DRSC/TRiP Functional Genomics Resources

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Protein Alignment Toll-6 and lrrn1-like

DIOPT Version :9

Sequence 1:NP_001246765.1 Gene:Toll-6 / 39663 FlyBaseID:FBgn0036494 Length:1514 Species:Drosophila melanogaster
Sequence 2:NP_001106456.1 Gene:lrrn1-like / 100127637 XenbaseID:XB-GENE-492890 Length:738 Species:Xenopus tropicalis


Alignment Length:705 Identity:153/705 - (21%)
Similarity:246/705 - (34%) Gaps:238/705 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 MQPSTPARTLRPLTAGAGGDPSLYDAPDDC------H--FMPAAGLDQPEIALTCNLR------T 102
            |:.:.|||:.|.       .|.|:  .:.|      |  |....|:..|:  ..|..|      :
 Frog     1 MRHTNPARSQRM-------KPPLW--METCLFVIVLHSVFFSTLGVCPPQ--CVCETRPWFTPQS 54

  Fly   103 VNSEFDTTNFSVIPAEHTIALHILCNDEIMAKSRLEAQSFAHL-----VRLQQLSIQYCKLGRLG 162
            |..|..|.:               |||.::          .|:     ..:|.|.:|..|:..|.
 Frog    55 VYHEAKTVD---------------CNDLLL----------THIPENLSTDIQVLLLQSNKISHLT 94

  Fly   163 RQVLDGLEQLRNLTLRTHNILWPALNFEIEADAFSVTRRLERLDLSSNNIWSLPDNIFCTLSELS 227
            .:    |::|.|||                           .||||.|:..|:.|.....||:|.
 Frog    95 WE----LQELSNLT---------------------------ELDLSQNHFQSIDDLGVSNLSQLI 128

  Fly   228 ALNMSENRLQDVNELGFRDRSKEPTNGSTESTSTTESAKKSSSSSTSCSLDLEYLDVSHNDFVVL 292
            .|.:.||:|:::.:...:|.      ||                       ||.|.::||....:
 Frog   129 TLYLEENQLRELPDYSLKDL------GS-----------------------LEELYINHNQISYI 164

  Fly   293 PANGFGTLRRLRVLSVNNNGISMIADKALSGLKNLQILNLSSNKIVALPTELFAEQAKIIQEVYL 357
            ....|..|.||..|.:|.|.:.:|..:....|.||:||.:..|.:.||.:               
 Frog   165 GPRAFSGLGRLLRLHLNANRLEIIDPRWFEDLPNLEILMVGENPVTALQS--------------- 214

  Fly   358 QNNSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSD 422
                   ||   |..|.:|.:|.|:..::..  |.:|.|.||..|..|:...|:||::..|...:
 Frog   215 -------LN---FQPLGRLHSLVLAGMELEH--IPENAFQGLDYLESLSFFDNRLTEVPKEALKN 267

  Fly   423 LYTLQILNLRHNQLENIAADTFAPMNNLHTLLL-SHNKLKYLDAYALNGLYVLSLLSLDNNALIG 486
            |..|:.|:|..|.:..|....|..|.:|..|.| |..:|:.::|.|...|..|..|.:.||..:.
 Frog   268 LKLLKFLDLNKNPIPEIRGGDFTGMEHLEELSLNSMEELERVEAEAFQDLPELIKLEMCNNPRLS 332

  Fly   487 -VHPDAF-RNCSALQDLNLNGNQLKTVPLALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLR 549
             :.|:|| .|..||:.|.||.|:|..|||.:                       |:.|..|..:.
 Frog   333 YLDPEAFSSNLGALKTLLLNNNRLAMVPLKI-----------------------FQALPGLLEIS 374

  Fly   550 LIGNYLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDINGLFSNMP 614
            |..|.:.....:.::.|..|:::..             :.|..|....:.|:       ||..:.
 Frog   375 LYSNPIRCDCQNCWKGLSKLRLIEA-------------QATLCINPPLVSGH-------LFQEIQ 419

  Fly   615 SLLWLN----ISDNRLESFDY---------------GHVPSTLQWLDLHKNRLSSLSNRFGLDSE 660
            ...|||    :.|..|....:               ||....:.|:..|..|::..:.|..:::.
 Frog   420 GQAWLNRCPPLIDTHLIPPQFQIARHQPVKLSCQASGHPKPEIYWMTPHGERVTGTNGRVKINAG 484

  Fly   661 LKLQTLD-------------------------VSFNQLQRIGPSSIPNSIELLFL 690
            ..|:..|                         ||.|:.|.      |.::.||.:
 Frog   485 GSLEITDAVEEDSGSYTCQMWNSDGTDSKSVFVSINRTQE------PEAMSLLMV 533

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Toll-6NP_001246765.1 leucine-rich repeat 148..171 CDD:275380 6/22 (27%)
LRR_8 171..236 CDD:290566 17/64 (27%)
leucine-rich repeat 172..201 CDD:275380 4/28 (14%)
leucine-rich repeat 202..278 CDD:275380 17/75 (23%)
leucine-rich repeat 229..249 CDD:275380 5/19 (26%)
LRR_RI 278..468 CDD:238064 53/190 (28%)
leucine-rich repeat 279..302 CDD:275380 7/22 (32%)
LRR_8 301..386 CDD:290566 21/84 (25%)
leucine-rich repeat 303..326 CDD:275380 6/22 (27%)
leucine-rich repeat 327..350 CDD:275380 6/22 (27%)
LRR 350..729 CDD:227223 84/388 (22%)
leucine-rich repeat 352..375 CDD:275380 4/22 (18%)
leucine-rich repeat 376..401 CDD:275380 8/24 (33%)
LRR_RI <401..626 CDD:238064 56/231 (24%)
leucine-rich repeat 402..425 CDD:275380 7/22 (32%)
leucine-rich repeat 426..449 CDD:275380 7/22 (32%)
leucine-rich repeat 450..473 CDD:275380 8/23 (35%)
leucine-rich repeat 474..497 CDD:275380 8/24 (33%)
leucine-rich repeat 498..518 CDD:275380 9/19 (47%)
leucine-rich repeat 521..544 CDD:275380 2/22 (9%)
leucine-rich repeat 545..566 CDD:275380 3/20 (15%)
leucine-rich repeat 569..592 CDD:275380 2/22 (9%)
leucine-rich repeat 593..615 CDD:275380 4/21 (19%)
leucine-rich repeat 616..637 CDD:275380 7/39 (18%)
leucine-rich repeat 638..662 CDD:275380 4/23 (17%)
leucine-rich repeat 663..684 CDD:275380 7/45 (16%)
leucine-rich repeat 685..708 CDD:275380 2/6 (33%)
leucine-rich repeat 709..728 CDD:275380
LRR_8 883..943 CDD:290566
leucine-rich repeat 885..908 CDD:275380
leucine-rich repeat 909..932 CDD:275380
LRR_8 932..990 CDD:290566
leucine-rich repeat 933..956 CDD:275380
TIR 1114..1247 CDD:214587
lrrn1-likeNP_001106456.1 NEL <52..>262 CDD:330839 72/321 (22%)
leucine-rich repeat 60..79 CDD:275380 5/43 (12%)
leucine-rich repeat 80..102 CDD:275380 7/25 (28%)
LRR_8 101..161 CDD:316378 25/115 (22%)
leucine-rich repeat 103..126 CDD:275380 10/49 (20%)
leucine-rich repeat 127..150 CDD:275380 6/28 (21%)
leucine-rich repeat 151..174 CDD:275380 7/22 (32%)
leucine-rich repeat 175..198 CDD:275380 6/22 (27%)
leucine-rich repeat 199..222 CDD:275380 10/47 (21%)
leucine-rich repeat 223..246 CDD:275380 8/24 (33%)
leucine-rich repeat 247..294 CDD:275380 14/46 (30%)
LRR_8 294..356 CDD:316378 22/61 (36%)
leucine-rich repeat 295..319 CDD:275380 8/23 (35%)
leucine-rich repeat 320..345 CDD:275380 8/24 (33%)
leucine-rich repeat 346..367 CDD:275380 10/43 (23%)
PCC 351..>412 CDD:188093 16/96 (17%)
leucine-rich repeat 370..382 CDD:275378 3/11 (27%)
Ig 448..515 CDD:319273 8/66 (12%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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