Protein Alignment Toll-6 and nyx

DIOPT Version :10

• Sequence 1: NP_524081.1
• Gene: Toll-6 / 39663
• FlyBaseID: FBgn0036494
• Length: 1514
• Species: Drosophila melanogaster
• Sequence 2: XP_031752664.1
• Gene: nyx / 100495354
• XenbaseID: XB-GENE-949924
• Length: 468
• Species: Xenopus tropicalis
• Alignment Length: 585
• Identity: 127/585 - (21%)
• Similarity: 190/585 - (32%)
• Gaps: 246/585 - (42%)

  Fly   212 IW----SLPDNIFCTLSELSALNMSENRLQDV--NELGFRDRSKE-PTNGSTESTSTTESAKKSS 269
            ||    |.|.|..||          :.|...|  :.:|..:..|| |...|
 Frog    22 IWACYRSCPSNCVCT----------QERSCSVLCDRIGLPEIPKEFPCEAS-------------- 62

  Fly   270 SSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSS 334
                       ::::..|:...|....||||..|:.||:::|.||.|...|..||.||..|.::.
 Frog    63 -----------FINLDKNNIKFLYERAFGTLPLLKGLSLSHNNISFITPGAFKGLPNLTELKMAH 116

  Fly   335 NKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGL 399
            |:.:.                ||...:.|||.
 Frog   117 NEYIR----------------YLHTRTFSVLK--------------------------------- 132

  Fly   400 IRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLD 464
             :||.|:|:...|..:...||.:|.:|..|....|....|.. ....|.||..:.|..|:::.:.
 Frog   133 -KLVKLDLADCNLFNIPDRIFVELPSLHELIFFQNNFRRIPG-AIRGMENLTHIYLESNRIEAVA 195

  Fly   465 AYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGEN 529
            ..:|..|..|..|:|.:|.:..:|..:|::|..|:.|.||.|.|..:|
 Frog   196 YNSLQDLINLKYLNLQDNKINVIHDRSFQDCQKLEYLYLNDNLLNELP----------------- 243

  Fly   530 MITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQ 594
                  :::||||..|..|.|.||::.|::...|:||..|::|.|.||||:.:|.||||
 Frog   244 ------ENSFKGLKCLKMLNLGGNFIRNVSSAWFQDLVELEVLYLDRNRISYIEEGAFE------ 296

  Fly   595 AVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPSTLQWLDLHKNRLSSLSNRFGLDS 659
                             |:.||:.|:::.|.|
 Frog   297 -----------------NLTSLVTLHLNSNNL--------------------------------- 311

  Fly   660 ELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLITTVDPDTFMHKTNLTRVDLYANQITTLDI 724
                                                                        |||..
 Frog   312 ------------------------------------------------------------TTLPF 316

  Fly   725 KSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQ--KINHITSRQYP-------RIMDLETIYCK 780
            :..|  ||:   .|...::..||:.|||.|.|||  ..|:...|..|       ..|||.:|..|
 Frog   317 EVFR--PVY---FLGRLFLFRNPWECDCRIKWLQDWMDNYKLVRDVPCSAPALVAGMDLSSILLK 376

  Fly   781  780
             Frog   377  376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_524081.1	PPP1R42	<135..>242	CDD:455733	9/35 (26%)
		leucine-rich repeat	148..171	CDD:275380
		leucine-rich repeat	172..201	CDD:275380
		LRR_8	200..>246	CDD:404697	10/39 (26%)
		leucine-rich repeat	202..278	CDD:275380	14/72 (19%)
		leucine-rich repeat	229..249	CDD:275380	3/21 (14%)
		leucine-rich repeat	279..302	CDD:275380	6/22 (27%)
		LRR	299..654	CDD:443914	85/354 (24%)
		leucine-rich repeat	303..326	CDD:275380	10/22 (45%)
		leucine-rich repeat	327..350	CDD:275380	3/22 (14%)
		leucine-rich repeat	352..375	CDD:275380	5/22 (23%)
		leucine-rich repeat	376..401	CDD:275380	0/24 (0%)
		leucine-rich repeat	402..425	CDD:275380	8/22 (36%)
		leucine-rich repeat	426..449	CDD:275380	5/22 (23%)
		leucine-rich repeat	450..473	CDD:275380	5/22 (23%)
		leucine-rich repeat	474..497	CDD:275380	7/22 (32%)
		leucine-rich repeat	498..518	CDD:275380	7/19 (37%)
		leucine-rich repeat	521..544	CDD:275380	4/22 (18%)
		leucine-rich repeat	545..566	CDD:275380	7/20 (35%)
		leucine-rich repeat	569..592	CDD:275380	12/22 (55%)
		leucine-rich repeat	593..615	CDD:275380	1/21 (5%)
		leucine-rich repeat	616..637	CDD:275380	4/20 (20%)
		leucine-rich repeat	638..662	CDD:275380	0/23 (0%)
		LRR_8	662..719	CDD:404697	0/56 (0%)
		leucine-rich repeat	663..684	CDD:275380	0/20 (0%)
		leucine-rich repeat	685..708	CDD:275380	0/22 (0%)
		leucine-rich repeat	709..728	CDD:275380	3/18 (17%)
		LRR	<863..>990	CDD:443914
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
nyx	XP_031752664.1	LRR	42..>319	CDD:443914	98/491 (20%)
		leucine-rich repeat	65..84	CDD:275380	6/18 (33%)
		leucine-rich repeat	85..108	CDD:275380	10/22 (45%)
		leucine-rich repeat	109..133	CDD:275380	8/73 (11%)
		leucine-rich repeat	134..157	CDD:275380	8/22 (36%)
		leucine-rich repeat	158..180	CDD:275380	5/22 (23%)
		leucine-rich repeat	181..204	CDD:275380	5/22 (23%)
		leucine-rich repeat	205..228	CDD:275380	7/22 (32%)
		leucine-rich repeat	229..252	CDD:275380	11/45 (24%)
		leucine-rich repeat	253..276	CDD:275380	9/22 (41%)
		leucine-rich repeat	277..298	CDD:275380	12/43 (28%)
		PCC	282..>401	CDD:188093	40/216 (19%)
		leucine-rich repeat	301..324	CDD:275380	10/120 (8%)