DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and Rtn4r

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_446065.1 Gene:Rtn4r / 113912 RGDID:620810 Length:473 Species:Rattus norvegicus


Alignment Length:297 Identity:83/297 - (27%)
Similarity:135/297 - (45%) Gaps:45/297 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   328 QILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWID 392
            |.:.|..|:|..:|...| :..:.:..::|.:|:::.::...|:.|..|:.||||.|..... :|
  Rat    60 QRIFLHGNRISYVPAASF-QSCRNLTILWLHSNALAGIDAAAFTGLTLLEQLDLSDNAQLRV-VD 122

  Fly   393 KNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSH 457
            ..||.||..|..|:|....|.:|.|.:|..|..||.|.|:.|.|:.:..:||..:.||..|.|..
  Rat   123 PTTFRGLGHLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNNLQALPDNTFRDLGNLTHLFLHG 187

  Fly   458 NKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVP----LALRNM 518
            |::..:..:|..||:.|..|.|..|.:..|||.|||:...|..|.|..|.|..:|    :.||::
  Rat   188 NRIPSVPEHAFRGLHSLDRLLLHQNHVARVHPHAFRDLGRLMTLYLFANNLSMLPAEVLVPLRSL 252

  Fly   519 RHLRTVDLGEN-------------MITVMEDSAFKGLGNLYGLRLIGNYLEN----------ITM 560
            ::||   |.:|             .:.....|: .|:.:....||.|..|:.          :..
  Rat   253 QYLR---LNDNPWVCDCRARPLWAWLQKFRGSS-SGVPSNLPQRLAGRDLKRLATSDLEGCAVAS 313

  Fly   561 HTFR-----DLPNLQILNL-------ARNRIAVVEPG 585
            ..||     .|.:.::|.|       |.::.:|:|||
  Rat   314 GPFRPFQTNQLTDEELLGLPKCCQPDAADKASVLEPG 350

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380
LRR_8 171..236 CDD:290566
leucine-rich repeat 172..201 CDD:275380
leucine-rich repeat 202..278 CDD:275380
leucine-rich repeat 229..249 CDD:275380
LRR_RI 278..468 CDD:238064 42/139 (30%)
leucine-rich repeat 279..302 CDD:275380
LRR_8 301..386 CDD:290566 16/57 (28%)
leucine-rich repeat 303..326 CDD:275380
leucine-rich repeat 327..350 CDD:275380 6/21 (29%)
LRR 350..729 CDD:227223 77/275 (28%)
leucine-rich repeat 352..375 CDD:275380 4/22 (18%)
leucine-rich repeat 376..401 CDD:275380 11/24 (46%)
LRR_RI <401..626 CDD:238064 62/224 (28%)
leucine-rich repeat 402..425 CDD:275380 8/22 (36%)
leucine-rich repeat 426..449 CDD:275380 8/22 (36%)
leucine-rich repeat 450..473 CDD:275380 7/22 (32%)
leucine-rich repeat 474..497 CDD:275380 10/22 (45%)
leucine-rich repeat 498..518 CDD:275380 8/23 (35%)
leucine-rich repeat 521..544 CDD:275380 6/35 (17%)
leucine-rich repeat 545..566 CDD:275380 6/35 (17%)
leucine-rich repeat 569..592 CDD:275380 7/24 (29%)
leucine-rich repeat 593..615 CDD:275380
leucine-rich repeat 616..637 CDD:275380
leucine-rich repeat 638..662 CDD:275380
leucine-rich repeat 663..684 CDD:275380
leucine-rich repeat 685..708 CDD:275380
leucine-rich repeat 709..728 CDD:275380
LRR_8 883..943 CDD:290566
leucine-rich repeat 885..908 CDD:275380
leucine-rich repeat 909..932 CDD:275380
LRR_8 932..990 CDD:290566
leucine-rich repeat 933..956 CDD:275380
TIR 1114..1247 CDD:214587
Rtn4rNP_446065.1 LRR 1. /evidence=ECO:0000255 56..79 6/19 (32%)
LRR_8 60..115 CDD:290566 15/55 (27%)
leucine-rich repeat 60..82 CDD:275380 6/22 (27%)
LRR 2. /evidence=ECO:0000255 80..103 3/22 (14%)
LRR_RI 81..>261 CDD:238064 60/183 (33%)
leucine-rich repeat 83..106 CDD:275380 4/22 (18%)
LRR 3. /evidence=ECO:0000255 105..128 9/23 (39%)
leucine-rich repeat 107..131 CDD:275380 11/24 (46%)
LRR 4. /evidence=ECO:0000255 129..152 8/22 (36%)
LRR_8 131..190 CDD:290566 21/58 (36%)
leucine-rich repeat 132..155 CDD:275380 8/22 (36%)
LRR 5. /evidence=ECO:0000255 153..176 9/22 (41%)
LRR_4 156..195 CDD:289563 13/38 (34%)
leucine-rich repeat 156..179 CDD:275380 8/22 (36%)
LRR 6. /evidence=ECO:0000255 178..200 6/21 (29%)
LRR_8 179..238 CDD:290566 22/58 (38%)
leucine-rich repeat 180..203 CDD:275380 7/22 (32%)
LRR 7. /evidence=ECO:0000255 202..224 9/21 (43%)
leucine-rich repeat 204..227 CDD:275380 10/22 (45%)
LRR 8. /evidence=ECO:0000255 225..248 6/22 (27%)
leucine-rich repeat 228..251 CDD:275380 7/22 (32%)
LRR 9. /evidence=ECO:0000255 250..273 5/25 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 346..446 4/5 (80%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR45836
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

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