DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-6 and lrtm2b

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	XP_005163087.1	Gene:	lrtm2b / 101887010	ZFINID:	ZDB-GENE-131121-544	Length:	408	Species:	Danio rerio

Alignment Length:	251	Identity:	80/251 - (31%)
Similarity:	113/251 - (45%)	Gaps:	32/251 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 SSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLK-NLQILN 331
            |.|....||.::...|.||             |.:|..|           |..|..|. :...||
Zfish    19 SKSCPLLCSCNINQTDCSH-------------LYQLASL-----------DSILEQLPFDTTNLN 59

  Fly   332 LSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTF 396
            ||.|....:....|:..:.::|..| ..|.:|.:||..||||..|..||||.|.::..:  .::|
Zfish    60 LSKNNFTTVEPGSFSNLSALLQLDY-SRNLLSAINPGCFSNLSGLLHLDLSRNLLSRVF--PSSF 121

  Fly   397 VGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLK 461
            ..|..|..|:||.|.|.:|...:||||.:|..|.||.|:|:.:....|..:..|..|.||.|.|.
Zfish   122 SHLNSLEFLDLSVNLLVRLPVNLFSDLSSLNELVLRDNRLKELNPAQFKGLTELRRLDLSLNSLS 186

  Fly   462 YLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGN----QLKTVPL 513
            ::..:.|:||..|..|||..|.|..:...:..:.:|||.|.|.||    ..|.:||
Zfish   187 HVPTHLLDGLQNLLWLSLVGNKLKTLDRSSLESANALQQLLLEGNPWNCNCKLIPL 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	4/9 (44%)
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	57/190 (30%)
		leucine-rich repeat	279..302	CDD:275380	4/22 (18%)
		LRR_8	301..386	CDD:290566	27/85 (32%)
		leucine-rich repeat	303..326	CDD:275380	5/23 (22%)
		leucine-rich repeat	327..350	CDD:275380	6/22 (27%)
		LRR	350..729	CDD:227223	61/168 (36%)
		leucine-rich repeat	352..375	CDD:275380	10/22 (45%)
		leucine-rich repeat	376..401	CDD:275380	8/24 (33%)
		LRR_RI	<401..626	CDD:238064	43/117 (37%)
		leucine-rich repeat	402..425	CDD:275380	11/22 (50%)
		leucine-rich repeat	426..449	CDD:275380	7/22 (32%)
		leucine-rich repeat	450..473	CDD:275380	9/22 (41%)
		leucine-rich repeat	474..497	CDD:275380	6/22 (27%)
		leucine-rich repeat	498..518	CDD:275380	9/20 (45%)
		leucine-rich repeat	521..544	CDD:275380
		leucine-rich repeat	545..566	CDD:275380
		leucine-rich repeat	569..592	CDD:275380
		leucine-rich repeat	593..615	CDD:275380
		leucine-rich repeat	616..637	CDD:275380
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
lrtm2b	XP_005163087.1	leucine-rich repeat	34..54	CDD:275380	9/43 (21%)
		leucine-rich repeat	55..78	CDD:275380	6/22 (27%)
		LRR_8	56..113	CDD:290566	22/57 (39%)
		leucine-rich repeat	79..102	CDD:275380	10/23 (43%)
		Allexi_40kDa	97..>215	CDD:253247	45/119 (38%)
		LRR_8	101..161	CDD:290566	24/61 (39%)
		leucine-rich repeat	103..126	CDD:275380	8/24 (33%)
		leucine-rich repeat	127..150	CDD:275380	11/22 (50%)
		LRR_8	149..209	CDD:290566	21/59 (36%)
		leucine-rich repeat	151..174	CDD:275380	7/22 (32%)
		leucine-rich repeat	175..198	CDD:275380	9/22 (41%)
		leucine-rich repeat	199..222	CDD:275380	6/22 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45836
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100