Protein Alignment Toll-6 and pan-1

DIOPT Version :9

• Sequence 1: NP_001246765.1
• Gene: Toll-6 / 39663
• FlyBaseID: FBgn0036494
• Length: 1514
• Species: Drosophila melanogaster
• Sequence 2: NP_497925.1
• Gene: pan-1 / 175596
• WormBaseID: WBGene00003915
• Length: 594
• Species: Caenorhabditis elegans
• Alignment Length: 522
• Identity: 132/522 - (25%)
• Similarity: 230/522 - (44%)
• Gaps: 90/522 - (17%)

  Fly   265 AKKSSSSSTSCSLDL-----EYLDVSHNDFVVLPANG-FGTLRRLRVLSVNNNGISMIADKALSG 323
            |:.:.|..|...:|:     |..:.......:...|| |.|::.. .:...:..|:.:::. |:.
 Worm    13 ARIAISEETKSCIDIEKGFKEEFNAHKQPVCICADNGIFSTVKGF-TIECESASIASVSEN-LAS 75

  Fly   324 LKNLQI--LNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQI 386
            |...::  |.:..:.:..||.:||  :....::|.|:...:|.|.|..|      |:|..|..
 Worm    76 LNGTELGRLTIRDSTVNVLPQDLF--ENVFAKQVKLERCGLSTLQPNSF------QSLGGSAE-- 130

  Fly   387 TSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLH 451
                             ||:|..|::.|||..:|:.|.:|:.|:|..|:::.|....|..:..:.
 Worm   131 -----------------LLSLRENRIKKLEKGLFTGLKSLKTLDLAMNKIQEIDVGAFEELKKVE 178

  Fly   452 TLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLK----TVP 512
            .|||:.|.::.|.....:|:..|..|:|.|..|..:...|||..::|:.|.|:.|.|:    |:.
 Worm   179 ELLLNENDIRVLKTGTFDGMKNLKKLTLQNCNLEIIQKGAFRGLNSLEQLILSNNNLENIDWTIF 243

  Fly   513 LALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARN 577
            .||:|   ||.:|||.|.|:.:|..:|..|..|.   |..|.::::.....:|||:|.:....||
 Worm   244 SALKN---LRVLDLGSNKISNVEMKSFPKLEKLV---LNNNTIDSMKSIKLKDLPSLVVALFDRN 302

  Fly   578 RI-AVVEPGAFEMTSS--IQAVRLDGNELNDIN-GLFSNMPSLLWLNISDNRLESFDYGHVPSTL 638
            :| ::.:...|.:|.|  |:.:.|..|.|:.|: ..|.:.|:|:.|.:..|::|... .|.||
 Worm   303 KIESIGDMDMFGLTRSDRIETLSLARNNLSQISPKAFQHTPNLITLLLQYNQIEELS-SHSPS-- 364

  Fly   639 QWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDT- 702
               .:....|:||.         ||.||.:|.|.|..|....:|.|:..|.|:.|:|:.::...
 Worm   365 ---QVRTPFLASLK---------KLVTLQLSSNNLSVIRSDELPKSLSSLALDHNVISKIEARAL 417

  Fly   703 --------FMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCN--IDWL 757
                    ::|...|..  ||.....:...||:..:.|           ..||:.|.||  .:||
 Worm   418 EGMEIKRLYLHSNKLNY--LYQGTFDSFSPKSVEAVDV-----------SLNPWVCVCNDPKEWL 469

  Fly   758 QK 759
            .:
 Worm   470 PR 471

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	3/12 (25%)
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	43/197 (22%)
		leucine-rich repeat	279..302	CDD:275380	5/28 (18%)
		LRR_8	301..386	CDD:290566	17/86 (20%)
		leucine-rich repeat	303..326	CDD:275380	3/22 (14%)
		leucine-rich repeat	327..350	CDD:275380	5/24 (21%)
		LRR	350..729	CDD:227223	107/395 (27%)
		leucine-rich repeat	352..375	CDD:275380	6/22 (27%)
		leucine-rich repeat	376..401	CDD:275380	3/24 (13%)
		LRR_RI	<401..626	CDD:238064	71/232 (31%)
		leucine-rich repeat	402..425	CDD:275380	9/22 (41%)
		leucine-rich repeat	426..449	CDD:275380	6/22 (27%)
		leucine-rich repeat	450..473	CDD:275380	6/22 (27%)
		leucine-rich repeat	474..497	CDD:275380	8/22 (36%)
		leucine-rich repeat	498..518	CDD:275380	8/23 (35%)
		leucine-rich repeat	521..544	CDD:275380	10/22 (45%)
		leucine-rich repeat	545..566	CDD:275380	3/20 (15%)
		leucine-rich repeat	569..592	CDD:275380	6/23 (26%)
		leucine-rich repeat	593..615	CDD:275380	6/22 (27%)
		leucine-rich repeat	616..637	CDD:275380	6/20 (30%)
		leucine-rich repeat	638..662	CDD:275380	3/23 (13%)
		leucine-rich repeat	663..684	CDD:275380	8/20 (40%)
		leucine-rich repeat	685..708	CDD:275380	5/31 (16%)
		leucine-rich repeat	709..728	CDD:275380	5/18 (28%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
pan-1	NP_497925.1	leucine-rich repeat	130..152	CDD:275380	9/40 (23%)
		LRR_8	132..187	CDD:290566	18/54 (33%)
		leucine-rich repeat	153..176	CDD:275380	6/22 (27%)
		leucine-rich repeat	177..200	CDD:275380	6/22 (27%)
		LRR_8	199..259	CDD:290566	23/62 (37%)
		leucine-rich repeat	201..224	CDD:275380	8/22 (36%)
		LRR_RI	224..434	CDD:238064	65/230 (28%)
		leucine-rich repeat	225..248	CDD:275380	8/22 (36%)
		leucine-rich repeat	249..269	CDD:275380	9/19 (47%)
		LRR_8	268..355	CDD:290566	24/89 (27%)
		leucine-rich repeat	270..293	CDD:275380	6/25 (24%)
		leucine-rich repeat	294..320	CDD:275380	7/25 (28%)
		LRR_8	320..387	CDD:290566	23/81 (28%)
		leucine-rich repeat	321..344	CDD:275380	6/22 (27%)
		LRR_8	375..432	CDD:290566	15/65 (23%)
		leucine-rich repeat	377..398	CDD:275380	8/20 (40%)
		leucine-rich repeat	399..420	CDD:275380	4/20 (20%)
		leucine-rich repeat	423..442	CDD:275380	4/20 (20%)
		LRR_RI	80..326	CDD:238064	76/278 (27%)
		leucine-rich repeat	81..104	CDD:275380	5/24 (21%)
		leucine-rich repeat	105..128	CDD:275380	8/28 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910