DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and Slit1

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_056563.2 Gene:Slit1 / 20562 MGIID:1315203 Length:1531 Species:Mus musculus


Alignment Length:1079 Identity:238/1079 - (22%)
Similarity:368/1079 - (34%) Gaps:385/1079 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    86 AAGLDQPEIAL------------------TCNLRTVNSEFDTTNFSVIPAEHTIALHILCNDEIM 132
            ::||.:||:.|                  ||...||:..  .|....||.      :|..|.|  
Mouse    10 SSGLSRPELWLLLWAAAWRLGATACPALCTCTGTTVDCH--GTGLQAIPK------NIPRNTE-- 64

  Fly   133 AKSRLEAQSFAHLVRLQQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFS 197
                             :|.:....:.|:.:....||:|||.|.|..:.|      ..:|..||.
Mouse    65 -----------------RLELNGNNITRIHKNDFAGLKQLRVLQLMENQI------GAVERGAFD 106

  Fly   198 VTRRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTT 262
            ..:.||||.|:.|.:..||:.:|.....||.|::|||.||.|....||        |:|      
Mouse   107 DMKELERLRLNRNQLQVLPELLFQNNQALSRLDLSENFLQAVPRKAFR--------GAT------ 157

  Fly   263 ESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNL 327
                           ||:.|.:..|....:....|..||.|.||::|||.|:.|...:.:.:..|
Mouse   158 ---------------DLKNLQLDKNRISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKL 207

  Fly   328 QILNLSSNK-------------------------------------------------------- 336
            :...|.||.                                                        
Mouse   208 RTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKGEFSCSGQGEAAGA 272

  Fly   337 ---------------------------IVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLD 374
                                       :.|:|..|    .:.:.|:.|:.|.|..:.|..||...
Mouse   273 PACTLSSGSCPAMCSCSSGIVDCRGKGLTAIPANL----PETMTEIRLELNGIKSIPPGAFSPYR 333

  Fly   375 QLQALDLSMNQITS----------------------TWIDKNTFVGLIRLVLLNLSHNKLTKLEP 417
            :|:.:|||.|||..                      |.:.:..|.||..|.||.|:.||:..:.|
Mouse   334 KLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRP 398

  Fly   418 EIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHN------KLKYL-DAYALN-----G 470
            :.|.||..|.:|:|..|:::::|..||..:..:.||.|:.|      .||:| |....|     |
Mouse   399 DAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFLRTNPIETTG 463

  Fly   471 LYVLSLLSLDNNALIGVHPDAFRNCSA--------LQDLNLNG---------------------N 506
            ....|...|.|..:..:....|| |||        .:|.:||.                     :
Mouse   464 ARCASPRRLANKRIGQIKSKKFR-CSAKEQYFIPGTEDYHLNSECTSDVACPHKCRCEASVVECS 527

  Fly   507 QLKTVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQI 571
            .||...:..|..:....:.|..|.|:::|.:         ||              |:.|.:|:.
Mouse   528 SLKLSKIPERIPQSTTELRLNNNEISILEAT---------GL--------------FKKLSHLKK 569

  Fly   572 LNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDI-NGLFSNMPSLLWLNISDNRLESFDYGHVP 635
            :||:.|:::.:|.|.||..:|:..:.|..|:|..| :|:|..:..|..|.:.:||:..       
Mouse   570 INLSNNKVSEIEDGTFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISC------- 627

  Fly   636 STLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDP 700
                   :|.:..:.|.|                               :.||.|.||.|||:.|
Mouse   628 -------IHNDSFTGLRN-------------------------------VRLLSLYDNHITTISP 654

  Fly   701 DTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNI----DWLQKIN 761
            ..|.....|:.::|.|                             |||.|:|::    |||:|..
Mouse   655 GAFDTLQALSTLNLLA-----------------------------NPFNCNCHLSWLGDWLRKRK 690

  Fly   762 HITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTC 826
            .:|..  ||..:.:.:          ..|||.:.....|.|....         |...|.....|
Mouse   691 IVTGN--PRCQNPDFL----------RQIPLQDVAFPDFRCEEGQ---------EEVGCLPRPQC 734

  Fly   827 PTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYAN 891
            |..|.|.      ..:|.||......:|:.:|.:.:|||:|||.|..:.|.              
Mouse   735 PQECACL------DTVVRCSNKHLQALPKGIPKNVTELYLDGNQFTLVPGQ-------------- 779

  Fly   892 NSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRK 956
                       .|..|.|.::.|.:|.|.||..:.|.|:..|..|.|..|.:..|...:||.||.
Mouse   780 -----------LSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRS 833

  Fly   957 LEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCEC 995
            |.:|.|.||.:...:....:....|..:::..|...|:|
Mouse   834 LRLLSLHGNDVSTLQEGIFADVTSLSHLAIGANPLYCDC 872

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 4/22 (18%)
LRR_8 171..236 CDD:290566 24/64 (38%)
leucine-rich repeat 172..201 CDD:275380 8/28 (29%)
leucine-rich repeat 202..278 CDD:275380 22/75 (29%)
leucine-rich repeat 229..249 CDD:275380 9/19 (47%)
LRR_RI 278..468 CDD:238064 65/301 (22%)
leucine-rich repeat 279..302 CDD:275380 5/22 (23%)
LRR_8 301..386 CDD:290566 28/167 (17%)
leucine-rich repeat 303..326 CDD:275380 8/22 (36%)
leucine-rich repeat 327..350 CDD:275380 7/105 (7%)
LRR 350..729 CDD:227223 102/442 (23%)
leucine-rich repeat 352..375 CDD:275380 7/22 (32%)
leucine-rich repeat 376..401 CDD:275380 11/46 (24%)
LRR_RI <401..626 CDD:238064 67/266 (25%)
leucine-rich repeat 402..425 CDD:275380 10/22 (45%)
leucine-rich repeat 426..449 CDD:275380 7/22 (32%)
leucine-rich repeat 450..473 CDD:275380 10/34 (29%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
leucine-rich repeat 498..518 CDD:275380 6/40 (15%)
leucine-rich repeat 521..544 CDD:275380 4/22 (18%)
leucine-rich repeat 545..566 CDD:275380 3/20 (15%)
leucine-rich repeat 569..592 CDD:275380 8/22 (36%)
leucine-rich repeat 593..615 CDD:275380 6/22 (27%)
leucine-rich repeat 616..637 CDD:275380 4/20 (20%)
leucine-rich repeat 638..662 CDD:275380 3/23 (13%)
leucine-rich repeat 663..684 CDD:275380 0/20 (0%)
leucine-rich repeat 685..708 CDD:275380 10/22 (45%)
leucine-rich repeat 709..728 CDD:275380 3/18 (17%)
LRR_8 883..943 CDD:290566 14/59 (24%)
leucine-rich repeat 885..908 CDD:275380 1/22 (5%)
leucine-rich repeat 909..932 CDD:275380 8/22 (36%)
LRR_8 932..990 CDD:290566 15/57 (26%)
leucine-rich repeat 933..956 CDD:275380 8/22 (36%)
TIR 1114..1247 CDD:214587
Slit1NP_056563.2 LRRNT 33..64 CDD:214470 9/38 (24%)
leucine-rich repeat 43..62 CDD:275380 6/26 (23%)
LRR <62..>219 CDD:227223 56/210 (27%)
LRR 1 62..83 4/39 (10%)
leucine-rich repeat 63..86 CDD:275380 5/41 (12%)
LRR 2 86..107 9/26 (35%)
leucine-rich repeat 87..110 CDD:275380 8/28 (29%)
LRR 3 110..131 9/20 (45%)
leucine-rich repeat 111..134 CDD:275380 9/22 (41%)
LRR 4 134..155 11/28 (39%)
leucine-rich repeat 135..158 CDD:275380 13/51 (25%)
LRR 5 158..179 5/20 (25%)
LRR_8 159..217 CDD:338972 18/57 (32%)
leucine-rich repeat 159..182 CDD:275380 5/22 (23%)
LRR 6 182..203 8/20 (40%)
leucine-rich repeat 183..206 CDD:275380 8/22 (36%)
PCC 188..>328 CDD:188093 17/143 (12%)
leucine-rich repeat 207..334 CDD:275380 14/130 (11%)
LRR 7 310..331 6/20 (30%)
internalin_A 311..>682 CDD:380193 107/468 (23%)
LRR 8 334..355 7/20 (35%)
leucine-rich repeat 335..358 CDD:275380 7/22 (32%)
LRR 9 358..379 2/20 (10%)
leucine-rich repeat 359..379 CDD:275380 2/19 (11%)
LRR 10 382..403 8/20 (40%)
leucine-rich repeat 383..406 CDD:275380 10/22 (45%)
LRR 11 406..427 7/20 (35%)
leucine-rich repeat 407..428 CDD:275380 7/20 (35%)
leucine-rich repeat 431..528 CDD:275380 21/97 (22%)
leucine-rich repeat 529..566 CDD:275380 11/59 (19%)
LRR 12 541..562 6/43 (14%)
LRR 13 566..587 7/20 (35%)
leucine-rich repeat 567..590 CDD:275380 8/22 (36%)
LRR 14 590..611 7/20 (35%)
leucine-rich repeat 591..614 CDD:275380 6/22 (27%)
LRR 15 614..635 5/34 (15%)
leucine-rich repeat 615..638 CDD:275380 6/36 (17%)
LRR 16 638..659 11/51 (22%)
leucine-rich repeat 639..660 CDD:275380 10/20 (50%)
PCC 644..>730 CDD:188093 30/135 (22%)
leucine-rich repeat 663..754 CDD:275380 29/146 (20%)
LRRNT 733..765 CDD:214470 9/37 (24%)
leucine-rich repeat 755..785 CDD:275380 11/54 (20%)
LRR_8 762..820 CDD:338972 22/82 (27%)
LRR 17 762..783 9/45 (20%)
LRR 18 785..806 7/20 (35%)
leucine-rich repeat 786..809 CDD:275380 8/22 (36%)
LRR 19 809..830 6/20 (30%)
leucine-rich repeat 810..830 CDD:275380 6/19 (32%)
LRR 20 833..854 5/20 (25%)
leucine-rich repeat 834..857 CDD:275380 5/22 (23%)
PCC 842..>1002 CDD:188093 5/31 (16%)
EGF_CA 1005..1041 CDD:238011
EGF_CA 1044..1080 CDD:238011
EGF_CA 1085..1119 CDD:238011
LamG 1186..1319 CDD:214598
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45836
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
22.010

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