DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-6 and Cd180

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_032559.2	Gene:	Cd180 / 17079	MGIID:	1194924	Length:	661	Species:	Mus musculus

Alignment Length:	755	Identity:	162/755 - (21%)
Similarity:	282/755 - (37%)	Gaps:	199/755 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 APD-DCHFMPAAGL---------DQPEIALTCNLRTVNSEFDTTNFSVIPAEHTIALHILCND-E 130
            ||| .|.|:.|..|         ||     .|..:.||..::..|..:.....|:.....|.: .
Mouse     2 APDISCFFLVALFLASCRATTSSDQ-----KCIEKEVNKTYNCENLGLNEIPGTLPNSTECLEFS 61

  Fly   131 IMAKSRLEAQSFAHLVRLQQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADA 195
            ......::..:|:.|:.|..|.:..|:                        |.|      |..|.
Mouse    62 FNVLPTIQNTTFSRLINLTFLDLTRCQ------------------------IYW------IHEDT 96

  Fly   196 FSVTRRLERLDLSSNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTS 260
            |....||:.|.|::|.:..:.:........|..|...:..:..::.:...::            .
Mouse    97 FQSQHRLDTLVLTANPLIFMAETALSGPKALKHLFFIQTGISSIDFIPLHNQ------------K 149

  Fly   261 TTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLK 325
            |.||.               ||..:|...:.|| .||.| .:|:||...||.|..::.:.:|.|:
Mouse   150 TLESL---------------YLGSNHISSIKLP-KGFPT-EKLKVLDFQNNAIHYLSKEDMSSLQ 197

  Fly   326 ---NLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQAL--DLSMNQ 385
               ||. |||:.|.|..:  ||.|..:.:.|.          ||   |.....|..:  .|..:.
Mouse   198 QATNLS-LNLNGNDIAGI--ELGAFDSAVFQS----------LN---FGGTQNLLVIFKGLKNST 246

  Fly   386 ITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQI--LNLRHNQLENIAADTFAPMN 448
            |.|.|:  .||..:           ....:.|.:|..|..:.:  :||:.:...||:::||...:
Mouse   247 IQSLWL--GTFEDM-----------DDEDISPAVFEGLCEMSVESINLQKHYFFNISSNTFHCFS 298

  Fly   449 NLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGN--QLKTV 511
            .|..|.|:...|..|.: .|.||..|..|.|..|....:...:..|..:|..|::.||  :|:..
Mouse   299 GLQELDLTATHLSELPS-GLVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRLELG 362

  Fly   512 PLALRNMRHLRTVDLGENMITVME--DSAFKGLGNLYGLRLIGNYLENITMHT--FRDLPNLQIL 572
            ...|.|:.:||.:||..:.|...:  :...:.|.:|..|.|  :|.|.:::.|  |::.|.|::|
Mouse   363 TGCLENLENLRELDLSHDDIETSDCCNLQLRNLSHLQSLNL--SYNEPLSLKTEAFKECPQLELL 425

  Fly   573 NLARNRIAVVE-PGAFEMTSSIQAVRLDGNELNDING--LFSNMPSLLWLNISDNRLESFDYGHV 634
            :||..|:.|.: ...|:....::.:.| .:.|.||:.  ||..:|:|..||:..|.   |..|::
Mouse   426 DLAFTRLKVKDAQSPFQNLHLLKVLNL-SHSLLDISSEQLFDGLPALQHLNLQGNH---FPKGNI 486

  Fly   635 PSTLQWLDLHKNRLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVD 699
            ..|                                 |.||.:|      .:|:|.|:...::::|
Mouse   487 QKT---------------------------------NSLQTLG------RLEILVLSFCDLSSID 512

  Fly   700 PDTFMHKTNLTRVDLYANQITTLDIKSL--------------------RILPVWEHRALPEFYIG 744
            ...|.....:..|||..|::|:..|::|                    .:||:...:.  ...:.
Mouse   513 QHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIILPSLLPILSQQR--TINLR 575

  Fly   745 GNPFTCDCN----IDWLQKINHITSRQYPRIMDLETIYCK 780
            .||..|.|:    ::|.::       ...::.|.|...|:
Mouse   576 QNPLDCTCSNIYFLEWYKE-------NMQKLEDTEDTLCE 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380	3/22 (14%)
		LRR_8	171..236	CDD:290566	12/64 (19%)
		leucine-rich repeat	172..201	CDD:275380	5/28 (18%)
		leucine-rich repeat	202..278	CDD:275380	9/75 (12%)
		leucine-rich repeat	229..249	CDD:275380	1/19 (5%)
		LRR_RI	278..468	CDD:238064	51/196 (26%)
		leucine-rich repeat	279..302	CDD:275380	8/22 (36%)
		LRR_8	301..386	CDD:290566	24/89 (27%)
		leucine-rich repeat	303..326	CDD:275380	8/25 (32%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR	350..729	CDD:227223	91/411 (22%)
		leucine-rich repeat	352..375	CDD:275380	4/22 (18%)
		leucine-rich repeat	376..401	CDD:275380	7/26 (27%)
		LRR_RI	<401..626	CDD:238064	61/235 (26%)
		leucine-rich repeat	402..425	CDD:275380	3/22 (14%)
		leucine-rich repeat	426..449	CDD:275380	6/24 (25%)
		leucine-rich repeat	450..473	CDD:275380	8/22 (36%)
		leucine-rich repeat	474..497	CDD:275380	5/22 (23%)
		leucine-rich repeat	498..518	CDD:275380	6/21 (29%)
		leucine-rich repeat	521..544	CDD:275380	6/24 (25%)
		leucine-rich repeat	545..566	CDD:275380	7/22 (32%)
		leucine-rich repeat	569..592	CDD:275380	7/23 (30%)
		leucine-rich repeat	593..615	CDD:275380	6/23 (26%)
		leucine-rich repeat	616..637	CDD:275380	6/20 (30%)
		leucine-rich repeat	638..662	CDD:275380	0/23 (0%)
		leucine-rich repeat	663..684	CDD:275380	4/20 (20%)
		leucine-rich repeat	685..708	CDD:275380	5/22 (23%)
		leucine-rich repeat	709..728	CDD:275380	7/38 (18%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
Cd180	NP_032559.2	leucine-rich repeat	38..57	CDD:275380	2/18 (11%)
		LRR 1	54..75		2/20 (10%)
		leucine-rich repeat	58..78	CDD:275380	2/19 (11%)
		LRR 2	78..99		8/50 (16%)
		leucine-rich repeat	79..102	CDD:275380	8/52 (15%)
		LRR 3	102..123		5/20 (25%)
		leucine-rich repeat	103..126	CDD:275380	4/22 (18%)
		LRR 4	126..147		2/20 (10%)
		leucine-rich repeat	127..150	CDD:275380	2/34 (6%)
		LRR 5	150..171		9/36 (25%)
		leucine-rich repeat	151..174	CDD:275380	10/39 (26%)
		LRR 6	174..195		6/20 (30%)
		leucine-rich repeat	175..201	CDD:275380	8/25 (32%)
		LRR 7	201..221		10/22 (45%)
		leucine-rich repeat	224..275	CDD:275380	14/76 (18%)
		LRR 8	275..296		6/20 (30%)
		leucine-rich repeat	276..299	CDD:275380	6/22 (27%)
		LRR 9	299..321		7/22 (32%)
		leucine-rich repeat	300..322	CDD:275380	8/22 (36%)
		LRR_8	321..382	CDD:290566	16/60 (27%)
		LRR 10	322..343		4/20 (20%)
		leucine-rich repeat	323..346	CDD:275380	5/22 (23%)
		LRR_RI	345..>541	CDD:238064	57/240 (24%)
		LRR 11	346..366		5/19 (26%)
		leucine-rich repeat	347..371	CDD:275380	7/23 (30%)
		LRR_8	371..432	CDD:290566	18/62 (29%)
		LRR 12	371..391		5/19 (26%)
		leucine-rich repeat	372..397	CDD:275380	6/24 (25%)
		LRR 13	397..418		7/22 (32%)
		leucine-rich repeat	398..421	CDD:275380	7/24 (29%)
		LRR_8	420..481	CDD:290566	19/64 (30%)
		LRR 14	421..442		6/20 (30%)
		leucine-rich repeat	422..446	CDD:275380	7/23 (30%)
		LRR 15	446..466		5/20 (25%)
		leucine-rich repeat	447..470	CDD:275380	6/23 (26%)
		LRR 16	470..493		8/58 (14%)
		leucine-rich repeat	471..497	CDD:275380	11/67 (16%)
		LRR_8	497..555	CDD:290566	12/57 (21%)
		LRR 17	497..518		5/20 (25%)
		leucine-rich repeat	498..521	CDD:275380	5/22 (23%)
		LRR 18	521..544		7/22 (32%)
		leucine-rich repeat	522..545	CDD:275380	7/22 (32%)
		LRR 19	546..566		2/19 (11%)
		LRRCT	577..626	CDD:214507	8/39 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910