DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and lrrk2

DIOPT Version :10

Sequence 1:NP_524081.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:XP_002932250.3 Gene:lrrk2 / 100145062 XenbaseID:XB-GENE-5768572 Length:2514 Species:Xenopus tropicalis


Alignment Length:985 Identity:197/985 - (20%)
Similarity:329/985 - (33%) Gaps:318/985 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 DEIMAKSRLEAQSFAHLVRLQQLSIQYCKLGRLGRQVLDGLEQLRNLTLRTHNILWPALNFEI-E 192
            :||..||.   .|..||...::..|.|..:...|..        .:|.:|..|.:.   |.|| :
 Frog   868 EEIHEKSE---DSLPHLDVFEEAGISYSDVDSEGSG--------GSLRIRKSNSIG---NLEIHK 918

  Fly   193 ADAFSVTRRLERLDLSSNNIWSLPDNI-----FCTLSELSA-LNMSENRLQDVNELGFRDRSKEP 251
            .|...:.||    ..:|...|:....:     |..:....| |:::..|...::.|..:|..|  
 Frog   919 LDHVKLWRR----HCNSLGTWADEPTVHRKKDFPQMDYPGAKLSLNIKRADSLSSLAEKDHIK-- 977

  Fly   252 TNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVLPANGFGTLRRLRVLSVNNNGISMI 316
                                    ||||...|:.:.:.:|...:....|.||..|.:.:|.:|..
 Frog   978 ------------------------SLDLSTNDLENINLIVKKGSLTNHLERLEKLELQHNSLSSF 1018

  Fly   317 ADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYLQNNSISVLNPQLFSNLDQLQALDL 381
            .......|::|..|:|..|...:.|..:.                          .:..|..||:
 Frog  1019 PKSLCEALRSLTYLDLRGNSFKSFPHYIL--------------------------EISSLVFLDV 1057

  Fly   382 SMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLYTLQILNLRHNQLENIAADTFAP 446
            |.|:|... :|.|:......|..||||:|:|......|.:....|:.|.:..|.:..|......|
 Frog  1058 SRNEIGPN-LDWNSTKMCPNLKQLNLSYNQLMSFPENIGNITQNLEELIMEGNNISEIHIPLCLP 1121

  Fly   447 MNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHPDAFRNCSALQDLNLNGNQLKTV 511
              .|||:.|:.|.:.:|....|.....|...|...| |:.:.|:..:..||::   |:.|::..:
 Frog  1122 --ELHTINLNKNSIHFLATDFLKDCVKLETFSATTN-LLSIAPNLPQKISAVK---LSHNKVTNI 1180

  Fly   512 PLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGNYLENITMHTFRDLPNLQILNLAR 576
            |..:..:.|||::||..|.|..:.       |.|....|  |..|.|..|.     ::.:|||::
 Frog  1181 PTEILQLSHLRSIDLSNNQIAHLP-------GPLEWTSL--NLREIILNHN-----HISVLNLSK 1231

  Fly   577 NRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMPSLLWLNISDNRLESFDYGHVPS----- 636
            :..         ..|.::.:.|..|::.:|      .|.:.:|    ..:.|||..:.|.     
 Frog  1232 DAC---------RWSRLEKLHLSYNKIKEI------PPEIGFL----ENITSFDISYNPDLRTFP 1277

  Fly   637 ------TLQWLDLHKNRLSSLSNRFGLDSELK---LQTLD-VSFNQLQRIGPSSIPNSIELLFLN 691
                  |..| ||..:.|.       ||.:||   .:..| :.|.| ||:..:...|.:::|.:.
 Frog  1278 DEMGKLTKIW-DLPLDGLC-------LDIDLKHIGCKAKDLIRFLQ-QRLKKAVPYNRMKVLIVG 1333

  Fly   692 DNLITTVDPDTFMHKTNLT-------RVDLYANQITT-LDIKSLRI-----------LPVWEHRA 737
                     :|...||.|.       |::..|.:.|. :|:|...|           |.||:...
 Frog  1334 ---------NTGSGKTTLVQQLMKCRRLEHGAEKATVGIDVKDWPILIRGKIKKEITLNVWDFAG 1389

  Fly   738 LPEFYIGGNPFTCDCNIDWLQKINHITSRQYPRIMDLETIYCKLLNNRERAYIPLIEAEPKHFLC 802
            ..|||.....|...      |.:..:.......:.:::.|...|.|.:.||     .:.|...:.
 Frog  1390 QEEFYCSHPHFMTP------QALYLVVYDLSKGVSEVDAIKPWLFNIKARA-----SSSPVILVG 1443

  Fly   803 TYKTHCFAVCHCCEFDACD--CEMTCPTNC---TC----------FHDQTWS-----------TN 841
            |:            .|..|  |:..|.:..   .|          :|....|           |.
 Frog  1444 TH------------LDVSDEKCQKACISKIKQELCNQRGLPSIREYHFVNASEESDLLAKLRKTI 1496

  Fly   842 IVECSGAAYSEMP---RRVPMDTSELYIDGNNFVELAGHSFLGRKNLAVLYANNSNVAHIYNTTF 903
            |.||......|.|   :.:|          ::::||.......|||:.:.:   ..::|      
 Frog  1497 IRECLNFKIREQPVLGQLIP----------DSYLELEKKILNERKNVPLEF---PVISH------ 1542

  Fly   904 SGLKRLL------ILHLEDNHIISLEGNEFHNLENLRELYLQSNKIASIANGSFQMLRKLEVLRL 962
               :|:|      .|||::|.:.       |.:..|.|                           
 Frog  1543 ---ERMLEIVEESQLHLDENELT-------HAVHFLNE--------------------------- 1570

  Fly   963 DGNRLMHFEVWQLSANPYLVEISLADNQWSCE----------------------CGYLARF---- 1001
             ...|:|||...|.    |.::...|.||.|:                      |..:.||    
 Frog  1571 -SGVLLHFEDPALQ----LRDLYFVDPQWLCKIIAQILTVRADGCQKYPKGIIHCNDVERFLEKK 1630

  Fly  1002 ----RNYLGQ 1007
                :||:.|
 Frog  1631 KKFPKNYMSQ 1640

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_524081.1 PPP1R42 <135..>242 CDD:455733 22/113 (19%)
leucine-rich repeat 148..171 CDD:275380 3/22 (14%)
leucine-rich repeat 172..201 CDD:275380 7/29 (24%)
LRR_8 200..>246 CDD:404697 9/51 (18%)
leucine-rich repeat 202..278 CDD:275380 10/81 (12%)
leucine-rich repeat 229..249 CDD:275380 4/19 (21%)
leucine-rich repeat 279..302 CDD:275380 4/22 (18%)
LRR 299..654 CDD:443914 82/365 (22%)
leucine-rich repeat 303..326 CDD:275380 5/22 (23%)
leucine-rich repeat 327..350 CDD:275380 5/22 (23%)
leucine-rich repeat 352..375 CDD:275380 0/22 (0%)
leucine-rich repeat 376..401 CDD:275380 8/24 (33%)
leucine-rich repeat 402..425 CDD:275380 8/22 (36%)
leucine-rich repeat 426..449 CDD:275380 5/22 (23%)
leucine-rich repeat 450..473 CDD:275380 7/22 (32%)
leucine-rich repeat 474..497 CDD:275380 5/22 (23%)
leucine-rich repeat 498..518 CDD:275380 3/19 (16%)
leucine-rich repeat 521..544 CDD:275380 6/22 (27%)
leucine-rich repeat 545..566 CDD:275380 6/20 (30%)
leucine-rich repeat 569..592 CDD:275380 3/22 (14%)
leucine-rich repeat 593..615 CDD:275380 3/21 (14%)
leucine-rich repeat 616..637 CDD:275380 5/31 (16%)
leucine-rich repeat 638..662 CDD:275380 6/23 (26%)
LRR_8 662..719 CDD:404697 14/67 (21%)
leucine-rich repeat 663..684 CDD:275380 5/21 (24%)
leucine-rich repeat 685..708 CDD:275380 3/22 (14%)
leucine-rich repeat 709..728 CDD:275380 6/26 (23%)
LRR <863..>990 CDD:443914 22/132 (17%)
leucine-rich repeat 885..908 CDD:275380 1/22 (5%)
leucine-rich repeat 909..932 CDD:275380 6/28 (21%)
leucine-rich repeat 933..956 CDD:275380 2/22 (9%)
TIR 1114..1247 CDD:214587
lrrk2XP_002932250.3 ANKYR <697..798 CDD:440430
LRR 956..>1231 CDD:443914 78/347 (22%)
leucine-rich repeat 977..1004 CDD:275380 8/52 (15%)
leucine-rich repeat 1005..1028 CDD:275380 5/22 (23%)
leucine-rich repeat 1029..1051 CDD:275380 5/47 (11%)
leucine-rich repeat 1052..1076 CDD:275380 8/24 (33%)
leucine-rich repeat 1077..1100 CDD:275380 8/22 (36%)
leucine-rich repeat 1101..1122 CDD:275380 5/22 (23%)
leucine-rich repeat 1123..1146 CDD:275380 7/22 (32%)
leucine-rich repeat 1147..1189 CDD:275380 10/45 (22%)
leucine-rich repeat 1190..1213 CDD:275380 9/31 (29%)
leucine-rich repeat 1214..1238 CDD:275380 6/37 (16%)
P-loop containing Nucleoside Triphosphate Hydrolases 1326..1499 CDD:476819 35/204 (17%)
COR 1516..1732 CDD:406489 32/186 (17%)
STKc_LRRK2 1876..2127 CDD:270970
Blue background indicates that the domain is not in the aligned region.

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