DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and Tlr7

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001277687.1	Gene:	Tlr7 / 170743	MGIID:	2176882	Length:	1053	Species:	Mus musculus

Alignment Length:	1279	Identity:	273/1279 - (21%)
Similarity:	458/1279 - (35%)	Gaps:	400/1279 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 LTCNLRTVNSEFDTTNFSVIPAEHTIALHILCNDEIMAKSRLEAQSFAHLVRLQQLSIQYCKLGR 160
            |.|.:: ||          ||..|.|   :.|.|:             ||.
Mouse    37 LPCEVK-VN----------IPEAHVI---VDCTDK-------------HLT-------------- 60

  Fly   161 LGRQVLDGL-EQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSN----------NIWS 214
               ::.:|: ....||||..::|  |:    |..|:|.....||.:||..|          |:.:
Mouse    61 ---EIPEGIPTNTTNLTLTINHI--PS----ISPDSFRRLNHLEEIDLRCNCVPVLLGSKANVCT 116

  Fly   215 ----LPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSC 275
                :....|..||:|.||.:..|:|.::.:    |........|.|:.:.....|::.:.
Mouse   117 KRLQIRPGSFSGLSDLKALYLDGNQLLEIPQ----DLPSSLHLLSLEANNIFSITKENLTE---- 173

  Fly   276 SLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADK-ALSGLKNLQILNLSSNKIVA 339
            .:::|.|.:..|.:...|.|                 :|...:| |...::||::|:|..|.:.|
Mouse   174 LVNIETLYLGQNCYYRNPCN-----------------VSYSIEKDAFLVMRNLKVLSLKDNNVTA 221

  Fly   340 LPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMN---------------QITST 389
            :||.|    ...:.|:||.||.|..:....|:||::||.||||.|               ..:..
Mouse   222 VPTTL----PPNLLELYLYNNIIKKIQENDFNNLNELQVLDLSGNCPRCYNVPYPCTPCENNSPL 282

  Fly   390 WIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHN----QLENIAADTFAPMNNL 450
            .|..|.|..|..|.:|.|..|.|..:.|..|.::..||.|:|..|    ::|......|.|  ||
Mouse   283 QIHDNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIEEAKFLHFLP--NL 345

  Fly   451 HTLLLSHNKLKY-LDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLA 514
            ..|..|.|   | |..|..:.....||.||:|..::.|....|:             :||...|:
Mouse   346 VELDFSFN---YELQVYHASITLPHSLSSLENLKILRVKGYVFK-------------ELKNSSLS 394

  Fly   515 -LRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENIT------------------- 559
             |..:..|..:|||.|.|.:.:.:.||...|   |:||...:..|:
Mouse   395 VLHKLPRLEVLDLGTNFIKIADLNIFKHFEN---LKLIDLSVNKISPSEESREVGFCPNAQTSVD 456

  Fly   560 ---------MHTFR-------------DLPNL-----------QILNLARNRIAVVEPGAFEMTS 591
                     :|.||             :.|:.           |.|:|:||.|..::|..|:..|
Mouse   457 RHGPQVLEALHYFRYDEYARSCRFKNKEPPSFLPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLS 521

  Fly   592 SIQAVRLDGNELND-INGLFSNMPSLLWLNISDNRLESFDYGHVP-STLQWLDLHKNRLSSL-SN 653
            .::.:.|.||.:.. :||      |.||                | ..|::||...|||..| |.
Mouse   522 FLKCLNLSGNTIGQTLNG------SELW----------------PLRELRYLDFSNNRLDLLYST 564

  Fly   654 RFGLDSELK-LQTLDVSFNQ--LQRIGPSSIPN------SIELLFLNDNLITTVDPDTFMHKTNL 709
            .|   .||: |:.||:|.|.  .|..|.:.:.|      .::.|.:|||
Mouse   565 AF---EELQSLEVLDLSSNSHYFQAEGITHMLNFTKKLRLLDKLMMNDN---------------- 610

  Fly   710 TRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDL 774
               |:..:...|::..|||||         ||                 :.||:
Mouse   611 ---DISTSASRTMESDSLRIL---------EF-----------------RGNHL----------- 635

  Fly   775 ETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWS 839
             .:..:..:||   |:.                                         |....::
Mouse   636 -DVLWRAGDNR---YLD-----------------------------------------FFKNLFN 655

  Fly   840 TNIVECSGAAYSEMPRRV----PMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYN 900
            ..:::.|..:.:.:|..|    |.:...|.:..|.............|:|.:|..:::.:..:..
Mouse   656 LEVLDISRNSLNSLPPEVFEGMPPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLTKVPE 720

  Fly   901 TTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSF--QMLRKLEVLRLD 963
            ...:..|.|..|.|:.|.|..|......:...||.|.:.||||..|...||  .:|..||:|.|.
Mouse   721 RLANCSKSLTTLILKHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLH 785

  Fly   964 GNRLM-----HFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEK---IIDASRVSC 1020
            .||.:     .:.||.:             |.......|||.....:|..:.|   :|.....:|
Mouse   786 HNRFLCNCDAVWFVWWV-------------NHTDVTIPYLATDVTCVGPGAHKGQSVISLDLYTC 837

  Fly  1021 IYNNATSVLREKNGTKCTLRDGVAHYMHTNEIEGLLPLLLVATCAFVAFFGLIFGLFCYRHELKI 1085
            ..:....:|                  .:..|..:|.|::|.|.:.:.|:.:.:..:.::.::|.
Mouse   838 ELDLTNLIL------------------FSVSISSVLFLMVVMTTSHLFFWDMWYIYYFWKAKIKG 884

  Fly  1086 WAHSTNCLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDE---HFVNQILAQTLEN--DIGYRLCL 1145
            :.|..:  |..||               ||:..|..::.   .:|.|.|...||:  :..:.|||
Mouse   885 YQHLQS--MESCY---------------DAFIVYDTKNSAVTEWVLQELVAKLEDPREKHFNLCL 932

  Fly  1146 HYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSALHELVKRRKRVVFILYGDL 1210
            ..||......:.:.|.::.:.:|:.|.|:::.:...|..:..:..:...|:..:..|:.:::.:.
Mouse   933 EERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFYLSHQRLLDEKVDVIILIFLEK 997

  Fly  1211 P-QRDIDMDMRHYLRTSTCIEWDDKK-----FWQKLRLALPLPN 1248
            | |:...:.:|..|..|:.:||....     |||.|:.||...|
Mouse   998 PLQKSKFLQLRKRLCRSSVLEWPANPQAHPYFWQCLKNALTTDN 1041

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380	1/23 (4%)
		LRR_8	171..236	CDD:290566	22/78 (28%)
		leucine-rich repeat	172..201	CDD:275380	9/28 (32%)
		leucine-rich repeat	202..278	CDD:275380	18/89 (20%)
		leucine-rich repeat	229..249	CDD:275380	4/19 (21%)
		LRR_RI	278..468	CDD:238064	60/210 (29%)
		leucine-rich repeat	279..302	CDD:275380	5/22 (23%)
		LRR_8	301..386	CDD:290566	28/100 (28%)
		leucine-rich repeat	303..326	CDD:275380	3/23 (13%)
		leucine-rich repeat	327..350	CDD:275380	8/22 (36%)
		LRR	350..729	CDD:227223	116/463 (25%)
		leucine-rich repeat	352..375	CDD:275380	9/22 (41%)
		leucine-rich repeat	376..401	CDD:275380	11/39 (28%)
		LRR_RI	<401..626	CDD:238064	68/283 (24%)
		leucine-rich repeat	402..425	CDD:275380	7/22 (32%)
		leucine-rich repeat	426..449	CDD:275380	8/26 (31%)
		leucine-rich repeat	450..473	CDD:275380	7/23 (30%)
		leucine-rich repeat	474..497	CDD:275380	7/22 (32%)
		leucine-rich repeat	498..518	CDD:275380	4/20 (20%)
		leucine-rich repeat	521..544	CDD:275380	8/22 (36%)
		leucine-rich repeat	545..566	CDD:275380	7/61 (11%)
		leucine-rich repeat	569..592	CDD:275380	8/33 (24%)
		leucine-rich repeat	593..615	CDD:275380	5/22 (23%)
		leucine-rich repeat	616..637	CDD:275380	3/21 (14%)
		leucine-rich repeat	638..662	CDD:275380	10/24 (42%)
		leucine-rich repeat	663..684	CDD:275380	8/28 (29%)
		leucine-rich repeat	685..708	CDD:275380	4/22 (18%)
		leucine-rich repeat	709..728	CDD:275380	3/18 (17%)
		LRR_8	883..943	CDD:290566	15/59 (25%)
		leucine-rich repeat	885..908	CDD:275380	2/22 (9%)
		leucine-rich repeat	909..932	CDD:275380	6/22 (27%)
		LRR_8	932..990	CDD:290566	19/64 (30%)
		leucine-rich repeat	933..956	CDD:275380	11/24 (46%)
		TIR	1114..1247	CDD:214587	33/143 (23%)
Tlr7	NP_001277687.1	PRK15370	<35..>246	CDD:185268	63/287 (22%)
		leucine-rich repeat	51..72	CDD:275380	6/53 (11%)
		leucine-rich repeat	73..93	CDD:275380	8/25 (32%)
		leucine-rich repeat	94..131	CDD:275380	8/36 (22%)
		leucine-rich repeat	132..155	CDD:275380	6/26 (23%)
		PLN00113	177..>789	CDD:215061	176/779 (23%)
		leucine-rich repeat	177..208	CDD:275380	8/47 (17%)
		leucine-rich repeat	209..229	CDD:275380	8/23 (35%)
		leucine-rich repeat	230..253	CDD:275380	9/22 (41%)
		leucine-rich repeat	254..294	CDD:275380	11/39 (28%)
		leucine-rich repeat	295..318	CDD:275380	7/22 (32%)
		leucine-rich repeat	319..344	CDD:275380	8/26 (31%)
		leucine-rich repeat	345..401	CDD:275380	18/71 (25%)
		leucine-rich repeat	402..425	CDD:275380	8/22 (36%)
		leucine-rich repeat	500..522	CDD:275380	8/21 (38%)
		leucine-rich repeat	523..547	CDD:275380	9/45 (20%)
		leucine-rich repeat	548..571	CDD:275380	11/25 (44%)
		leucine-rich repeat	572..601	CDD:275380	8/28 (29%)
		leucine-rich repeat	602..624	CDD:275380	6/40 (15%)
		leucine-rich repeat	625..655	CDD:275380	12/111 (11%)
		leucine-rich repeat	656..680	CDD:275380	4/23 (17%)
		leucine-rich repeat	681..704	CDD:275380	2/22 (9%)
		leucine-rich repeat	705..728	CDD:275380	2/22 (9%)
		leucine-rich repeat	753..778	CDD:275380	11/24 (46%)
		PCC	757..>841	CDD:188093	24/96 (25%)
		TIR	894..1039	CDD:214587	35/159 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG4641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D147327at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.780