DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and Tlr3

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001344245.1 Gene:Tlr3 / 142980 MGIID:2156367 Length:905 Species:Mus musculus


Alignment Length:1074 Identity:240/1074 - (22%)
Similarity:406/1074 - (37%) Gaps:284/1074 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   270 SSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSS 334
            ||:..|::.....|.||.....:|                        |...|   |:.:|||:.
Mouse    24 SSTNQCTVRYNVADCSHLKLTHIP------------------------DDLPS---NITVLNLTH 61

  Fly   335 NKIVALPTELFA--EQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFV 397
            |::..||...|.  .|..|:...:   ||||.|.|:|...|..|:.|:|..|:::.  |...|||
Mouse    62 NQLRRLPPTNFTRYSQLAILDAGF---NSISKLEPELCQILPLLKVLNLQHNELSQ--ISDQTFV 121

  Fly   398 GLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKY 462
            ....|..|:|..|.:.|::...|.:...|..|:|.||.|.:....|...:.||..|||:.||:..
Mouse   122 FCTNLTELDLMSNSIHKIKSNPFKNQKNLIKLDLSHNGLSSTKLGTGVQLENLQELLLAKNKILA 186

  Fly   463 LDAYALNGLYVLSL--LSLDNNALIGVHPDAFRNCSALQDLNLNGNQLK---TVPLA--LRNMRH 520
            |.:..|..|...||  |.|.:|.|....|..|:....|..|.||..||.   |..|.  |.| ..
Mouse   187 LRSEELEFLGNSSLRKLDLSSNPLKEFSPGCFQTIGKLFALLLNNAQLNPHLTEKLCWELSN-TS 250

  Fly   521 LRTVDLGENMITVMEDSAFKGL--GNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVE 583
            ::.:.|..|.:....:|.|.||  .||..|.|..|.|.::...:|..||:|:.|:|..|.|..:.
Mouse   251 IQNLSLANNQLLATSESTFSGLKWTNLTQLDLSYNNLHDVGNGSFSYLPSLRYLSLEYNNIQRLS 315

  Fly   584 PGAFEMTSSI-----------QAVRLDGN-ELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPS 636
            |.:|...|::           |:|.|..: .::|.:  |..:..|.:||:.||        ::||
Mouse   316 PRSFYGLSNLRYLSLKRAFTKQSVSLASHPNIDDFS--FQWLKYLEYLNMDDN--------NIPS 370

  Fly   637 TLQWLDLHKNRLSSLSNRF-GLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDP 700
            |             .||.| ||.| ||..:|..:|..||.:                        
Mouse   371 T-------------KSNTFTGLVS-LKYLSLSKTFTSLQTL------------------------ 397

  Fly   701 DTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITS 765
                  ||.|.|.|..:.:.||::....|..:                 .:....||.::     
Mouse   398 ------TNETFVSLAHSPLLTLNLTKNHISKI-----------------ANGTFSWLGQL----- 434

  Fly   766 RQYPRIMD--LETIYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEMTCPT 828
                ||:|  |..|..||.....|....:.|     ...:|..:                     
Mouse   435 ----RILDLGLNEIEQKLSGQEWRGLRNIFE-----IYLSYNKY--------------------- 469

  Fly   829 NCTCFHDQTWSTNIVECSGAAYSEMP-------RRVPMDTSELYIDGNNFVELAGHSFLGRKNLA 886
                          ::.|.::::.:|       |||.:..          |:::...|...:||.
Mouse   470 --------------LQLSTSSFALVPSLQRLMLRRVALKN----------VDISPSPFRPLRNLT 510

  Fly   887 VLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISL--------EGNEFHNLENLRELYLQSNKI 943
            :|..:|:|:|:|......||:.|.||..:.|::..|        ..|....|.:|..|.|:||.:
Mouse   511 ILDLSNNNIANINEDLLEGLENLEILDFQHNNLARLWKRANPGGPVNFLKGLSHLHILNLESNGL 575

  Fly   944 ASIANGSFQMLRKLEVLRLDGNRLMHFEVW-----------QLSAN------------PY--LVE 983
            ..|..|.|:.|.:|:.:.|..|.|...|.:           .|..|            |:  |..
Mouse   576 DEIPVGVFKNLFELKSINLGLNNLNKLEPFIFDDQTSLRSLNLQKNLITSVEKDVFGPPFQNLNS 640

  Fly   984 ISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTLRDGVAHY-- 1046
            :.:..|.:.|.|..::.|.|::.|:...|   |.:|..|                |.:...||  
Mouse   641 LDMRFNPFDCTCESISWFVNWINQTHTNI---SELSTHY----------------LCNTPHHYYG 686

  Fly  1047 -----MHTNEIEGLLP---LLLVATCAFVAFFGLIFGLFCYRHELKI---WAHSTNCLMNFCYKS 1100
                 ..|:..:...|   |.:::|...:.|  ::..|..:....:|   |..|.:.::.|    
Mouse   687 FPLKLFDTSSCKDSAPFELLFIISTSMLLVF--ILVVLLIHIEGWRISFYWNVSVHRILGF---- 745

  Fly  1101 PRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLENDIGYRLCLHYRDVNINAYITDALIEAAE 1165
             :.:|...::....||..::.:|..:|.:..:...|.|...:.||..||........:|::.:.:
Mouse   746 -KEIDTQAEQFEYTAYIIHAHKDRDWVWEHFSPMEEQDQSLKFCLEERDFEAGVLGLEAIVNSIK 809

  Fly  1166 SAKQFVLVLSKNFLYNE-WSRFEYKSALHELVKRR-KRVVFILYGDLPQRDID--MDMRHYLRTS 1226
            .:::.:.|::.:.|.:. ..||:...|:.:.:::. ..::.|...::|...::  :.:|..:..|
Mouse   810 RSRKIIFVITHHLLKDPLCRRFKVHHAVQQAIEQNLDSIILIFLQNIPDYKLNHALCLRRGMFKS 874

  Fly  1227 TCI-EWDDKK-----FWQKLRLALPLPNGRGNNN 1254
            .|| .|..:|     |..||::||      |:.|
Mouse   875 HCILNWPVQKERINAFHHKLQVAL------GSRN 902

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380 3/7 (43%)
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 53/191 (28%)
leucine-rich repeat 279..302 CDD:275380 4/22 (18%)
LRR_8 301..386 CDD:290566 24/86 (28%)
leucine-rich repeat 303..326 CDD:275380 2/22 (9%)
leucine-rich repeat 327..350 CDD:275380 8/24 (33%)
LRR 350..729 CDD:227223 113/400 (28%)
leucine-rich repeat 352..375 CDD:275380 8/22 (36%)
leucine-rich repeat 376..401 CDD:275380 8/24 (33%)
LRR_RI <401..626 CDD:238064 74/245 (30%)
leucine-rich repeat 402..425 CDD:275380 6/22 (27%)
leucine-rich repeat 426..449 CDD:275380 7/22 (32%)
leucine-rich repeat 450..473 CDD:275380 9/22 (41%)
leucine-rich repeat 474..497 CDD:275380 8/24 (33%)
leucine-rich repeat 498..518 CDD:275380 9/24 (38%)
leucine-rich repeat 521..544 CDD:275380 6/24 (25%)
leucine-rich repeat 545..566 CDD:275380 6/20 (30%)
leucine-rich repeat 569..592 CDD:275380 7/22 (32%)
leucine-rich repeat 593..615 CDD:275380 5/33 (15%)
leucine-rich repeat 616..637 CDD:275380 6/20 (30%)
leucine-rich repeat 638..662 CDD:275380 6/24 (25%)
leucine-rich repeat 663..684 CDD:275380 4/20 (20%)
leucine-rich repeat 685..708 CDD:275380 0/22 (0%)
leucine-rich repeat 709..728 CDD:275380 5/18 (28%)
LRR_8 883..943 CDD:290566 21/67 (31%)
leucine-rich repeat 885..908 CDD:275380 8/22 (36%)
leucine-rich repeat 909..932 CDD:275380 7/30 (23%)
LRR_8 932..990 CDD:290566 18/82 (22%)
leucine-rich repeat 933..956 CDD:275380 9/22 (41%)
TIR 1114..1247 CDD:214587 29/142 (20%)
Tlr3NP_001344245.1 leucine-rich repeat 37..53 CDD:275380 6/42 (14%)
LRR 1 53..74 8/20 (40%)
leucine-rich repeat 54..77 CDD:275380 7/22 (32%)
PLN00113 70..>543 CDD:215061 148/608 (24%)
LRR 2 77..98 9/23 (39%)
leucine-rich repeat 78..101 CDD:275380 9/25 (36%)
LRR 3 101..122 7/22 (32%)
leucine-rich repeat 102..125 CDD:275380 8/24 (33%)
LRR 4 125..146 6/20 (30%)
leucine-rich repeat 126..149 CDD:275380 6/22 (27%)
LRR 5 149..170 7/20 (35%)
leucine-rich repeat 150..199 CDD:275380 17/48 (35%)
LRR 6 173..196 9/22 (41%)
LRR 7 199..220 8/20 (40%)
leucine-rich repeat 200..250 CDD:275380 17/50 (34%)
LRR 8 250..271 4/20 (20%)
leucine-rich repeat 251..276 CDD:275380 6/24 (25%)
LRR 9 276..297 7/20 (35%)
leucine-rich repeat 277..300 CDD:275380 7/22 (32%)
LRR 10 300..321 7/20 (35%)
leucine-rich repeat 301..324 CDD:275380 7/22 (32%)
LRR 11 324..345 3/20 (15%)
leucine-rich repeat 325..381 CDD:275380 18/78 (23%)
LRR 12 357..378 11/41 (27%)
LRR 13 381..401 9/50 (18%)
leucine-rich repeat 382..433 CDD:275380 16/97 (16%)
LRR 14 409..430 3/37 (8%)
LRR 15 433..454 7/29 (24%)
leucine-rich repeat 434..458 CDD:275380 8/32 (25%)
LRR 16 458..479 3/60 (5%)
leucine-rich repeat 459..482 CDD:275380 3/62 (5%)
LRR 17 482..502 4/29 (14%)
leucine-rich repeat 483..508 CDD:275380 5/34 (15%)
PPP1R42 503..>649 CDD:411060 36/145 (25%)
LRR 18 508..529 7/20 (35%)
leucine-rich repeat 509..532 CDD:275380 8/22 (36%)
LRR 19 532..553 5/20 (25%)
leucine-rich repeat 533..564 CDD:275380 7/30 (23%)
LRR 20 564..585 8/20 (40%)
leucine-rich repeat 565..586 CDD:275380 8/20 (40%)
LRR 21 588..609 5/20 (25%)
leucine-rich repeat 589..610 CDD:275378 5/20 (25%)
LRR 22 612..633 2/20 (10%)
leucine-rich repeat 613..637 CDD:275380 3/23 (13%)
LRRCT 646..698 CDD:214507 14/70 (20%)
Tlr3_TMD 699..731 CDD:407816 5/33 (15%)
TIR 756..901 CDD:214587 30/150 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG4641
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D147327at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
43.780

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