DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Toll-6 and lrrtm4l1

DIOPT Version :9

Sequence 1:	NP_001246765.1	Gene:	Toll-6 / 39663	FlyBaseID:	FBgn0036494	Length:	1514	Species:	Drosophila melanogaster
Sequence 2:	NP_001373591.1	Gene:	lrrtm4l1 / 100000724	ZFINID:	ZDB-GENE-080327-15	Length:	571	Species:	Danio rerio

Alignment Length:	627	Identity:	143/627 - (22%)
Similarity:	225/627 - (35%)	Gaps:	186/627 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 SMIADKALSGLKNLQ---ILNLSS------------NKIVALPTELFAEQAKII----QEVYLQN 359
            |:..|..|:||..||   :|..||            .|||...:..|.:..:.|    |.:.|:.
Zfish     3 SLACDMRLAGLLLLQASSLLLFSSGERMCPYSCHCEGKIVHCESSAFQDVPENISVSCQGLSLRY 67

  Fly   360 NSISVLNPQLFSNLDQLQALDLSMNQITSTWIDKNTFVGLIRLVLLNLSHNKLTKLEPEIFSDLY 424
            |.:..:.|..|::|:||..|.|..|||  .::|...|.|:.||..|.||.|::
Zfish    68 NDLHTMLPYQFAHLNQLLWLYLDHNQI--MFVDSRAFQGVRRLKELILSSNRI------------ 118

  Fly   425 TLQILNLRHNQLENIAADTFAPMNNLHTLLLSHNKLKYLDAYALNGLYVLSLLSLDNNALIGVHP 489
                     :||.|:   ||..:.||.:|.||:|||:.|                        .|
Zfish   119 ---------SQLHNV---TFHGVPNLRSLDLSYNKLQEL------------------------QP 147

  Fly   490 DAFRNCSALQDLNLNGNQLKTVPL-ALRNMRHLRTVDLGENMITVMEDSAFKGLGNLYGLRLIGN 553
            ..|.....||:|:|..|.|..:|: |....|.|..:|||.|.:.|:..:||.||..|..|.|..|
Zfish   148 GQFYGLRKLQNLHLRSNGLTAIPVRAFLECRSLEFLDLGYNRLRVLTRTAFLGLSRLMELHLEHN 212

  Fly   554 YLENITMHTFRDLPNLQILNLARNRIAVVEPGAFEMTSSIQAVRLDGNELNDING-LFSNMPSLL 617
            ....|....|..|.||:.|.|..|||..|..|......::|.:.:.|||:..::. :|..:|:|.
Zfish   213 QFSRINFFLFPRLANLRALYLQWNRIRAVNQGLPWSWYTLQRLDISGNEIQVLDPVVFQCLPNLQ 277

  Fly   618 WLNISDNRLES---------------------FDYG-----------------------HVPSTL 638
            .||:..|:|.:                     :|.|                       ..|..|
Zfish   278 VLNLESNKLANVSQEVVAAWISLTTISLAGNMWDCGPGICPLVVWLKNFRGTKDTNIICSSPKHL 342

  Fly   639 QW---LDLHKNRLSSLSNRFGLDSELKLQTLDVSFN-QLQRIGPSSIPNSIELLFLNDNLITTVD 699
            |.   ::..||.:..........|.|.|||.|.::: .|:...|:..|             ||..
Zfish   343 QGEKVIEASKNYIDCDDYEITAQSPLYLQTFDPNYDLALEPTEPTMAP-------------TTPP 394

  Fly   700 P---------------------DTFMHKTNLTRVDLYANQITTLDIKSLRILPVWEHRALPEFYI 743
            |                     .||..:||....|.:....::.|...:..:|..::.:..:..:
Zfish   395 PPLPSPASEAPFPPPQPRPPHRPTFPSRTNTDPRDSHQRTPSSFDSSLVTPVPEQDNVSFHKVVM 459

  Fly   744 GGNPFTCDCNIDWLQKINHITSRQYP---RIMDLETIYCK--------------LLNNRERAYIP 791
            ||  .....::..:..:.:::.::||   |::...::..|              .|.....:|.|
Zfish   460 GG--VALFFSVSLVLSVIYVSCKRYPGATRLLQQSSVGRKRRKKSQEPEQNLSSQLQEYYMSYNP 522

  Fly   792 LIEAEPKHFL------CTYKTHCFAVCHCCEFDACDCEMTCP 827
            ....|....|      ||        |.......|:.|.:||
Zfish   523 AATPEALEVLGNGTGTCT--------CTISGSRECENEYSCP 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Toll-6	NP_001246765.1	leucine-rich repeat	148..171	CDD:275380
		LRR_8	171..236	CDD:290566
		leucine-rich repeat	172..201	CDD:275380
		leucine-rich repeat	202..278	CDD:275380
		leucine-rich repeat	229..249	CDD:275380
		LRR_RI	278..468	CDD:238064	51/172 (30%)
		leucine-rich repeat	279..302	CDD:275380
		LRR_8	301..386	CDD:290566	26/90 (29%)
		leucine-rich repeat	303..326	CDD:275380	5/11 (45%)
		leucine-rich repeat	327..350	CDD:275380	9/37 (24%)
		LRR	350..729	CDD:227223	110/453 (24%)
		leucine-rich repeat	352..375	CDD:275380	7/26 (27%)
		leucine-rich repeat	376..401	CDD:275380	9/24 (38%)
		LRR_RI	<401..626	CDD:238064	67/226 (30%)
		leucine-rich repeat	402..425	CDD:275380	5/22 (23%)
		leucine-rich repeat	426..449	CDD:275380	5/22 (23%)
		leucine-rich repeat	450..473	CDD:275380	8/22 (36%)
		leucine-rich repeat	474..497	CDD:275380	2/22 (9%)
		leucine-rich repeat	498..518	CDD:275380	8/20 (40%)
		leucine-rich repeat	521..544	CDD:275380	10/22 (45%)
		leucine-rich repeat	545..566	CDD:275380	6/20 (30%)
		leucine-rich repeat	569..592	CDD:275380	8/22 (36%)
		leucine-rich repeat	593..615	CDD:275380	5/22 (23%)
		leucine-rich repeat	616..637	CDD:275380	8/64 (13%)
		leucine-rich repeat	638..662	CDD:275380	5/26 (19%)
		leucine-rich repeat	663..684	CDD:275380	7/21 (33%)
		leucine-rich repeat	685..708	CDD:275380	5/43 (12%)
		leucine-rich repeat	709..728	CDD:275380	2/18 (11%)
		LRR_8	883..943	CDD:290566
		leucine-rich repeat	885..908	CDD:275380
		leucine-rich repeat	909..932	CDD:275380
		LRR_8	932..990	CDD:290566
		leucine-rich repeat	933..956	CDD:275380
		TIR	1114..1247	CDD:214587
lrrtm4l1	NP_001373591.1	leucine-rich repeat	60..83	CDD:275380	6/22 (27%)
		LRR_8	63..118	CDD:404697	21/56 (38%)
		leucine-rich repeat	84..107	CDD:275380	9/24 (38%)
		LRR_8	106..166	CDD:404697	27/107 (25%)
		leucine-rich repeat	108..131	CDD:275380	10/46 (22%)
		leucine-rich repeat	132..155	CDD:275380	10/46 (22%)
		PPP1R42	153..308	CDD:411060	46/154 (30%)
		leucine-rich repeat	156..179	CDD:275380	8/22 (36%)
		leucine-rich repeat	180..203	CDD:275380	10/22 (45%)
		leucine-rich repeat	204..227	CDD:275380	7/22 (32%)
		leucine-rich repeat	228..251	CDD:275380	8/22 (36%)
		leucine-rich repeat	252..275	CDD:275380	5/22 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910