DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and LRRC15

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001128529.2	Gene:	LRRC15 / 131578	HGNCID:	20818	Length:	587	Species:	Homo sapiens

Alignment Length:	454	Identity:	128/454 - (28%)
Similarity:	212/454 - (46%)	Gaps:	90/454 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   336 KIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLI 400
            :|||:||.|           .....|:.:||..:                   |.::::.|:.:.
Human    49 RIVAVPTPL-----------PWNAMSLQILNTHI-------------------TELNESPFLNIS 83

  Fly   401 RLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDA 465
            .|:.|.:..|:|:::.|..|.:|.:|:.|:|.:|:|:.:....|..:::|.:||||
Human    84 ALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLS--------- 139

  Fly   466 YALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVP-LALRNMRHLRTVDLGEN 529
                           :|.|:.:.|..|..||.|::|.|:||.|:.:| .|..::..|..::||:|
Human   140 ---------------SNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKN 189

  Fly   530 MITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQ 594
            .:|.:....|:.||||..|||..|.|.:|.|.||..|.|||.|.|.:|:|.::.||.|....::|
Human   190 SLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQ 254

  Fly   595 AVRLDGNELNDI-NGLFSNMPSLLWLNISDNRLESFD---YGHVPSTLQWLDLHKNRLSSL-SNR 654
            .:.|..|.::.: ..:|..:|.|..|.:..|.|:...   :|.:|: |:.|.|:.|.:||| .|.
Human   255 RLYLSNNHISQLPPSVFMQLPQLNRLTLFGNSLKELSPGIFGPMPN-LRELWLYDNHISSLPDNV 318

  Fly   655 FGLDSELK-LQTLDVSFNQLQRIGPSSIPNSIEL--LFLNDNLITTVDPDTFMHKTNLTRVDLYA 716
            |   |.|: ||.|.:|.||:..|.|.:.....||  |.|:.|.:..:|.:.|....||..:.|..
Human   319 F---SNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQN 380

  Fly   717 NQI----------------TTLDIKSLRILP--VWEHRA-LPEFYIGGNPFTCDCNI----DWL 757
            |::                ..|....|..||  :::|.. |.|..:..||:.||.:|    :||
Human   381 NRLRQLPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWL 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	29/131 (22%)
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566	9/49 (18%)
		leucine-rich repeat	303..326	CDD:275380
		leucine-rich repeat	327..350	CDD:275380	6/13 (46%)
		LRR	350..729	CDD:227223	110/403 (27%)
		leucine-rich repeat	352..375	CDD:275380	3/22 (14%)
		leucine-rich repeat	376..401	CDD:275380	2/24 (8%)
		LRR_RI	<401..626	CDD:238064	70/226 (31%)
		leucine-rich repeat	402..425	CDD:275380	7/22 (32%)
		leucine-rich repeat	426..449	CDD:275380	6/22 (27%)
		leucine-rich repeat	450..473	CDD:275380	5/22 (23%)
		leucine-rich repeat	474..497	CDD:275380	5/22 (23%)
		leucine-rich repeat	498..518	CDD:275380	8/20 (40%)
		leucine-rich repeat	521..544	CDD:275380	7/22 (32%)
		leucine-rich repeat	545..566	CDD:275380	10/20 (50%)
		leucine-rich repeat	569..592	CDD:275380	9/22 (41%)
		leucine-rich repeat	593..615	CDD:275380	4/22 (18%)
		leucine-rich repeat	616..637	CDD:275380	6/23 (26%)
		leucine-rich repeat	638..662	CDD:275380	10/24 (42%)
		leucine-rich repeat	663..684	CDD:275380	8/20 (40%)
		leucine-rich repeat	685..708	CDD:275380	7/24 (29%)
		leucine-rich repeat	709..728	CDD:275380	4/34 (12%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
LRRC15	NP_001128529.2	LRR_8	60..119	CDD:290566	16/77 (21%)
		LRR_RI	63..309	CDD:238064	81/289 (28%)
		LRR_8	88..167	CDD:290566	28/102 (27%)
		leucine-rich repeat	88..108	CDD:275380	6/19 (32%)
		leucine-rich repeat	109..156	CDD:275380	16/70 (23%)
		leucine-rich repeat	157..180	CDD:275380	8/22 (36%)
		LRR_8	180..239	CDD:290566	26/58 (45%)
		leucine-rich repeat	181..204	CDD:275380	7/22 (32%)
		leucine-rich repeat	205..228	CDD:275380	11/22 (50%)
		LRR_8	228..287	CDD:290566	18/58 (31%)
		leucine-rich repeat	229..252	CDD:275380	9/22 (41%)
		leucine-rich repeat	253..276	CDD:275380	4/22 (18%)
		leucine-rich repeat	277..300	CDD:275380	5/22 (23%)
		LRR_8	299..359	CDD:290566	25/63 (40%)
		LRR_4	299..340	CDD:289563	19/44 (43%)
		leucine-rich repeat	301..324	CDD:275380	11/25 (44%)
		LRR_4	324..364	CDD:289563	13/39 (33%)
		leucine-rich repeat	325..348	CDD:275380	8/22 (36%)
		leucine-rich repeat	349..370	CDD:275380	6/20 (30%)
		LRR_8	372..430	CDD:290566	11/57 (19%)
		leucine-rich repeat	373..393	CDD:275380	3/19 (16%)
		leucine-rich repeat	397..418	CDD:275380	4/20 (20%)
		TPKR_C2	429..>468	CDD:301599	7/16 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8435
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910