DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Toll-6 and Lgr4

DIOPT Version :10

Sequence 1:NP_524081.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_766259.2 Gene:Lgr4 / 107515 MGIID:1891468 Length:951 Species:Mus musculus


Alignment Length:920 Identity:201/920 - (21%)
Similarity:324/920 - (35%) Gaps:288/920 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   264 SAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQ 328
            |.|..::.....|...:.||:|.|:...||.:.|.....|..|.:..|.:|.|..|||||||.|:
Mouse    44 SGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELK 108

  Fly   329 ILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDK 393
            :|.|.:|::..:|:|                         ....|..||:|.|..|.|||  :.:
Mouse   109 VLTLQNNQLKTVPSE-------------------------AIRGLSALQSLRLDANHITS--VPE 146

  Fly   394 NTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHN 458
            ::|.||::|..|.|..|.||::.....|:|.|||.|.|..|.:.:|....|..:::|..|.|.:|
Mouse   147 DSFEGLVQLRHLWLDDNILTEVPVRPLSNLPTLQALTLALNNISSIPDFAFTNLSSLVVLHLHNN 211

  Fly   459 KLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVP-LALRNMRHLR 522
            |:|.|..:..:||..|..|.|:.|.| ...|.|.:...:|::|..:.|.:..:| .|......||
Mouse   212 KIKSLSQHCFDGLDNLETLDLNYNNL-DEFPQAIKALPSLKELGFHSNSISVIPDGAFAGNPLLR 275

  Fly   523 TVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAF 587
            |:.|.:|.::.:.:|||..|.:|:.|.:.|..|       .:..|||                  
Mouse   276 TIHLYDNPLSFVGNSAFHNLSDLHSLVIRGASL-------VQWFPNL------------------ 315

  Fly   588 EMTSSIQAVRLDGNELNDI-NGLFSNMPSLLWLNISDNRLESFDYGHVPS-----TLQWLDLHKN 646
            ..|..::::.|.|.:::.| :.|..|...|..|::|.|     |...:||     .|:.:.|.:|
Mouse   316 AGTVHLESLTLTGTKISSIPDDLCQNQKMLRTLDLSYN-----DIRDLPSFNGCRALEEISLQRN 375

  Fly   647 RLSSLSNRFGLDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTR 711
            ::|.:.              :.:|..|         .|:.:|.|:.|||..:....|.....:|.
Mouse   376 QISLIK--------------ETTFQGL---------TSLRILDLSRNLIREIHSGAFAKLGTITN 417

  Fly   712 VDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLET 776
            :|:..|::|:...:.|        ..|.:..:.||          .|..:.:.:|.:..:..|..
Mouse   418 LDVSFNELTSFPTEGL--------NGLNQLKLVGN----------FQLKDALAARDFANLRSLSV 464

  Fly   777 IYCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACD--CEMTCPTNCTCFHDQT-- 837
            .|         ||                       .||.|..||  ..:....|....|..|  
Mouse   465 PY---------AY-----------------------QCCAFWGCDSYANLNTEDNSPQDHSVTKE 497

  Fly   838 -WSTNIVECSGAAYSEMPRRV------------PMDTSELYIDGNNFVEL-AGHSFLGRKNLAVL 888
             .:|:....:..|.||...::            |.:    |:.|:..:.| ....||        
Mouse   498 KGATDAANATSTAESEEHSQIIIHCTPSTGAFKPCE----YLLGSWMIRLTVWFIFL-------- 550

  Fly   889 YANNSNVAHIYN-----TTFSGLKRL----LILHLEDNHIISLEGNEFHNLENLRELYLQSNKIA 944
                  ||.::|     |.|:....|    |.:.|     ||:                 ||.:.
Mouse   551 ------VALLFNLLVILTVFASCSSLPASKLFIGL-----ISV-----------------SNLLM 587

  Fly   945 SIANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQW----SCE-CGYLARFRNY 1004
            .|..|....|.     .:...|...|.:|                 |    .|: .|.||.|   
Mouse   588 GIYTGILTFLD-----AVSWGRFAEFGIW-----------------WETGSGCKVAGSLAVF--- 627

  Fly  1005 LGQSSEKIIDASRVSCIYNNATSVLREKNGTKCTLRD---------------GVAHYMH------ 1048
               |||..:....::.:..:..:....|||....||.               |.....|      
Mouse   628 ---SSESAVFLLTLAAVERSVFAKDVMKNGKSSHLRQFQVAALVALLGAAIAGCFPLFHGGQYSA 689

  Fly  1049 --------TNEIEGL---LPLLLVATCAFVAFFGLIFGLFC---------------YRHELKIWA 1087
                    |.|...|   :.|:|:.:.||:....:...|:|               .:|  ..|.
Mouse   690 SPLCLPFPTGETPSLGFTVTLVLLNSLAFLLMAIIYTKLYCNLEKEDPSENSQSSMIKH--VAWL 752

  Fly  1088 HSTNCLMNFC 1097
            ..|||:. ||
Mouse   753 IFTNCIF-FC 761

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_524081.1 PPP1R42 <135..>242 CDD:455733
leucine-rich repeat 148..171 CDD:275380
leucine-rich repeat 172..201 CDD:275380
LRR_8 200..>246 CDD:404697
leucine-rich repeat 202..278 CDD:275380 3/13 (23%)
leucine-rich repeat 229..249 CDD:275380
leucine-rich repeat 279..302 CDD:275380 7/22 (32%)
LRR 299..654 CDD:443914 100/361 (28%)
leucine-rich repeat 303..326 CDD:275380 11/22 (50%)
leucine-rich repeat 327..350 CDD:275380 6/22 (27%)
leucine-rich repeat 352..375 CDD:275380 1/22 (5%)
leucine-rich repeat 376..401 CDD:275380 11/24 (46%)
leucine-rich repeat 402..425 CDD:275380 8/22 (36%)
leucine-rich repeat 426..449 CDD:275380 7/22 (32%)
leucine-rich repeat 450..473 CDD:275380 9/22 (41%)
leucine-rich repeat 474..497 CDD:275380 7/22 (32%)
leucine-rich repeat 498..518 CDD:275380 5/20 (25%)
leucine-rich repeat 521..544 CDD:275380 9/22 (41%)
leucine-rich repeat 545..566 CDD:275380 4/20 (20%)
leucine-rich repeat 569..592 CDD:275380 2/22 (9%)
leucine-rich repeat 593..615 CDD:275380 5/22 (23%)
leucine-rich repeat 616..637 CDD:275380 7/25 (28%)
leucine-rich repeat 638..662 CDD:275380 4/23 (17%)
LRR_8 662..719 CDD:404697 12/56 (21%)
leucine-rich repeat 663..684 CDD:275380 2/20 (10%)
leucine-rich repeat 685..708 CDD:275380 6/22 (27%)
leucine-rich repeat 709..728 CDD:275380 4/18 (22%)
LRR <863..>990 CDD:443914 23/136 (17%)
leucine-rich repeat 885..908 CDD:275380 5/27 (19%)
leucine-rich repeat 909..932 CDD:275380 5/26 (19%)
leucine-rich repeat 933..956 CDD:275380 5/22 (23%)
TIR 1114..1247 CDD:214587
Lgr4NP_766259.2 LRRNT 29..61 CDD:214470 3/16 (19%)
LRR 1 58..79 7/20 (35%)
leucine-rich repeat 59..82 CDD:275380 7/22 (32%)
LRR <75..384 CDD:443914 101/380 (27%)
LRR 2 82..103 8/20 (40%)
leucine-rich repeat 83..106 CDD:275380 11/22 (50%)
LRR 3 106..127 6/45 (13%)
leucine-rich repeat 107..130 CDD:275380 7/47 (15%)
LRR 4 130..151 9/22 (41%)
leucine-rich repeat 131..154 CDD:275380 11/24 (46%)
LRR 5 154..177 7/22 (32%)
leucine-rich repeat 155..178 CDD:275380 8/22 (36%)
LRR 6 178..199 8/20 (40%)
leucine-rich repeat 179..202 CDD:275380 7/22 (32%)
LRR 7 202..223 7/20 (35%)
leucine-rich repeat 203..226 CDD:275380 9/22 (41%)
LRR 8 226..247 7/21 (33%)
leucine-rich repeat 227..249 CDD:275380 7/22 (32%)
LRR 9 249..270 5/20 (25%)
leucine-rich repeat 250..273 CDD:275380 5/22 (23%)
LRR 10 273..294 8/20 (40%)
leucine-rich repeat 274..295 CDD:275380 8/20 (40%)
LRR 11 320..341 4/20 (20%)
leucine-rich repeat 321..344 CDD:275380 5/22 (23%)
LRR 12 344..365 7/25 (28%)
leucine-rich repeat 345..366 CDD:275380 7/25 (28%)
LRR_8 365..425 CDD:404697 16/82 (20%)
LRR 13 366..387 5/34 (15%)
leucine-rich repeat 367..390 CDD:275380 6/45 (13%)
LRR 14 390..411 7/20 (35%)
leucine-rich repeat 391..414 CDD:275380 6/22 (27%)
LRR 15 414..435 5/28 (18%)
leucine-rich repeat 415..438 CDD:275380 6/30 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 487..512 5/24 (21%)
7tmA_LGR4 539..812 CDD:320483 53/290 (18%)
TM helix 1 540..566 CDD:320483 8/39 (21%)
TM helix 2 573..598 CDD:320483 8/46 (17%)
TM helix 3 618..648 CDD:320483 8/35 (23%)
TM helix 4 660..682 CDD:320483 2/21 (10%)
TM helix 5 702..731 CDD:320483 6/28 (21%)
TM helix 6 740..770 CDD:320483 7/25 (28%)
TM helix 7 780..805 CDD:320483
Blue background indicates that the domain is not in the aligned region.

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