DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and let-4

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_510425.2 Gene:let-4 / 181554 WormBaseID:WBGene00002282 Length:773 Species:Caenorhabditis elegans


Alignment Length:408 Identity:117/408 - (28%)
Similarity:209/408 - (51%) Gaps:43/408 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   397 VGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNN-LHTLLLSHNKL 460
            ||||:.:.:|.:  :|.:|.|..||.|: ::.|:|..|:::.|....||.:|. |..::|:||.:
 Worm    61 VGLIQSLTMNQA--ELVELPPNFFSGLF-IRRLDLSQNKIKKIDDAAFAGINPVLEEVVLNHNLI 122

  Fly   461 KYLDAYALNGLYVLSLLSLDNNALIGV-HPDAFRNCSALQDLNLNGNQLKTVPLA-LRNMRH-LR 522
            :.:.|.||.||..|..|.|.||:::.: ..:.|.|.:.|.|:||..|::.::..: .:|::: ::
 Worm   123 EKVPAAALAGLPNLLRLDLSNNSIVEIQEQEIFPNLNKLYDINLGSNKIFSIHTSTFQNVKNSIQ 187

  Fly   523 TVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAF 587
            |::||.|.:|.:..||.:||..|..|.|..|.:|.:....|.:||.|.:||||.|:|..:...||
 Worm   188 TINLGHNNMTAVPSSAIRGLKQLQSLHLHKNRIEQLDALNFLNLPVLNLLNLAGNQIHELNRQAF 252

  Fly   588 EMTSSIQAVRLDGNELNDINGL-FSNMPSLLWLNISDNRLESFDYGHVPST-------LQWLDLH 644
            ....|::.:.|.||::..:... |.....|..|::::|.:     |.:|:.       |:.|.|.
 Worm   253 LNVPSLRYLYLSGNKITKLTAYQFQTFEQLEMLDLTNNEI-----GAIPANSLSGLKQLRQLYLA 312

  Fly   645 KNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGP---SSIPNSIELLFLNDNLITTVDPDTFMHK 706
            .|::|::|:....:|.:.:  |.:|.|:|:.:..   |.:||..::.| .||.|.|::.:.|...
 Worm   313 HNKISNISSNAFTNSSIVV--LVLSSNELKTLTAGIISGLPNLQQVSF-RDNQIKTINRNAFYDA 374

  Fly   707 TNLTRVDLYANQIT----TLDIKSLRILPV-WEHRALPE------------FYIGGNPFTCDCNI 754
            .:|..:||..||:|    |..:..|.:|.| .....||:            ..:..||..|..|:
 Worm   375 ASLVMLDLAKNQLTEIAPTTFLAQLNLLLVDLSENKLPKTPYSAFNSRVGTVLLKENPLVCTENL 439

  Fly   755 DWLQKINHITSRQYPRIM 772
            ..||:...:..|..|.|:
 Worm   440 HMLQQGTGVYVRDSPDII 457

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 23/71 (32%)
leucine-rich repeat 279..302 CDD:275380
LRR_8 301..386 CDD:290566
leucine-rich repeat 303..326 CDD:275380
leucine-rich repeat 327..350 CDD:275380
LRR 350..729 CDD:227223 104/350 (30%)
leucine-rich repeat 352..375 CDD:275380
leucine-rich repeat 376..401 CDD:275380 3/3 (100%)
LRR_RI <401..626 CDD:238064 70/229 (31%)
leucine-rich repeat 402..425 CDD:275380 7/22 (32%)
leucine-rich repeat 426..449 CDD:275380 6/22 (27%)
leucine-rich repeat 450..473 CDD:275380 9/22 (41%)
leucine-rich repeat 474..497 CDD:275380 7/23 (30%)
leucine-rich repeat 498..518 CDD:275380 5/20 (25%)
leucine-rich repeat 521..544 CDD:275380 9/22 (41%)
leucine-rich repeat 545..566 CDD:275380 6/20 (30%)
leucine-rich repeat 569..592 CDD:275380 9/22 (41%)
leucine-rich repeat 593..615 CDD:275380 4/22 (18%)
leucine-rich repeat 616..637 CDD:275380 5/20 (25%)
leucine-rich repeat 638..662 CDD:275380 7/23 (30%)
leucine-rich repeat 663..684 CDD:275380 6/23 (26%)
leucine-rich repeat 685..708 CDD:275380 6/22 (27%)
leucine-rich repeat 709..728 CDD:275380 7/22 (32%)
LRR_8 883..943 CDD:290566
leucine-rich repeat 885..908 CDD:275380
leucine-rich repeat 909..932 CDD:275380
LRR_8 932..990 CDD:290566
leucine-rich repeat 933..956 CDD:275380
TIR 1114..1247 CDD:214587
let-4NP_510425.2 leucine-rich repeat 66..86 CDD:275380 6/21 (29%)
LRR_RI <71..275 CDD:238064 65/206 (32%)
LRR_8 88..146 CDD:290566 21/57 (37%)
leucine-rich repeat 88..111 CDD:275380 7/22 (32%)
leucine-rich repeat 112..135 CDD:275380 9/22 (41%)
leucine-rich repeat 136..160 CDD:275380 7/23 (30%)
LRR_8 156..220 CDD:290566 20/63 (32%)
leucine-rich repeat 161..184 CDD:275380 6/22 (27%)
leucine-rich repeat 186..209 CDD:275380 9/22 (41%)
leucine-rich repeat 210..257 CDD:275380 17/46 (37%)
LRR_RI <250..411 CDD:238064 42/168 (25%)
LRR_8 256..316 CDD:290566 14/64 (22%)
leucine-rich repeat 258..281 CDD:275380 4/22 (18%)
leucine-rich repeat 282..305 CDD:275380 5/27 (19%)
leucine-rich repeat 306..328 CDD:275380 6/21 (29%)
LRR_8 327..387 CDD:290566 18/62 (29%)
leucine-rich repeat 329..350 CDD:275380 5/22 (23%)
leucine-rich repeat 353..400 CDD:275380 13/47 (28%)
leucine-rich repeat 356..376 CDD:275380 6/20 (30%)
leucine-rich repeat 401..419 CDD:275380 4/17 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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