DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and CHADL

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	XP_011528235.1	Gene:	CHADL / 150356	HGNCID:	25165	Length:	830	Species:	Homo sapiens

Alignment Length:	841	Identity:	183/841 - (21%)
Similarity:	265/841 - (31%)	Gaps:	316/841 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 WSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKK---SSSSSTS 274
            ||..:.....||:|..|...|                   .||.::.:....|..   :|||...
Human    83 WSADNASHSALSQLPGLRAVE-------------------GGSCQAGTACPCAAPPGWTSSSRRH 128

  Fly   275 CSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVA 339
            ..| .:.||:..|...|:||..|..:..|..|.:.:..:.::|:.|..||..|.:|||:||.:..
Human   129 GGL-TQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRE 192

  Fly   340 LPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVL 404
            ||.|.. :....::.:.|:.|::..|.|..|..|..|..|:|:.|.:  .::....|.||:|:..
Human   193 LPQEAL-DGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNAL--VYLPAMAFQGLLRVRW 254

  Fly   405 LNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYL---DAY 466
            |.||||.|:.|.||..:.|..|:.|:|.||:|:.:.....:....|..|.|.||.|.|.   |..
Human   255 LRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGL 319

  Fly   467 ALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMI 531
            ||.|   |..|.||..||..:.|.||.:|..|..|:|.||||.|:|
Human   320 ALPG---LRELLLDGGALQALGPRAFAHCPRLHTLDLRGNQLDTLP------------------- 362

  Fly   532 TVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAV 596
                  ..:|.|.|..|||.||
Human   363 ------PLQGPGQLRRLRLQGN------------------------------------------- 378

  Fly   597 RLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDSEL 661
                             |  ||.......|           |:||...:.|......
Human   379 -----------------P--LWCGCQARPL-----------LEWLARARVRSDGACQ-------- 405

  Fly   662 KLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDIKS 726
                           ||..:..                                         ::
Human   406 ---------------GPRRLRG-----------------------------------------EA 414

  Fly   727 LRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQY----------PRIMDLETIYCKL 781
            |..|..|:.|               |..|..|:...:..|..          ||
Human   415 LDALRPWDLR---------------CPGDAAQEEEELEERAVAGPRAPPRGPPR----------- 453

  Fly   782 LNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQTWSTNIVECS 846
            ....|||..|                                  ||..|.|..:...|:    |.
Human   454 GPGEERAVAP----------------------------------CPRACVCVPESRHSS----CE 480

  Fly   847 GAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTFSGLKRLLI 911
            |.....:||..|.||..|.:..|:|..:...:|.|..:|..|:..:..:|.:.....:||.||:.
Human   481 GCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIY 545

  Fly   912 LHLEDNHI----------------ISLEGNEF-----------------HNLEN----------- 932
            |:|.||.:                :.||.|.|                 |..:|
Human   546 LYLSDNQLAGLSAAALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLG 610

  Fly   933 ----LRELYLQSNKIASIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADN 989
                ||.:||..|:|..::.|:....|:||.|.||.|:|.......|...|.|:|:.|:.|
Human   611 RTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGN 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566	7/22 (32%)
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	13/67 (19%)
		leucine-rich repeat	229..249	CDD:275380	2/19 (11%)
		LRR_RI	278..468	CDD:238064	60/192 (31%)
		leucine-rich repeat	279..302	CDD:275380	7/22 (32%)
		LRR_8	301..386	CDD:290566	25/84 (30%)
		leucine-rich repeat	303..326	CDD:275380	6/22 (27%)
		leucine-rich repeat	327..350	CDD:275380	9/22 (41%)
		LRR	350..729	CDD:227223	79/381 (21%)
		leucine-rich repeat	352..375	CDD:275380	6/22 (27%)
		leucine-rich repeat	376..401	CDD:275380	7/24 (29%)
		LRR_RI	<401..626	CDD:238064	58/227 (26%)
		leucine-rich repeat	402..425	CDD:275380	10/22 (45%)
		leucine-rich repeat	426..449	CDD:275380	6/22 (27%)
		leucine-rich repeat	450..473	CDD:275380	11/25 (44%)
		leucine-rich repeat	474..497	CDD:275380	10/22 (45%)
		leucine-rich repeat	498..518	CDD:275380	9/19 (47%)
		leucine-rich repeat	521..544	CDD:275380	1/22 (5%)
		leucine-rich repeat	545..566	CDD:275380	6/20 (30%)
		leucine-rich repeat	569..592	CDD:275380	0/22 (0%)
		leucine-rich repeat	593..615	CDD:275380	0/21 (0%)
		leucine-rich repeat	616..637	CDD:275380	3/20 (15%)
		leucine-rich repeat	638..662	CDD:275380	4/23 (17%)
		leucine-rich repeat	663..684	CDD:275380	2/20 (10%)
		leucine-rich repeat	685..708	CDD:275380	0/22 (0%)
		leucine-rich repeat	709..728	CDD:275380	0/18 (0%)
		LRR_8	883..943	CDD:290566	22/107 (21%)
		leucine-rich repeat	885..908	CDD:275380	5/22 (23%)
		leucine-rich repeat	909..932	CDD:275380	10/55 (18%)
		LRR_8	932..990	CDD:290566	22/73 (30%)
		leucine-rich repeat	933..956	CDD:275380	7/22 (32%)
		TIR	1114..1247	CDD:214587
CHADL	XP_011528235.1	leucine-rich repeat	132..155	CDD:275380	7/22 (32%)
		LRR_RI	<133..358	CDD:238064	78/230 (34%)
		LRR_8	133..214	CDD:290566	24/81 (30%)
		leucine-rich repeat	156..179	CDD:275380	6/22 (27%)
		leucine-rich repeat	180..203	CDD:275380	9/23 (39%)
		leucine-rich repeat	204..227	CDD:275380	6/22 (27%)
		LRR_8	228..286	CDD:290566	23/59 (39%)
		leucine-rich repeat	228..251	CDD:275380	7/24 (29%)
		leucine-rich repeat	252..275	CDD:275380	10/22 (45%)
		leucine-rich repeat	276..299	CDD:275380	6/22 (27%)
		leucine-rich repeat	300..323	CDD:275380	10/22 (45%)
		LRR_8	322..380	CDD:290566	29/147 (20%)
		leucine-rich repeat	324..347	CDD:275380	10/22 (45%)
		LRR_4	346..>380	CDD:289563	18/120 (15%)
		LRRNT	463..497	CDD:214470	13/71 (18%)
		leucine-rich repeat	478..494	CDD:275380	5/19 (26%)
		LRR_RI	492..671	CDD:238064	45/178 (25%)
		leucine-rich repeat	495..518	CDD:275380	6/22 (27%)
		LRR_8	518..577	CDD:290566	14/58 (24%)
		leucine-rich repeat	519..542	CDD:275380	5/22 (23%)
		leucine-rich repeat	543..566	CDD:275380	5/22 (23%)
		LRR_8	565..625	CDD:290566	11/59 (19%)
		leucine-rich repeat	567..590	CDD:275380	4/22 (18%)
		leucine-rich repeat	591..614	CDD:275380	2/22 (9%)
		leucine-rich repeat	615..638	CDD:275380	7/22 (32%)
		LRR_8	637..698	CDD:290566	14/35 (40%)
		leucine-rich repeat	639..662	CDD:275380	8/22 (36%)
		leucine-rich repeat	663..687	CDD:275380	4/9 (44%)
		LRR_8	686..745	CDD:290566
		leucine-rich repeat	688..712	CDD:275380
		LRR_4	711..>744	CDD:289563
		LRRCT	743..791	CDD:214507
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	171	1.000	Inparanoid score	I4103
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.960