Protein Alignment Toll-6 and tlrs5

DIOPT Version :10

• Sequence 1: NP_524081.1
• Gene: Toll-6 / 39663
• FlyBaseID: FBgn0036494
• Length: 1514
• Species: Drosophila melanogaster
• Sequence 2: XP_002937550.2
• Gene: tlrs5 / 100489423
• XenbaseID: XB-GENE-22201327
• Length: 653
• Species: Xenopus tropicalis
• Alignment Length: 791
• Identity: 178/791 - (22%)
• Similarity: 305/791 - (38%)
• Gaps: 225/791 - (28%)

  Fly   289 FVVLPANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQ 353
            |.|...:||..|.       ||:......||:..      :.|..:|.:.::|:.:..:    .|
 Frog    11 FPVSLLSGFQPLS-------NNSNCKAFQDKSHF------VFNCLANGLYSIPSHIPPQ----TQ 58

  Fly   354 EVYLQNNSISVLNPQLFSNLDQLQALDLSMNQITSTW-IDKNTFVGLIRLVLLNLSHNKLTKLEP 417
            .:....|.|..::...|.:|..||.|.|.......|: :.|:.|.|...|:.|:|..|::..|.|
 Frog    59 SLLFSFNRIPSISQDSFPDLLHLQTLLLGSQVTPGTFSVGKSAFRGFPNLITLDLGGNRIINLHP 123

  Fly   418 EIFSDLYTLQILNLRHNQLEN--IAADTFAPMNNLHTLLLSHNKLKYL--DAYALNGLYVLSLLS 478
            |.|..|..|::|.|.||.|:.  :.:..|..:.:|..|.||.|.::.:  |...|. |..:|.|.
 Frog   124 EAFEGLSWLEVLLLDHNGLDESVLESGMFKDLTSLKKLDLSFNNIRRVRPDPTFLK-LSSISFLL 187

  Fly   479 LDNNALIGVHPDAFRNCSAL--QDL-NLNGNQLKTV-----PLALRNMRH---------LRTVDL 526
            |           .|...|.|  :|| ||.|.:|:.:     ||.|.:..|         |.|:|:
 Frog   188 L-----------KFNKVSMLCGEDLQNLQGRRLQLLDMSSNPLQLSSTPHCTNPFNNITLGTLDV 241

  Fly   527 G---------ENMITVMEDSAF--------KGLGNLYGLRLIGNYLENITMHTFRDL--PNLQIL 572
            .         ||.:..:..:..        .|||:.:|.    :.|::....||..|  .|:|||
 Frog   242 SSMGWNAEMVENFVRTISGTQVDYIKMRHTAGLGSGFGF----HNLKDPNKDTFSGLNSSNVQIL 302

  Fly   573 NLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDI-NGLFSNMPSLLWLNISDNRL-----ESFDY 631
            :|:...|:.:.|..|.....:.::.|..|::|.: :|.||.:..|:.||:|.|.|     .||.
 Frog   303 DLSNGFISHLVPQLFSAFPKLLSLDLSSNQINRMSSGAFSGLGELVSLNLSGNLLGELMGSSFQ- 366

  Fly   632 GHVPSTLQWLDLHKNRLSSLSNRFG-LDSELKLQTLDVSFNQLQRIGPSSIPNSIELLFLNDNLI 695
            |...::|:.|||..|.:.::  ::| |||...|.:|::..|.|.:|.|:.: ..:..:.|..|.|
 Frog   367 GLGATSLKTLDLSSNHIGAV--QYGALDSFTALTSLNLRDNALNKIPPTKL-QGVTFVLLKQNRI 428

  Fly   696 TTVDPDTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYIGGNPFTCDCNIDWLQKI 760
            :.: .:......:.|.:||.:|::|  |.:||     |:
 Frog   429 SDI-YNIISFCPHATILDLSSNRLT--DFRSL-----WQ-------------------------- 459

  Fly   761 NHITSRQYPRIMDLETI-YCKLLNNRERAYIPLIEAEPKHFLCTYKTHCFAVCHCCEFDACDCEM 824
                      |::|::: |..|.:|                 ..|:
 Frog   460 ----------ILELQSLKYLSLASN-----------------SLYR------------------- 478

  Fly   825 TCPTNCTCFHDQTWSTNIVECSGAAYSEMPRRVPMDTSELYID--------GNNFVELAGHSFLG 881
                 |:..|    ::||...||..|        :|.|:..:.        |:.|:.|..   |.
 Frog   479 -----CSLPH----TSNITRTSGLVY--------LDLSDNALGPVLKSGECGDIFMHLGS---LK 523

  Fly   882 RKNLAVLYANNSNVAHIYNTTFSGLKRLLILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASI 946
            ..|||     .:.:::|.:|.|..|..|..|.|..|....::.|.|..|..|:.|.|..:.:.::
 Frog   524 SLNLA-----RNQLSNIPDTMFRSLSSLQTLDLSGNGFKEIQSNLFTGLTALKTLNLGKSNLVTL 583

  Fly   947 ANGSFQMLRKLEVLRLDGNRLMHFEVWQLSANPYLVEISLADNQWSCECGYLARFRNYLGQSSEK 1011
            ::.....|..||.:.|.                   |::|.     |:|. |..|..:|..::..
 Frog   584 SSSVLDPLGSLESIDLS-------------------EVTLV-----CDCS-LWDFWKWLEDTNVT 623

  Fly  1012 I-IDASRVSCI 1021
            : :....|.||
 Frog   624 VNVGKQEVLCI 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_524081.1	PPP1R42	<135..>242	CDD:455733
		leucine-rich repeat	148..171	CDD:275380
		leucine-rich repeat	172..201	CDD:275380
		LRR_8	200..>246	CDD:404697
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		leucine-rich repeat	279..302	CDD:275380	5/12 (42%)
		LRR	299..654	CDD:443914	102/401 (25%)
		leucine-rich repeat	303..326	CDD:275380	4/22 (18%)
		leucine-rich repeat	327..350	CDD:275380	3/22 (14%)
		leucine-rich repeat	352..375	CDD:275380	5/22 (23%)
		leucine-rich repeat	376..401	CDD:275380	8/25 (32%)
		leucine-rich repeat	402..425	CDD:275380	9/22 (41%)
		leucine-rich repeat	426..449	CDD:275380	7/24 (29%)
		leucine-rich repeat	450..473	CDD:275380	8/24 (33%)
		leucine-rich repeat	474..497	CDD:275380	4/22 (18%)
		leucine-rich repeat	498..518	CDD:275380	10/27 (37%)
		leucine-rich repeat	521..544	CDD:275380	7/39 (18%)
		leucine-rich repeat	545..566	CDD:275380	4/20 (20%)
		leucine-rich repeat	569..592	CDD:275380	7/22 (32%)
		leucine-rich repeat	593..615	CDD:275380	6/22 (27%)
		leucine-rich repeat	616..637	CDD:275380	9/25 (36%)
		leucine-rich repeat	638..662	CDD:275380	9/24 (38%)
		LRR_8	662..719	CDD:404697	13/56 (23%)
		leucine-rich repeat	663..684	CDD:275380	6/20 (30%)
		leucine-rich repeat	685..708	CDD:275380	3/22 (14%)
		leucine-rich repeat	709..728	CDD:275380	7/18 (39%)
		LRR	<863..>990	CDD:443914	27/134 (20%)
		leucine-rich repeat	885..908	CDD:275380	6/22 (27%)
		leucine-rich repeat	909..932	CDD:275380	7/22 (32%)
		leucine-rich repeat	933..956	CDD:275380	4/22 (18%)
		TIR	1114..1247	CDD:214587
tlrs5	XP_002937550.2	RNA1	<100..269	CDD:444072	47/180 (26%)
		LRR_8	106..168	CDD:404697	21/61 (34%)
		leucine-rich repeat	108..131	CDD:275380	9/22 (41%)
		leucine-rich repeat	132..157	CDD:275380	7/24 (29%)
		leucine-rich repeat	158..182	CDD:275380	8/24 (33%)
		leucine-rich repeat	183..208	CDD:275380	11/35 (31%)
		leucine-rich repeat	209..232	CDD:275380	5/22 (23%)
		LRR	291..632	CDD:443914	99/474 (21%)
		leucine-rich repeat	299..322	CDD:275380	7/22 (32%)
		leucine-rich repeat	323..346	CDD:275380	6/22 (27%)
		leucine-rich repeat	347..372	CDD:275380	9/25 (36%)
		leucine-rich repeat	373..396	CDD:275380	9/24 (38%)
		leucine-rich repeat	397..440	CDD:275380	9/44 (20%)
		leucine-rich repeat	418..431	CDD:275378	3/12 (25%)
		leucine-rich repeat	441..492	CDD:275380	19/138 (14%)
		leucine-rich repeat	493..521	CDD:275380	6/35 (17%)
		leucine-rich repeat	522..545	CDD:275380	8/27 (30%)
		leucine-rich repeat	546..569	CDD:275380	7/22 (32%)
		leucine-rich repeat	570..591	CDD:275380	3/20 (15%)