Protein Alignment Toll-6 and LOC1270495

DIOPT Version :10

• Sequence 1: NP_524081.1
• Gene: Toll-6 / 39663
• FlyBaseID: FBgn0036494
• Length: 1514
• Species: Drosophila melanogaster
• Sequence 2: XP_309197.2
• Gene: LOC1270495 / 1270495
• VectorBaseID: AGAMI1_013423
• Length: 1152
• Species: Anopheles gambiae
• Alignment Length: 1464
• Identity: 337/1464 - (23%)
• Similarity: 525/1464 - (35%)
• Gaps: 475/1464 - (32%)

  Fly    79 DDCHFMPAAGLDQPEIALTCNLRTVNSEFDTTNFSVIPAEHTIALHILCNDEIMAKSRLEAQSFA 143
            |||.|.....:.|           :.|...||...|:..::.      .|.|..|.  |....||
Mosquito   111 DDCPFPHHQSILQ-----------LVSFLGTTQVKVLWLKNN------ANHEQSAS--LVRHHFA 156

  Fly   144 HLVRLQQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLS 208
            .|.:|.:|:|...||..:|..:.:.|..|..|.:| .||      |.:.|..|....:|..|:||
Mosquito   157 GLDQLDRLAISNAKLSDIGPDLFEHLPNLTWLDMR-DNI------FRLPATIFDALPKLRVLELS 214

  Fly   209 SNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSST 273
            .|::..|...:...|..|..|.:..|:|:.::...|.        |..|
Mosquito   215 FNSLEELDPRLLRHLPNLRLLTLWHNKLRTLSRAAFA--------GVPE---------------- 255

  Fly   274 SCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKI- 337
                 ||.||:|.|....:|.:.|..|..|..|::..|....:.|......:.|:.:.|:|.::
Mosquito   256 -----LERLDLSSNQLESVPGDLFADLPHLTELAMGVNNFRTLPDGLFRANRELRKVKLASQRVE 315

  Fly   338 -VALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALD-LSMNQITSTWIDKNTFVGLI 400
             ..||.:|                            |..|.||| :|:.::....:......|..
Mosquito   316 LETLPHDL----------------------------LQMLPALDQVSLERVGLVSLPGTLLFGSA 352

  Fly   401 RLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDA 465
            .|..|||::|:|.:|..::..|...||:|.|:||||..:.|........||||.||||::..|.|
Mosquito   353 NLTQLNLANNRLHQLPEDLLRDQKALQVLQLQHNQLTGLPAGLLRNTVELHTLRLSHNQIGELSA 417

  Fly   466 YALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENM 530
            .||..|..|..|.||:|.|..:...||:..:||..|:|..|||
Mosquito   418 VALQALTKLQELYLDHNQLYTIELHAFKQTTALHTLHLQVNQL---------------------- 460

  Fly   531 ITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQA 595
                   ||:.|..|..........|.:|.|                   :..|..|.:.:.
Mosquito   461 -------AFETLNTLPATAPDTGDQEQLTDH-------------------IPAPDEFSLLAQ--- 496

  Fly   596 VRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPST--LQWLDLHKNRLSSLSNRFGLD 658
               ||..       |.::..|..|::|.|.|.|.....:.:|  ||.|:|.:|.::||
Mosquito   497 ---DGTP-------FQHLHQLRELDLSSNWLTSVPRDLLLNTHELQRLNLTRNNITSL------- 544

  Fly   659 SELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLD 723
                      ::..||.:.|:               ||               |||..|.|..:|
Mosquito   545 ----------TYANLQFLAPA---------------IT---------------VDLRHNSIFEID 569

  Fly   724 IKSLRILPVWEHRALPE------FYIGGNPFTCDC----NIDWLQKINHITSRQYPRIMDLETIY 778
            :..:..|.:.|.|...|      ..:..||..|:|    ...::|  |.:.:..|.|.
Mosquito   570 LADMERLVLLEPRNFDEQTGRARVLLNDNPLHCNCIAYAFAQYIQ--NRLATAVYDRF------- 625

  Fly   779 CKLLNNRERAYIP------LIEAEP-KHFLCTYKTHCFAVCHCCEFDACDCEMTCPTNCTCFHDQ 836
             :|:.|....:.|      ||:..| :..||...|...|:.|            ||..|.|:...
Mosquito   626 -ELVANELTCHGPEHLEGALIKDVPTRELLCDLDTPSTAIRH------------CPAPCRCYIRP 677

  Fly   837 TWSTNIVECSGAAYSEMPRRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNT 901
            ..:..|::|||.|.:|:| .:|..|:    .|..|:|
Mosquito   678 EDTGVIIDCSGQALTEVP-ELPRPTT----FGYRFIE---------------------------- 709

  Fly   902 TFSGLKRLLILHLEDNHIISL------EGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVL 960
                      ||||:|:|.:|      .|:.  ....:||||..:|.||::|  :.|:.|.|.:|
Mosquito   710 ----------LHLENNNISALPDSTTASGSS--GWAEVRELYASNNSIAALA--ADQLPRSLRLL 760

  Fly   961 RLDGNRLMHFE---VWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEKIIDASRVSCIY 1022
            .|..|||...:   ...|:|:..|..:.||.|.|:|:| ...:...:...:..:|.|..|:.|
Mosquito   761 DLSRNRLTTLDGPLAESLTASTTLTTVRLAHNDWTCQC-ETTQLLTFAHANQRRIEDFGRLRC-- 822

  Fly  1023 NNATSVLREKNG---TKCTLRDGVAHYMHTNEIEGLLPLLLVATC-------AFVAFFGLIFGLF 1077
                     .:|   .:.||.|......|          ::|.||       ..||...|::  :
Mosquito   823 ---------SDGRPLEQMTLSDLCVDRTH----------IIVLTCVIVSVVACLVAALSLVY--Y 866

  Fly  1078 CYRHELKIWAHSTN-CLMNFCYKSPRFVDQLDKERPNDAYFAYSLQDEHFVNQILAQTLEND-IG 1140
            .|:.|||:|..... ||....      .::||:::..||:.:||.:||.|:.:.|..|||.| :.
Mosquito   867 TYKLELKVWLFKHGLCLWLVA------EEELDRDKLYDAFVSYSHKDEAFITEHLVPTLERDPMN 925

  Fly  1141 YRLCLHYRDVNINAYITDALIEAAESAKQFVLVLSKNFLYNEWSRFEYKSA-LHELVKRRKRVVF 1204
            ::||.|.||......|:..:..:.|.:::.::|||.:||.:.|.:.|:::| |..:.:||.|::.
Mosquito   926 FKLCWHVRDWTPGEMISSQISSSVEQSRRTIIVLSSSFLESLWGQLEFRTAHLQSMAERRNRLII 990

  Fly  1205 ILYGDLPQ-RDIDMDMRHYLRTSTCIEWDDKKFWQKLRLALPLPNGRGNNNKRVVSGCLSGRTPS 1268
            |:|||:.. .|::.::|.||.|:|.:.|.|..||.|||.|:|
Mosquito   991 IIYGDIGNIYDLEPELRAYLHTNTYVRWGDPWFWDKLRFAMP----------------------- 1032

  Fly  1269 VNMYATSHEYQAGNGGVIPPPSARYADCGSNNYATINECAAAGGGRGYKPIPTSASAAAAACKFN 1333
                   |           ||..|.|. |:.:....:..:.|||
Mosquito  1033 -------H-----------PPKVRGAS-GTASTVVKSGVSTAGG--------------------- 1057

  Fly  1334 TMNQLSKKQQRDLSVAGMAKTLEHQHHHNHQANRRSQHEYAVPSYLPSAAPAYDSVDYAKQQIRN 1398
                |..||                                    |..|||..|.::..|.|: .
Mosquito  1058 ----LFMKQ------------------------------------LQGAAPVDDRLELIKPQV-T 1081

  Fly  1399 NANCECVNLGTAKRAAGKNPASGLPSSFSSNFVPPGGASYNCKKSCSCIGDDELLCSCGGG-GGI 1462
            .|....:.....:..:...||.| |...|.|                           ||| ||.
Mosquito  1082 PATPPALTTPPTEPISSATPAPG-PFVISGN---------------------------GGGVGGA 1118

  Fly  1463 GVNLLESGTQSSVTMSSSSN-------NSRQPEL 1489
            |..||.....::...|...|       |::|.::
Mosquito  1119 GAQLLHQQLSNAYRASGHINGAFVINSNAKQSDV 1152

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_524081.1	PPP1R42	<135..>242	CDD:455733	30/106 (28%)
		leucine-rich repeat	148..171	CDD:275380	7/22 (32%)
		leucine-rich repeat	172..201	CDD:275380	8/28 (29%)
		LRR_8	200..>246	CDD:404697	12/45 (27%)
		leucine-rich repeat	202..278	CDD:275380	14/75 (19%)
		leucine-rich repeat	229..249	CDD:275380	4/19 (21%)
		leucine-rich repeat	279..302	CDD:275380	9/22 (41%)
		LRR	299..654	CDD:443914	89/359 (25%)
		leucine-rich repeat	303..326	CDD:275380	4/22 (18%)
		leucine-rich repeat	327..350	CDD:275380	6/24 (25%)
		leucine-rich repeat	352..375	CDD:275380	1/22 (5%)
		leucine-rich repeat	376..401	CDD:275380	6/25 (24%)
		leucine-rich repeat	402..425	CDD:275380	8/22 (36%)
		leucine-rich repeat	426..449	CDD:275380	9/22 (41%)
		leucine-rich repeat	450..473	CDD:275380	13/22 (59%)
		leucine-rich repeat	474..497	CDD:275380	8/22 (36%)
		leucine-rich repeat	498..518	CDD:275380	6/19 (32%)
		leucine-rich repeat	521..544	CDD:275380	3/22 (14%)
		leucine-rich repeat	545..566	CDD:275380	4/20 (20%)
		leucine-rich repeat	569..592	CDD:275380	2/22 (9%)
		leucine-rich repeat	593..615	CDD:275380	3/21 (14%)
		leucine-rich repeat	616..637	CDD:275380	6/20 (30%)
		leucine-rich repeat	638..662	CDD:275380	7/23 (30%)
		LRR_8	662..719	CDD:404697	9/56 (16%)
		leucine-rich repeat	663..684	CDD:275380	3/20 (15%)
		leucine-rich repeat	685..708	CDD:275380	2/22 (9%)
		leucine-rich repeat	709..728	CDD:275380	6/18 (33%)
		LRR	<863..>990	CDD:443914	32/135 (24%)
		leucine-rich repeat	885..908	CDD:275380	0/22 (0%)
		leucine-rich repeat	909..932	CDD:275380	8/28 (29%)
		leucine-rich repeat	933..956	CDD:275380	9/22 (41%)
		TIR	1114..1247	CDD:214587	50/135 (37%)
LOC1270495	XP_309197.2	None