 (30%)
LRR_4 328..368 CDD:289563 9/39 (23%)
LRR 8 329..350 8/20 (40%)
leucine-rich repeat 330..353 CDD:275380 8/22 (36%)
LRR 9 353..374 3/20 (15%)
leucine-rich repeat 354..374 CDD:275380 3/19 (16%)
LRR 10 377..398 8/20 (40%)
leucine-rich repeat 378..401 CDD:275380 10/22 (45%)
LRR_8 384..436 CDD:290566 17/51 (33%)
LRR_RI <394..650 CDD:238064 72/326 (22%)
LRR 11 401..422 8/20 (40%)
leucine-rich repeat 402..423 CDD:275380 8/20 (40%)
leucine-rich repeat 426..527 CDD:275380 17/101 (17%)
TPKR_C2 434..>464 CDD:301599 6/29 (21%)
LRR 12 538..559 5/43 (12%)
LRR_4 541..579 CDD:289563 12/60 (20%)
leucine-rich repeat 541..563 CDD:275380 7/44 (16%)
LRR_8 562..622 CDD:290566 20/81 (25%)
LRR 13 563..584 8/20 (40%)
leucine-rich repeat 564..587 CDD:275380 9/22 (41%)
LRR 14 587..608 4/20 (20%)
leucine-rich repeat 588..611 CDD:275380 4/22 (18%)
LRR_8 611..670 CDD:290566 27/132 (20%)
LRR 15 611..632 10/46 (22%)
leucine-rich repeat 612..635 CDD:275380 10/45 (22%)
LRR 16 635..656 12/20 (60%)
leucine-rich repeat 636..659 CDD:275380 11/22 (50%)
leucine-rich repeat 660..751 CDD:275380 28/150 (19%)
LRRCT 668..717 CDD:214507 15/64 (23%)
LRRNT 731..762 CDD:214470 11/36 (31%)
leucine-rich repeat 752..782 CDD:275380 12/34 (35%)
LRR 17 759..781 10/26 (38%)
LRR_8 781..841 CDD:290566 18/59 (31%)
LRR_4 781..822 CDD:289563 11/40 (28%)
LRR 18 782..803 4/20 (20%)
leucine-rich repeat 783..806 CDD:275380 5/22 (23%)
LRR 19 806..827 6/20 (30%)
leucine-rich repeat 807..830 CDD:275380 7/22 (32%)
LRR 20 830..851 8/20 (40%)
leucine-rich repeat 831..852 CDD:275380 8/20 (40%)
LRRCT 863..912 CDD:214507 2/48 (4%)
EGF_CA 924..958 CDD:238011 9/38 (24%)
EGF_CA <968..1000 CDD:238011 4/31 (13%)
EGF_CA 1002..1033 CDD:214542 5/32 (16%)
EGF_CA 1051..1086 CDD:238011 8/67 (12%)
EGF_CA 1089..1125 CDD:238011 8/43 (19%)
LamG 1196..1329 CDD:214598 28/149 (19%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45836
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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