DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and LGI4

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_644813.1	Gene:	LGI4 / 163175	HGNCID:	18712	Length:	537	Species:	Homo sapiens

Alignment Length:	487	Identity:	106/487 - (21%)
Similarity:	176/487 - (36%)	Gaps:	122/487 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   826 CPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYA 890
            ||..|:|..|...      |.|:  .::|.........|.:......:|...|||...:|.:|..
Human    27 CPLRCSCSKDSAL------CEGS--PDLPVSFSPTLLSLSLVRTGVTQLKAGSFLRIPSLHLLLF 83

  Fly   891 NNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLR 955
            .:::.:.|.:..|:||..|..|.:|||.|.|:..|....|.:|..|.|.:|.:.::....|:.|.
Human    84 TSNSFSVIEDDAFAGLSHLQYLFIEDNEIGSISKNALRGLRSLTHLSLANNHLETLPRFLFRGLD 148

  Fly   956 KLEVLRLDGN------RLMHFEVWQLSANPYL--------VEIS------LADNQWSCECGYLAR 1000
            .|..:.|.||      |::....|..:.|..:        ..:|      |....:.|....|:.
Human   149 TLTHVDLRGNPFQCDCRVLWLLQWMPTVNASVGTGACAGPASLSHMQLHHLDPKTFKCRAIELSW 213

  Fly  1001 FRNYLGQSSEKIIDASRVSCIYNNATS-VLREKNGTKCTLRD---GVAHYMHTNEIEGLLPLLLV 1061
            |:. :|:|:..:...|     |..... ||.:....:|.:..   .:..:....|    ||...|
Human   214 FQT-VGESALSVEPFS-----YQGEPHIVLAQPFAGRCLILSWDYSLQRFRPEEE----LPAASV 268

  Fly  1062 ATCAFVAFFGLIFG--LFCYRHEL----KIWAH--------STNCLMNFCYKSPRFVDQLDKERP 1112
            .:|.     .|:.|  ||.....|    ::||.        .|..|      :||.:     .||
Human   269 VSCK-----PLVLGPSLFVLAARLWGGSQLWARPSPGLRLAPTQTL------APRRL-----LRP 317

  Fly  1113 NDAYFAYSLQDEHFVNQILAQTLENDIGYRLCL----HYRDVNINAYITDALIEAAE-SAKQFVL 1172
            |||...:......||   :|...:......||.    .|...:::|:..|...||.| ..:..:|
Human   318 NDAELLWLEGQPCFV---VADASKAGSTTLLCRDGPGFYPHQSLHAWHRDTDAEALELDGRPHLL 379

  Fly  1173 VLS---KNFLYNEWS--RFEYKSALHELVKRRKRVVFILYGDLPQR-------------DIDMDM 1219
            :.|   :..|:: |:  |||.::                  |:|:.             |:.:.:
Human   380 LASASQRPVLFH-WTGGRFERRT------------------DIPEAEDVYATRHFQAGGDVFLCL 425

  Fly  1220 RHYLRTSTCIEWDDKKFWQKLRLALPLPNGRG 1251
            ..|:..|..:.||...|    ||...||: ||
Human   426 TRYIGDSMVMRWDGSMF----RLLQQLPS-RG 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380
		LRR	350..729	CDD:227223
		leucine-rich repeat	352..375	CDD:275380
		leucine-rich repeat	376..401	CDD:275380
		LRR_RI	<401..626	CDD:238064
		leucine-rich repeat	402..425	CDD:275380
		leucine-rich repeat	426..449	CDD:275380
		leucine-rich repeat	450..473	CDD:275380
		leucine-rich repeat	474..497	CDD:275380
		leucine-rich repeat	498..518	CDD:275380
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..566	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		leucine-rich repeat	593..615	CDD:275380
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566	19/59 (32%)
		leucine-rich repeat	885..908	CDD:275380	6/22 (27%)
		leucine-rich repeat	909..932	CDD:275380	9/22 (41%)
		LRR_8	932..990	CDD:290566	15/77 (19%)
		leucine-rich repeat	933..956	CDD:275380	6/22 (27%)
		TIR	1114..1247	CDD:214587	30/155 (19%)
LGI4	NP_644813.1	leucine-rich repeat	29..53	CDD:275380	6/31 (19%)
		LRR 1	53..74		4/20 (20%)
		leucine-rich repeat	54..77	CDD:275378	5/22 (23%)
		LRR_8	76..136	CDD:316378	19/59 (32%)
		LRR 2	77..98		4/20 (20%)
		leucine-rich repeat	78..101	CDD:275378	6/22 (27%)
		LRR 3	101..122		8/20 (40%)
		leucine-rich repeat	102..125	CDD:275378	9/22 (41%)
		LRR 4	125..146		5/20 (25%)
		leucine-rich repeat	126..149	CDD:275378	6/22 (27%)
		PCC	131..>206	CDD:188093	13/74 (18%)
		leucine-rich repeat	150..162	CDD:275378	4/11 (36%)
		leucine-rich repeat	167..205	CDD:275380	4/37 (11%)
		EAR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	210..252		9/47 (19%)
		EPTP	214..251	CDD:309018	8/42 (19%)
		EAR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	256..298		12/50 (24%)
		EAR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	302..349		14/60 (23%)
		EAR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	351..394		10/43 (23%)
		EPTP	351..392	CDD:309018	9/41 (22%)
		EAR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	396..439		9/60 (15%)
		EPTP	396..438	CDD:309018	8/59 (14%)
		EAR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	441..483		7/17 (41%)
		EAR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00075	487..532
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000