DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and LGI3

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_644807.1 Gene:LGI3 / 203190 HGNCID:18711 Length:548 Species:Homo sapiens


Alignment Length:507 Identity:100/507 - (19%)
Similarity:166/507 - (32%) Gaps:158/507 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   826 CPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYA 890
            ||.:|:|..|..:..:        ...:||.:|.:...|.:....|.|:...:|.....|..|..
Human    39 CPPSCSCTRDTAFCVD--------SKAVPRNLPSEVISLTLVNAAFSEIQDGAFSHLPLLQFLLL 95

  Fly   891 NNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLR 955
            |::....|.:..|:||..|..|.:|:|.|.:|....|..|::|..|.|.:|.:.::....|:.|.
Human    96 NSNKFTLIGDNAFTGLSHLQYLFIENNDIWALSKFTFRGLKSLTHLSLANNNLQTLPRDIFRPLD 160

  Fly   956 KLEVLRLDGN------RLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKIID 1014
            .|..|.|.||      ::.....|....|..:..|         .|....||:.:..|.    :.
Human   161 ILNDLDLRGNSLNCDCKVKWLVEWLAHTNTTVAPI---------YCASPPRFQEHKVQD----LP 212

  Fly  1015 ASRVSCIYNN----------ATS------------VLREKNGTKCT----------LRD----GV 1043
            .....||..:          |.|            .|.:...:.||          |||    ..
Human   213 LREFDCITTDFVLYQTLAFPAVSAEPFLYSSDLYLALAQPGVSACTILKWDYVERQLRDYDRIPA 277

  Fly  1044 AHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGLFCYRHELKIWAHSTNCLMNFCYKSPRF--VDQ 1106
            ...:|...       ::|.:..:|....|..|.:.|.     |..:|.          ||  :..
Human   278 PSAVHCKP-------MVVDSQLYVVVAQLFGGSYIYH-----WDPNTT----------RFTRLQD 320

  Fly  1107 LDKER---PNDA---------YFAY---------SLQDEHFVNQILAQTLENDIGYRLCLH--YR 1148
            :|.:|   |||.         |||.         ||...|          :|.......||  :|
Human   321 IDPQRVRKPNDLEAFRIDGDWYFAVADSSKAGATSLYRWH----------QNGFYSHQALHPWHR 375

  Fly  1149 DVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGDLPQ- 1212
            |.::.      .::.....:..|...|:..:..:|||.:.:              |:..|::.| 
Human   376 DTDLE------FVDGEGKPRLIVSSSSQAPVIYQWSRTQKQ--------------FVAQGEVTQV 420

  Fly  1213 ------------RDIDMDMRHYLRTSTCIEWDDKKFWQKLRLALPLPNGRGN 1252
                        ||..:.:..|:..|..:.|:..:|.:.  .|||   .||:
Human   421 PDAQAVKHFRAGRDSYLCLSRYIGDSKILRWEGTRFSEV--QALP---SRGS 467

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064
leucine-rich repeat 279..302 CDD:275380
LRR_8 301..386 CDD:290566
leucine-rich repeat 303..326 CDD:275380
leucine-rich repeat 327..350 CDD:275380
LRR 350..729 CDD:227223
leucine-rich repeat 352..375 CDD:275380
leucine-rich repeat 376..401 CDD:275380
LRR_RI <401..626 CDD:238064
leucine-rich repeat 402..425 CDD:275380
leucine-rich repeat 426..449 CDD:275380
leucine-rich repeat 450..473 CDD:275380
leucine-rich repeat 474..497 CDD:275380
leucine-rich repeat 498..518 CDD:275380
leucine-rich repeat 521..544 CDD:275380
leucine-rich repeat 545..566 CDD:275380
leucine-rich repeat 569..592 CDD:275380
leucine-rich repeat 593..615 CDD:275380
leucine-rich repeat 616..637 CDD:275380
leucine-rich repeat 638..662 CDD:275380
leucine-rich repeat 663..684 CDD:275380
leucine-rich repeat 685..708 CDD:275380
leucine-rich repeat 709..728 CDD:275380
LRR_8 883..943 CDD:290566 19/59 (32%)
leucine-rich repeat 885..908 CDD:275380 7/22 (32%)
leucine-rich repeat 909..932 CDD:275380 8/22 (36%)
LRR_8 932..990 CDD:290566 14/63 (22%)
leucine-rich repeat 933..956 CDD:275380 6/22 (27%)
TIR 1114..1247 CDD:214587 29/165 (18%)
LGI3NP_644807.1 LRR_8 68..124 CDD:290566 15/55 (27%)
leucine-rich repeat 68..89 CDD:275378 4/20 (20%)
LRR 1 89..110 5/20 (25%)
leucine-rich repeat 90..113 CDD:275378 7/22 (32%)
LRR_8 112..172 CDD:290566 19/59 (32%)
LRR_4 113..152 CDD:289563 12/38 (32%)
LRR 2 113..134 7/20 (35%)
leucine-rich repeat 114..137 CDD:275378 8/22 (36%)
LRR 135..158 CDD:197688 6/22 (27%)
LRR 3 137..158 5/20 (25%)
leucine-rich repeat 138..161 CDD:275378 6/22 (27%)
leucine-rich repeat 162..174 CDD:275378 5/11 (45%)
LRRCT 170..218 CDD:214507 8/60 (13%)
EAR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075 222..264 5/41 (12%)
EPTP 222..263 CDD:281697 5/40 (13%)
EAR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075 268..310 10/53 (19%)
EPTP 268..309 CDD:281697 9/52 (17%)
EAR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075 314..361 13/56 (23%)
EPTP 314..359 CDD:281697 12/44 (27%)
EAR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075 363..406 7/48 (15%)
EPTP 363..405 CDD:281697 6/47 (13%)
EAR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075 410..453 8/56 (14%)
EPTP 410..452 CDD:281697 7/55 (13%)
EAR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075 455..497 6/18 (33%)
EPTP 455..496 CDD:281697 6/18 (33%)
EAR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00075 501..543
EPTP 501..541 CDD:281697
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

Return to query results.
Submit another query.