DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Toll-6 and lrrtm1

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	XP_002935525.1	Gene:	lrrtm1 / 100493874	XenbaseID:	XB-GENE-966481	Length:	521	Species:	Xenopus tropicalis

Alignment Length:	456	Identity:	112/456 - (24%)
Similarity:	199/456 - (43%)	Gaps:	103/456 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   209 SNNIWSLPDNIFCTLSELSALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSST 273
            |.|:..:|.|    ||.:..|::..|.|.::.:..|
Frog    54 SQNVTEIPHN----LSGVMGLSLRYNSLSELQDGQF----------------------------- 85

  Fly   274 SCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIV 338
            :..:.|.:|.:.||....:..|.|..|||::.|::::|.|:.:|:.....:.||:.::||:|.:.
Frog    86 TGLIQLTWLYLDHNHIHTVEGNAFHKLRRVKELTLSSNKITHLANTTFRPMPNLRSVDLSNNNLQ 150

  Fly   339 ALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLV 403
            :|..:||....| :..::::.|:|..:..::|.:...|:.|||..||:.|  :.:|:|.||.:|.
Frog   151 SLEADLFHGLRK-LTTLHMRYNAIKFVPVRIFQDCRSLKFLDLGYNQLKS--LARNSFAGLFKLT 212

  Fly   404 LLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYAL 468
            .|:|.||.|.|:....|..|.:|..|.:|.|:: .|..::...:..|..:.||.|:::|::.:..
Frog   213 ELHLEHNDLVKVNLAHFPRLLSLHSLFMRRNKV-TIVVNSLDFVWKLEKMDLSGNEIEYIEPHVF 276

  Fly   469 NGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITV 533
            ..|..|..|.||:|.|..|.|....:..:|..:.|.||..                |.|.|:..:
Frog   277 ESLPHLESLQLDSNRLTYVDPRILNSWKSLSSITLAGNNW----------------DCGRNVCAL 325

  Fly   534 ME-DSAFKGLGNLYGLRLIGNYL---------ENI--TMHTFR------DLPNLQILNLARN--- 577
            .. .|||||       |..||.|         |::  .::.||      |..:...::.|.|
Frog   326 ASWLSAFKG-------RCDGNMLCTTPEYAQGEDVLDAVYFFRLCDDPVDPTSANAISTALNNSD 383

  Fly   578 RIAVVEPGAF---------EMTSSIQAVRLDGNELND--------ING----LFSNMPSLLWLNI 621
            |||:..|.|.         |.|:::|...: .||.::        :.|    :||.:..:|.|.:
Frog   384 RIAIDSPTATSYNVQDTEGERTTNVQTATV-ANEHHENTVQIHKVVTGTMALIFSFLIVVLMLYV 447

  Fly   622 S 622
            |
Frog   448 S 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566	8/26 (31%)
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380	10/68 (15%)
		leucine-rich repeat	229..249	CDD:275380	4/19 (21%)
		LRR_RI	278..468	CDD:238064	55/189 (29%)
		leucine-rich repeat	279..302	CDD:275380	7/22 (32%)
		LRR_8	301..386	CDD:290566	23/84 (27%)
		leucine-rich repeat	303..326	CDD:275380	4/22 (18%)
		leucine-rich repeat	327..350	CDD:275380	7/22 (32%)
		LRR	350..729	CDD:227223	81/315 (26%)
		leucine-rich repeat	352..375	CDD:275380	3/22 (14%)
		leucine-rich repeat	376..401	CDD:275380	11/24 (46%)
		LRR_RI	<401..626	CDD:238064	66/264 (25%)
		leucine-rich repeat	402..425	CDD:275380	9/22 (41%)
		leucine-rich repeat	426..449	CDD:275380	5/22 (23%)
		leucine-rich repeat	450..473	CDD:275380	6/22 (27%)
		leucine-rich repeat	474..497	CDD:275380	8/22 (36%)
		leucine-rich repeat	498..518	CDD:275380	4/19 (21%)
		leucine-rich repeat	521..544	CDD:275380	8/23 (35%)
		leucine-rich repeat	545..566	CDD:275380	7/37 (19%)
		leucine-rich repeat	569..592	CDD:275380	9/34 (26%)
		leucine-rich repeat	593..615	CDD:275380	6/33 (18%)
		leucine-rich repeat	616..637	CDD:275380	3/7 (43%)
		leucine-rich repeat	638..662	CDD:275380
		leucine-rich repeat	663..684	CDD:275380
		leucine-rich repeat	685..708	CDD:275380
		leucine-rich repeat	709..728	CDD:275380
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
lrrtm1	XP_002935525.1	LRRNT	38..>61	CDD:214470	2/6 (33%)
		LRR	53..>316	CDD:227223	78/298 (26%)
		leucine-rich repeat	70..90	CDD:275380	4/48 (8%)
		leucine-rich repeat	91..114	CDD:275380	7/22 (32%)
		LRR_8	114..173	CDD:338972	15/59 (25%)
		leucine-rich repeat	115..138	CDD:275380	4/22 (18%)
		leucine-rich repeat	139..162	CDD:275380	7/22 (32%)
		leucine-rich repeat	163..186	CDD:275380	3/22 (14%)
		leucine-rich repeat	187..210	CDD:275380	11/24 (46%)
		leucine-rich repeat	211..234	CDD:275380	9/22 (41%)
		leucine-rich repeat	235..257	CDD:275380	5/22 (23%)
		leucine-rich repeat	258..281	CDD:275380	6/22 (27%)
		leucine-rich repeat	282..300	CDD:275380	8/17 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910