DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and tol-1

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001020983.1 Gene:tol-1 / 171635 WormBaseID:WBGene00006593 Length:1221 Species:Caenorhabditis elegans


Alignment Length:1326 Identity:343/1326 - (25%)
Similarity:564/1326 - (42%) Gaps:249/1326 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 TAGAGGD--PSLYD-APDD---------CHF-------MPAAGLDQPEIALTCNLRTVNSEFDTT 110
            :|.|.||  |.... |||.         |.:       .|.|..:..::|   |:|::....|..
 Worm    20 SAAANGDECPKFCKCAPDPVQPTSKLLLCDYSSKNTTITPIASSNYDQVA---NIRSLFISCDNN 81

  Fly   111 NFSVIPAEHTIALHILCNDEIMAKSRLEAQSFAHLVRLQQLSIQYCKLGRLGRQVLDGLEQLRNL 175
            ||....|                       .|..|..|..|.|..|:......::.:.|..||.|
 Worm    82 NFQFPDA-----------------------YFKSLTALHHLRIVGCETTHFSVKLFEDLAALRRL 123

  Fly   176 TLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDV- 239
            .|  ..|...:.:||:..|......|||:..|:.:....||..:.|:|..|..||:|.|.|..: 
 Worm   124 EL--DQISTASTSFEMTEDVLMPLARLEKFSLTRSRNIELPQRLLCSLPHLQVLNISSNELPSLR 186

  Fly   240 -------NELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTS-CSLD-------LEYLDVSHN-- 287
                   .:|...|.|:.......:......:.::.|.:..| ..||       |:.||...|  
 Worm   187 REESCVAQQLLIVDLSRNRLTNIEQFLRGIPAIRQISVAYNSIAELDLSLATPFLQQLDAEANRI 251

  Fly   288 -DFVVLPANGFGTLRRLRVLSVN--NNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQA 349
             |...||    ||     |:.||  .|.:..:.| |::.|.:|..||:|.|:|.|          
 Worm   252 VDLTSLP----GT-----VVHVNLAGNALKRVPD-AVAELASLVALNVSRNEIEA---------- 296

  Fly   350 KIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITS---TWIDKNTFVGLIRLVLLNLSHNK 411
                    .|:|:       ||: .:|:.||.|.|::.|   .|:.|..    .|:..|:|.||.
 Worm   297 --------GNSSV-------FSS-PELEMLDASYNKLDSLPVEWLQKCE----KRIAHLHLEHNS 341

  Fly   412 LTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNN-LHTLLLSHNKLKYLDAYALNGLYVLS 475
            :.:|...:.::...||.|:|..||| .:..|...|.|: :..|.||:|.|:.|:..:|:||    
 Worm   342 IEQLTGGVLANATNLQTLDLSSNQL-RVFRDEVLPENSKIGNLRLSNNSLELLEPSSLSGL---- 401

  Fly   476 LLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMEDSAFK 540
                                 .|:.|:|:.|:|..||.|:..:..|:.|||..|.|..:......
 Worm   402 ---------------------KLESLDLSHNKLTEVPAAIGKVEQLKKVDLSHNRIAKVYQYVLN 445

  Fly   541 GLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELND 605
            .:..|:.:.|..|.|::|..:.|.|...|..|:::.|.|:::...||.....::.:.:..|::..
 Worm   446 KIKQLHTVDLSNNQLQSIGPYIFSDSSELHSLDVSNNEISLLFKDAFARCPKLRKISMKMNKIKS 510

  Fly   606 INGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSF 670
            ::...:....|..|::|.|.:....:..:|..|:.|:...|.::.|:......|...|:::.:|.
 Worm   511 LDEGLTEASGLRRLDVSHNEILVLKWSALPENLEILNADNNDINLLTAASMSPSTANLKSVSLSN 575

  Fly   671 NQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEH 735
            |.:..:....||||:|.|.:::|.:..:.......|:.|.|::|..|.:|.:..:|::::.. .|
 Worm   576 NGITIMNADQIPNSLESLDVSNNRLAKLGKTALAAKSQLRRLNLKGNLLTVVATESMKVVEA-VH 639

  Fly   736 RALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIM--DLETIYCKLLNNRERAYIPLIEAEPK 798
            ....|  |..||..|||.:.|:      .....|:::  |.||..|.  :..:...|.:.....|
 Worm   640 PLKVE--ISENPLICDCQMGWM------IGGAKPKVLIQDSETASCS--HAVDGHQIQIQSLSKK 694

  Fly   799 HFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECSGAAYSEMPRR------V 857
            ..||.||:.|...|.||::..|||:..||.||.||.|..::.|||.|.|.: |.:|:|      :
 Worm   695 DLLCPYKSVCEPECICCQYGNCDCKSVCPANCRCFRDDQFNINIVRCHGNS-SMVPKREFVVSEL 758

  Fly   858 PMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISL 922
            |:..:|:.:.|....:|..|||:||..|..|:.|.:.:..|....|..|..|..|.|.||.:|||
 Worm   759 PVSATEIILSGVTLPQLRTHSFIGRLRLQRLHINGTGLRSIQPKAFHTLPALKTLDLSDNSLISL 823

  Fly   923 EGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLA 987
            .|.||.....:.:|:|..|:.::::.|.|:.|..|:.|.|..|.|.  ::.|:..:..|.:|||:
 Worm   824 SGEEFLKCGEVSQLFLNGNRFSTLSRGIFEKLPNLKYLTLHNNSLE--DIPQVLHSTALSKISLS 886

  Fly   988 DNQWSCECG-----YLARFRN-------------YLGQSSEKIIDASRVSCIYN-------NATS 1027
            .|...|:|.     :|...|:             :.......::|..:|.|..|       |.|:
 Worm   887 SNPLRCDCSGGSQQHLHHRRDPKAHPFWEHNAAEWFSLHRHLVVDFPKVECWENVTKAFLTNDTT 951

  Fly  1028 V--------------------LREKNGTKCT----------LRDGVAHYMHTNEIEGLLPLLLVA 1062
            |                    ||:.|.|.|.          .::.:...:.|..|..||.:|::.
 Worm   952 VLSAYPPNMGNDVFVMPIEEFLRDYNSTICVPFSSGFFGQDPQNSILFVIITISIAVLLCVLVIL 1016

  Fly  1063 TCAFVAFFGLIFGLFCYRHEL----KIWAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQD 1123
            ..:|:.          ..|:.    :..|.|.||..: ...||..|..|...    |:.:||.:|
 Worm  1017 AISFIR----------KSHDAINQRRYKASSLNCSTS-AGSSPLPVPLLSYH----AFVSYSKKD 1066

  Fly  1124 EHFVNQILAQTLENDIGYRLCLHYRD-----VNINAYITDALIEAAESAKQFVLVLSKNFLYNEW 1183
            |..|...|.:.|| |..|:|||.:||     .|::| |:|.||...:|::..:|||:|:||.|||
 Worm  1067 EKMVIDQLCRPLE-DEDYQLCLLHRDGPTYCSNLHA-ISDELIAQMDSSQCLILVLTKHFLENEW 1129

  Fly  1184 SRFEYKSALHELV--KRRKRVVFILYGDLPQRDIDMDMRHYLRTSTCIEWDDKKFWQKLRLA--- 1243
            ...:.|:: |:|.  .|.|||:.:|...:....:|.::...||..|.||.....||..|..:   
 Worm  1130 KTLQIKTS-HQLFAKNRAKRVIAVLGDGVDANLLDDELGQILRKHTRIEMRSHLFWTLLHSSLPS 1193

  Fly  1244 -LPLPNGRGNNNKRVVSGCLSGRTPS 1268
             ||||:..|:::.::.|. :.|..||
 Worm  1194 RLPLPSNSGDDSSQLYSD-IYGIVPS 1218

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 5/22 (23%)
LRR_8 171..236 CDD:290566 21/64 (33%)
leucine-rich repeat 172..201 CDD:275380 8/28 (29%)
leucine-rich repeat 202..278 CDD:275380 18/84 (21%)
leucine-rich repeat 229..249 CDD:275380 7/27 (26%)
LRR_RI 278..468 CDD:238064 58/205 (28%)
leucine-rich repeat 279..302 CDD:275380 9/25 (36%)
LRR_8 301..386 CDD:290566 23/86 (27%)
leucine-rich repeat 303..326 CDD:275380 7/24 (29%)
leucine-rich repeat 327..350 CDD:275380 7/22 (32%)
LRR 350..729 CDD:227223 92/382 (24%)
leucine-rich repeat 352..375 CDD:275380 4/22 (18%)
leucine-rich repeat 376..401 CDD:275380 8/27 (30%)
LRR_RI <401..626 CDD:238064 57/225 (25%)
leucine-rich repeat 402..425 CDD:275380 5/22 (23%)
leucine-rich repeat 426..449 CDD:275380 9/22 (41%)
leucine-rich repeat 450..473 CDD:275380 9/22 (41%)
leucine-rich repeat 474..497 CDD:275380 0/22 (0%)
leucine-rich repeat 498..518 CDD:275380 8/19 (42%)
leucine-rich repeat 521..544 CDD:275380 6/22 (27%)
leucine-rich repeat 545..566 CDD:275380 6/20 (30%)
leucine-rich repeat 569..592 CDD:275380 6/22 (27%)
leucine-rich repeat 593..615 CDD:275380 1/21 (5%)
leucine-rich repeat 616..637 CDD:275380 5/20 (25%)
leucine-rich repeat 638..662 CDD:275380 5/23 (22%)
leucine-rich repeat 663..684 CDD:275380 5/20 (25%)
leucine-rich repeat 685..708 CDD:275380 4/22 (18%)
leucine-rich repeat 709..728 CDD:275380 6/18 (33%)
LRR_8 883..943 CDD:290566 20/59 (34%)
leucine-rich repeat 885..908 CDD:275380 6/22 (27%)
leucine-rich repeat 909..932 CDD:275380 11/22 (50%)
LRR_8 932..990 CDD:290566 16/57 (28%)
leucine-rich repeat 933..956 CDD:275380 6/22 (27%)
TIR 1114..1247 CDD:214587 51/143 (36%)
tol-1NP_001020983.1 leucine-rich repeat 71..95 CDD:275380 7/46 (15%)
leucine-rich repeat 96..119 CDD:275380 5/22 (23%)
leucine-rich repeat 120..171 CDD:275380 16/52 (31%)
leucine-rich repeat 172..195 CDD:275380 6/22 (27%)
leucine-rich repeat 196..283 CDD:275380 23/96 (24%)
leucine-rich repeat 219..240 CDD:275378 4/20 (20%)
leucine-rich repeat 241..258 CDD:275378 5/16 (31%)
LRR 265..600 CDD:227223 97/391 (25%)
leucine-rich repeat 287..306 CDD:275380 10/44 (23%)
leucine-rich repeat 307..331 CDD:275380 8/27 (30%)
leucine-rich repeat 332..355 CDD:275380 5/22 (23%)
leucine-rich repeat 356..379 CDD:275380 10/23 (43%)
leucine-rich repeat 380..395 CDD:275380 6/14 (43%)
leucine-rich repeat 403..425 CDD:275380 8/21 (38%)
leucine-rich repeat 426..449 CDD:275380 6/22 (27%)
leucine-rich repeat 450..473 CDD:275380 7/22 (32%)
leucine-rich repeat 474..497 CDD:275380 6/22 (27%)
leucine-rich repeat 498..520 CDD:275380 1/21 (5%)
leucine-rich repeat 543..567 CDD:275380 5/23 (22%)
leucine-rich repeat 568..589 CDD:275380 5/20 (25%)
leucine-rich repeat 590..613 CDD:275380 4/22 (18%)
leucine-rich repeat 614..633 CDD:275380 6/18 (33%)
leucine-rich repeat 763..785 CDD:275378 8/21 (38%)
LRR_8 785..844 CDD:338972 20/58 (34%)
leucine-rich repeat 786..809 CDD:275378 6/22 (27%)
LRR_9 <806..>890 CDD:373143 29/85 (34%)
leucine-rich repeat 810..833 CDD:275378 11/22 (50%)
leucine-rich repeat 834..857 CDD:275378 6/22 (27%)
leucine-rich repeat 858..879 CDD:275378 6/22 (27%)
leucine-rich repeat 880..892 CDD:275378 5/11 (45%)
TIR_2 1056..1194 CDD:390066 49/144 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 132 1.000 Domainoid score I3176
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 370 1.000 Inparanoid score I1230
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG28754
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm14097
orthoMCL 1 0.900 - - OOG6_104126
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R17065
SonicParanoid 1 1.000 - - X221
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.770

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