DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG7255 and HIP1

DIOPT Version :9

Sequence 1:	NP_001034016.1	Gene:	CG7255 / 39662	FlyBaseID:	FBgn0036493	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	NP_011707.1	Gene:	HIP1 / 853104	SGDID:	S000003423	Length:	603	Species:	Saccharomyces cerevisiae

Alignment Length:	455	Identity:	107/455 - (23%)
Similarity:	180/455 - (39%)	Gaps:	84/455 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 RKNLQADGSE-GETKLNRVLGLWDLTALGVGSTLGAGVYVLAGQIAKDQAGP-SVMISFAIAALA 76
            |:|...:..: ..|.|::.|.:..|..|.||..:|.|:||..| .|....|| |::|.:.|.:..
Yeast    71 RRNEDTEQEDINNTNLSKDLSVRHLLTLAVGGAIGTGLYVNTG-AALSTGGPASLVIDWVIISTC 134

  Fly    77 SLLAGVCYAEFGARVPKAGSAYVYSYVCIGEFVAFVIG------WNLILEYVIGTASVCRGISLY 135
            .........|..|..|..|...|||...|....||.:.      |.::|...:..||:.  |..:
Yeast   135 LFTVINSLGELSAAFPVVGGFNVYSMRFIEPSFAFAVNLNYLAQWLVLLPLELVAASIT--IKYW 197

  Fly   136 LDSLLNDT-LKYTFAEVAPMNVSFLGSYFDFLAFGLVVVFGVALAFGVETSTMAN--NFVTCLNI 197
            .|.:.:|. :...:|.:|      |.:..|..:||             ||..:.:  ..::.:..
Yeast   198 NDKINSDAWVAIFYATIA------LANMLDVKSFG-------------ETEFVLSMIKILSIIGF 243

  Fly   198 FILGFVIIAGA------LKADYSNWTVDPSTVSANSTIGSGGFFPFGFEGTLRGAATCFFGFVGF 256
            .|||.|:..|.      :...|  |. ||.....:|   ||    ..|:|......|..|.:.|.
Yeast   244 TILGIVLSCGGGPHGGYIGGKY--WH-DPGAFVGHS---SG----TQFKGLCSVFVTAAFSYSGI 298

  Fly   257 DCIATTGEEVRNPRKNIPKSILLSLLIIFLCYFGVSTVLTLMLP----------YYIQDVNAPLP 311
            :..|.:..|.:|||:.|||:...:..:|...|..:.|::..::|          ..:...::||.
Yeast   299 EMTAVSAAESKNPRETIPKAAKRTFWLITASYVTILTLIGCLVPSNDPRLLNGSSSVDAASSPLV 363

  Fly   312 YAFE---YVGWPVAMWIVTVGGLVGLLASLFGALFPLPRVMYSMAQDGLLFKFLGKVSPRFRVPV 373
            .|.|   ..|.|..|..:.   |:.:::....|::...|.|.:||..|.|.|||.:|..|.| |:
Yeast   364 IAIENGGIKGLPSLMNAII---LIAVVSVANSAVYACSRCMVAMAHIGNLPKFLNRVDKRGR-PM 424

  Fly   374 TGSIVAALFTAAIAGLFD-----------LSQLVSLLSIGTLLAYSVVAISIMLLRYMDYCEVDE 427
            ...::...|     ||..           .:.|.:|..:.|:..:  :||::..:|:....:|.|
Yeast   425 NAILLTLFF-----GLLSFVAASDKQAEVFTWLSALSGLSTIFCW--MAINLSHIRFRQAMKVQE 482

Fly 428 427
Yeast 483 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG7255	NP_001034016.1	2A0303	9..581	CDD:273330	107/455 (24%)
CG7255	NP_001034016.1	AA_permease_C	537..580	CDD:290617
HIP1	NP_011707.1	2A0310	88..567	CDD:273334	103/438 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	90	1.000	Inparanoid score	I1545
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46729
orthoMCL	1	0.900	-	-		OOG6_100168
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X81
TreeFam	0	0.000	Not matched by this tool.
	6	5.760